Ethnic differences in pain, itch and thermal detection in response to topical capsaicin: African Americans display a notably limited hyperalgesia and neurogenic inflammation

Background  Topical application of capsaicin commonly produces burning, stinging and itching as well as hyperalgesia to heat stimuli via activation of transient receptor potential vanilloid subtype 1.

[1]  R. Fillingim,et al.  Ethnic differences in thermal pain responses. , 1999, Psychosomatic medicine.

[2]  H. Maibach,et al.  Sodium – lauryl – sulphate – induced cutaneous irritation , 1988, Contact dermatitis.

[3]  Hua Tang,et al.  Categorization of humans in biomedical research: genes, race and disease , 2002, Genome Biology.

[4]  K. Matsunaga,et al.  Immunoreactivity of VR1 on epidermal keratinocyte of human skin. , 2001, Biochemical and biophysical research communications.

[5]  H I Maibach,et al.  In vivo biophysical characterization of skin physiological differences in races. , 1991, Dermatologica.

[6]  Y. Y. Wang,et al.  In vitro and in vivo evaluations of topically applied capsaicin and nonivamide from hydrogels. , 2001, International journal of pharmaceutics.

[7]  H. Maibach,et al.  Racial differences in the in vivo percutaneous absorption of some organic compounds: a comparison between black, Caucasian and Asian subjects , 2004, Archives of Dermatological Research.

[8]  R. Fillingim,et al.  Race, ethnicity and pain , 2001, PAIN.

[9]  B. Zegarska,et al.  Clinical and experimental aspects of cutaneous neurogenic inflammation. , 2006, Pharmacological reports : PR.

[10]  M. Steinhoff,et al.  A TR(I)P to pruritus research: role of TRPV3 in inflammation and itch. , 2009, The Journal of investigative dermatology.

[11]  P. Wang,et al.  Increases in transient receptor potential vanilloid‐1 mRNA and protein in primary afferent neurons stimulated by protein kinase C and their possible role in neurogenic inflammation , 2009, Journal of neuroscience research.

[12]  B. Magnusson,et al.  In vitro percutaneous penetration of topically applied capsaicin in relation to in vivo sensation responses. , 2000, International journal of pharmaceutics.

[13]  R A Dionne,et al.  Genetic predictors for acute experimental cold and heat pain sensitivity in humans , 2006, Journal of Medical Genetics.

[14]  J. Lévêque,et al.  EEMCO Guidance for the Measurement of Skin Microcirculation , 2002, Skin Pharmacology and Physiology.

[15]  Makoto Tominaga,et al.  Heat-Evoked Activation of the Ion Channel, TRPV4 , 2002, The Journal of Neuroscience.

[16]  L. Wilkins Quantitative sensory testing , 1993, Neurology.

[17]  P. Blumberg,et al.  Vanilloid receptors: new insights enhance potential as a therapeutic target , 1996, Pain.

[18]  T. Fitzpatrick The validity and practicality of sun-reactive skin types I through VI. , 1988, Archives of dermatology.

[19]  M. Green,et al.  The epidermal nerve fibre network: characterization of nerve fibres in human skin by confocal microscopy and assessment of racial variations , 1997, The British journal of dermatology.

[20]  L. Pershing,et al.  Effects of vehicle on the uptake and elimination kinetics of capsaicinoids in human skin in vivo. , 2004, Toxicology and applied pharmacology.

[21]  J. Ochoa,et al.  Early and Late Effects of Prolonged Topical Capsaicin on Cutaneous Sensibility and Neurogenic Vasodilation in Humans , 1992 .

[22]  R. Fillingim,et al.  Ethnic differences in responses to multiple experimental pain stimuli , 2005, Pain.

[23]  Minoru Suzuki,et al.  Impact of the Gly573Ser substitution in TRPV3 on the development of allergic and pruritic dermatitis in mice. , 2009, The Journal of investigative dermatology.

[24]  L. Arendt-Nielsen,et al.  The impact of ethnic differences in response to capsaicin-induced trigeminal sensitization , 2005, Pain.

[25]  J. Ochoa,et al.  Early and late effects of prolonged topical capsaicin on cutaneous sensibility and neurogenic vasodilatation in humans , 1991, Pain.

[26]  R. Paus,et al.  TRP channels as novel players in the pathogenesis and therapy of itch. , 2007, Biochimica et biophysica acta.

[27]  M. Schumacher,et al.  Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures , 2004, Experimental dermatology.

[28]  M. Caterina,et al.  Warm Temperatures Activate TRPV4 in Mouse 308 Keratinocytes* , 2003, Journal of Biological Chemistry.

[29]  D. Clapham,et al.  Camphor Activates and Strongly Desensitizes the Transient Receptor Potential Vanilloid Subtype 1 Channel in a Vanilloid-Independent Mechanism , 2005, The Journal of Neuroscience.

[30]  A. Moqrich,et al.  Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin , 2005, Science.

[31]  M. Caterina,et al.  Overexpressed Transient Receptor Potential Vanilloid 3 Ion Channels in Skin Keratinocytes Modulate Pain Sensitivity via Prostaglandin E2 , 2008, The Journal of Neuroscience.

[32]  H. Maibach,et al.  Racial differences in sodium lauryl sulphate induced cutaneous irritation: black and white , 1988, Contact dermatitis.

[33]  Jeung-Hoon Lee,et al.  Expression of vanilloid receptor 1 in cultured fibroblast , 2006, Experimental dermatology.

[34]  A V Rawlings,et al.  Ethnic skin types: are there differences in skin structure and function? 1 , 2006, International journal of cosmetic science.

[35]  A. Akopian,et al.  Role of ionotropic cannabinoid receptors in peripheral antinociception and antihyperalgesia. , 2009, Trends in pharmacological sciences.

[36]  S. Koizumi,et al.  Functional vanilloid receptors in cultured normal human epidermal keratinocytes. , 2002, Biochemical and biophysical research communications.

[37]  David Sheffield,et al.  Race and Sex Differences in Cutaneous Pain Perception , 2000, Psychosomatic medicine.