Biomimetic Accumulation of Methamphetamine and Its Metabolite Amphetamine by Diffusive Gradients in Thin Films to Estimate Their Bioavailability in Zebrafish

In this study, we evaluated the application of the diffusive gradient in the thin films (DGT) technique to predict the bioavailability of methamphetamine (METH) and its metabolite, amphetamine (AMP), in zebrafish (Danio rerio). We simultaneously exposed zebrafish and DGT devices to water spiked with different concentrations of METH. Subsequently, METH and its major metabolite, AMP, were quantified in DGTs and in zebrafish in vivo, the latter of which tended to bioaccumulate and biotransform METH to AMP. After a two-week duration of METH exposure, concentrations were up to 4.49 ± 0.17, 6.42 ± 0.06, and 132 ± 0.48 ng/g wet weight for METH and 4.25 ± 0.62, 8.46 ± 0.58, and 419 ± 45.0 ng/g wet weight for AMP in zebrafish when exposed to 0.01, 1.00, and 100.00 μg/L of METH solution, respectively. Although the in vivo bioaccumulation and biotransformation of METH in zebrafish are likely complex, we found a strong positive correlation (R2 = 0.97–1.00, p < 0.001) between the mass of METH uptake by the DGT and the...

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