MRI-compatible electromagnetic servomotor for image-guided medical robotics

Combining the unmatched soft-tissue imaging capabilities of magnetic resonance imaging (MRI) with high precision robotics has the potential to improve the accuracy, precision, and safety of a wide range of image-guided medical procedures. However, the goal of highly functional MRIcompatible robotic systems has not yet been realized because conventional electromagnetic servomotors used by medical robots can become dangerous projectiles near the strong magnetic field of an MRI scanner. Here we report a novel electromagnetic servomotor design that is constructed from non-magnetic components and can operate within the patient area of clinical scanners. We show that this design enables high-torque and precisely controlled rotary actuation during imaging. Using this servomotor design, an MRI-compatible robot was constructed and tested. The robot demonstrated that the linear forces required to manipulate large diameter surgical instruments in tissues could be achieved during simultaneous imaging with MRI. This work presents the first fully functional electromagnetic servomotor that can be safely operated (while imaging) in the patient area of a 3 Tesla clinical MRI scanner.

[1]  D. Louis Collins,et al.  Brain shift in neuronavigation of brain tumors: A review , 2017, Medical Image Anal..

[2]  P. Pillay,et al.  Application characteristics of permanent magnet synchronous and brushless DC motors for servo drives , 1991 .

[3]  Gabor Fichtinger,et al.  MRI Compatibility of Robot Actuation Techniques - A Comparative Study , 2008, MICCAI.

[4]  Kemal Tuncali,et al.  Development and Preliminary Evaluation of a Motorized Needle Guide Template for MRI-Guided Targeted Prostate Biopsy , 2013, IEEE Transactions on Biomedical Engineering.

[5]  H. Ahmed,et al.  Prostate Cancer Risk Inflation as a Consequence of Image-targeted Biopsy of the Prostate: A Computer Simulation Study , 2014, European urology.

[6]  T. Schwartz,et al.  Intraoperative MRI versus 5-ALA in high-grade glioma resection: a network meta-analysis. , 2020, Journal of neurosurgery.

[7]  Haiying Liu,et al.  Investigation of intraoperative brain deformation using a 1.5-T interventional MR system: preliminary results , 1998, IEEE Transactions on Medical Imaging.

[8]  Stefano Stramigioli,et al.  Stormram 4: An MR Safe Robotic System for Breast Biopsy , 2018, Annals of Biomedical Engineering.

[9]  R. Kikinis,et al.  Development and implementation of intraoperative magnetic resonance imaging and its neurosurgical applications. , 1997, Neurosurgery.

[10]  Mitchel S. Berger,et al.  Maximizing safe resection of low- and high-grade glioma , 2016, Journal of Neuro-Oncology.

[11]  Constance D Lehman,et al.  Clinical experience with MRI-guided vacuum-assisted breast biopsy. , 2005, AJR. American journal of roentgenology.

[12]  S. DiMaio,et al.  Transperineal prostate biopsy under magnetic resonance image guidance: A needle placement accuracy study , 2007, Journal of magnetic resonance imaging : JMRI.

[13]  K. Phan,et al.  Accuracy of MRI-based vs. CT-based patient-specific instrumentation in total knee arthroplasty: A meta-analysis. , 2017, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.

[14]  Steven S Raman,et al.  Use of MR imaging to determine preservation of the neurovascular bundles at robotic-assisted laparoscopic prostatectomy. , 2012, Radiology.

[15]  R. Gross,et al.  MRI-guided stereotactic laser corpus callosotomy for epilepsy: distinct methods and outcomes. , 2021, Journal of neurosurgery.

[16]  R. Kikinis,et al.  Superconducting open-configuration MR imaging system for image-guided therapy. , 1995, Radiology.

[17]  B. Park,et al.  Influence of magnetic resonance imaging in the decision to preserve or resect neurovascular bundles at robotic assisted laparoscopic radical prostatectomy. , 2014, The Journal of urology.

[18]  Z L Gokaslan,et al.  A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. , 2001, Journal of neurosurgery.

[19]  C. Stippich,et al.  Diagnostic benefits of presurgical fMRI in patients with brain tumours in the primary sensorimotor cortex , 2011, European Radiology.

[20]  Peter Kellman,et al.  Image reconstruction in SNR units: A general method for SNR measurement † , 2005, Magnetic resonance in medicine.

[21]  Robert G. Moore,et al.  Initial clinical experience , 1997 .

[22]  N. Hata,et al.  Serial Intraoperative Magnetic Resonance Imaging of Brain Shift , 2001, Neurosurgery.

[23]  Nobuhiko Hata,et al.  Surgical assist robot for the active navigation in the intraoperative MRI: hardware design issues , 2000, Proceedings. 2000 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2000) (Cat. No.00CH37113).

[24]  S. Misra,et al.  Evaluation of a robotic technique for transrectal MRI-guided prostate biopsies , 2011, European Radiology.

[25]  U-Xuan Tan,et al.  Design and Control of a 1-DOF MRI-Compatible Pneumatically Actuated Robot With Long Transmission Lines , 2011, IEEE/ASME Transactions on Mechatronics.

[26]  W. Kaiser,et al.  Robotic system for biopsy and therapy of breast lesions in a high-field whole-body magnetic resonance tomography unit. , 2000, Investigative radiology.

[27]  L. Liberman,et al.  MRI-guided 9-gauge vacuum-assisted breast biopsy: initial clinical experience. , 2005, AJR. American journal of roentgenology.

[28]  Gregory S. Fischer,et al.  An Integrated Robotic System for MRI-Guided Neuroablation: Preclinical Evaluation , 2020, IEEE Transactions on Biomedical Engineering.

[29]  P. Roemer,et al.  The NMR phased array , 1990, Magnetic resonance in medicine.

[30]  Kemal Tuncali,et al.  Evaluation of robot-assisted MRI-guided prostate biopsy: needle path analysis during clinical trials , 2018, Physics in medicine and biology.

[31]  F. Schmidt Meta-Analysis , 2008 .

[32]  Karl Herholz,et al.  Imaging in neurooncology , 2005, NeuroRX.

[33]  Paul S. Larson,et al.  Interventional MRI-guided deep brain stimulation in pediatric dystonia: first experience with the ClearPoint system. , 2014, Journal of neurosurgery. Pediatrics.

[34]  K. Hynynen,et al.  A Randomized Trial of Focused Ultrasound Thalamotomy for Essential Tremor. , 2016, The New England journal of medicine.

[35]  Alexandra J Golby,et al.  Origins of intraoperative MRI. , 2010, Magnetic resonance imaging clinics of North America.

[36]  F. Jolesz,et al.  Survival rates in patients with low‐grade glioma after intraoperative magnetic resonance image guidance , 2005, Cancer.

[37]  Carl-Fredrik Westin,et al.  Capturing intraoperative deformations: research experience at Brigham and Women's hospital , 2005, Medical Image Anal..

[38]  Hao Su,et al.  Robotic System for MRI-Guided Stereotactic Neurosurgery , 2015, IEEE Transactions on Biomedical Engineering.

[39]  A. de Laat,et al.  Network meta-analysis. , 2017, Journal of oral rehabilitation.

[40]  N. Sobol,et al.  Preliminary results , 2020, Asymptotic Analysis of Random Walks: Light-Tailed Distributions.

[41]  J. Hogg Magnetic resonance imaging. , 1994, Journal of the Royal Naval Medical Service.

[42]  Derek Seeber,et al.  Floating shield current suppression trap , 2004 .

[43]  H Iseki,et al.  Development of an MRI-compatible needle insertion manipulator for stereotactic neurosurgery. , 1995, Journal of image guided surgery.

[44]  D. Louw,et al.  A mobile high-field magnetic resonance system for neurosurgery. , 1999, Journal of neurosurgery.

[45]  G. Fichtinger,et al.  Development and Evaluation of an Actuated MRI-Compatible Robotic System for MRI-Guided Prostate Intervention , 2013, IEEE/ASME Transactions on Mechatronics.

[46]  L. Wald,et al.  A 64‐channel 3T array coil for accelerated brain MRI , 2013, Magnetic resonance in medicine.

[47]  R. C. Macridis A review , 1963 .

[48]  D. Margolis,et al.  MRI‐Targeted or Standard Biopsy for Prostate‐Cancer Diagnosis , 2018, The New England journal of medicine.