Molecular Analysis of DNA Rearrangements in the Immune System
暂无分享,去创建一个
[1] S. E. Lee,et al. Restoration of X-ray and etoposide resistance, Ku-end binding activity and V(D) J recombination to the Chinese hamster sxi-3 mutant by a hamster Ku86 cDNA. , 1996, Mutation research.
[2] G. Chu,et al. Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants , 1996, Molecular and cellular biology.
[3] M. Wabl,et al. An immunoglobulin mutator that targets G.C base pairs. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[4] F. Alt,et al. The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination , 1995, Cell.
[5] Christina A. Cuomo,et al. Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps , 1995, Cell.
[6] P. Jeggo,et al. Nomenclature of human genes involved in ionizing radiation sensitivity. , 1995, Mutation research.
[7] R. Perlmutter,et al. Impaired expansion of mouse B cell progenitors lacking Btk. , 1995, Immunity.
[8] A. Lichtenstein,et al. Myeloma Ig heavy chain V region sequences reveal prior antigenic selection and marked somatic mutation but no intraclonal diversity. , 1995, Journal of immunology.
[9] S. Dong,et al. [Junctional sequences of T cell receptor V delta 2-D delta 3 or D delta 2-D delta 3 rearrangements in acute lymphoblastic leukemia]. , 1995, Zhonghua yi xue za zhi.
[10] F. Alt,et al. Defective B cell development and function in Btk-deficient mice. , 1995, Immunity.
[11] F. Alt,et al. Potential targets for autosomal SCID mutations. , 1995, Current opinion in immunology.
[12] Jian Yu,et al. Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis , 1995, Cell.
[13] Klaus Rajewsky,et al. Impairment of T-cell-dependent B-cell responses and B-l cell development in CD19-deficient mice , 1995, Nature.
[14] M. Zhu,et al. Immunoglobulin variable region hypermutation in hybrids derived from a pre-B- and a myeloma cell line. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[15] D. Ramsden,et al. Initiation of V(D)J recombination in a cell-free system , 1995, Cell.
[16] M. Lieber,et al. Strand specificity in the transcriptional targeting of recombination at immunoglobulin switch sequences. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[17] Andreas Radbruch,et al. How cytokines control immunoglobulin class switching. , 1995, Behring Institute Mitteilungen.
[18] K. Shokat,et al. Antigen-induced B-cell death and elimination during germinal-centre immune responses , 1995, Nature.
[19] M. Wabl,et al. Hypermutation in T cells questioned , 1995, Nature.
[20] H. P. Fell,et al. Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. , 1995, Immunity.
[21] J. Um,et al. Isolation of mammalian cell mutants that are X-ray sensitive, impaired in DNA double-strand break repair and defective for V(D)J recombination. , 1995, Mutation research.
[22] M. Zdzienicka,et al. Mammalian mutants defective in the response to ionizing radiation-induced DNA damage. , 1995, Mutation research.
[23] T. Stamato,et al. Regional localization of the XRCC4 human radiation repair gene. , 1995, Genomics.
[24] B. Gallois,et al. High-resolution structure of a DNA helix forming (C·G)*G base triplets , 1995, Nature.
[25] M. Zhu,et al. A well-differentiated B-cell line is permissive for somatic mutation of a transfected immunoglobulin heavy-chain gene. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[26] R. Jessberger,et al. Stimulation of Defective DNA Transfer Activity in Recombination Deficient SCID Cell Extracts by a 72-kDa Protein from Wild-type Thymocytes (*) , 1995, The Journal of Biological Chemistry.
[27] Andreas Radbruch,et al. Switch transcripts in immunoglobulin class switching. , 1995, Science.
[28] F. Alt,et al. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation , 1995, Cell.
[29] M. Lieber,et al. DNA Structural Elements Required for FEN-1 Binding (*) , 1995, The Journal of Biological Chemistry.
[30] H. K. Cheah,et al. Secondary deletional recombination of rearranged switch region in Ig isotype-switched B cells. A mechanism for isotype stabilization. , 1995, Journal of immunology.
[31] D. Chan,et al. Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line , 1995, Science.
[32] M. Oettinger,et al. DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect , 1995, Science.
[33] J. Karras,et al. Induction of the transcription factors NF-kappa B, AP-1 and NF-AT during B cell stimulation through the CD40 receptor. , 1995, International immunology.
[34] H. Band,et al. Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[35] David Baltimore,et al. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses , 1995, Cell.
[36] J. Weill,et al. Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process , 1995, Cell.
[37] C. Milstein,et al. Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[38] D. Rio,et al. A Drosophila protein homologous to the human p70 Ku autoimmune antigen interacts with the P transposable element inverted repeats. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[39] G. Kelsoe,et al. Locus-specific somatic hypermutation in germinal centre T cells , 1994, Nature.
[40] F. Alt,et al. CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[41] E. Wagner,et al. Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5 BSAP , 1994, Cell.
[42] Ian Krop,et al. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements , 1994, Cell.
[43] H. Weintraub,et al. The helix-loop-helix gene E2A is required for B cell formation , 1994, Cell.
[44] R. Kumar,et al. Extrachromosomal eukaryotic DNA substrates for switch recombination: analysis of isotype and cell specificity. , 1994, DNA and cell biology.
[45] R Fischer,et al. Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[46] L. Corcoran,et al. Oct-2 is required early in T cell-independent B cell activation for G1 progression and for proliferation. , 1994, Immunity.
[47] R J Armitage,et al. Humoral immune responses in CD40 ligand-deficient mice , 1994, The Journal of experimental medicine.
[48] R. Mage,et al. Rabbit IgH sequences in appendix germinal centers: VH diversification by gene conversion-like and hypermutation mechanisms. , 1994, Immunity.
[49] M. Lieber,et al. Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. , 1994, Science.
[50] S. McKnight,et al. An interleukin-4-induced transcription factor: IL-4 Stat. , 1994, Science.
[51] E. Selsing,et al. Analysis of sequence transfers resembling gene conversion in a mouse antibody transgene. , 1994, Science.
[52] F. Alt,et al. Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. , 1994, Science.
[53] J. Lebowitz,et al. Transcription induces the formation of a stable RNA.DNA hybrid in the immunoglobulin alpha switch region. , 1994, The Journal of biological chemistry.
[54] G. Chu,et al. Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[55] A. Radbruch,et al. Inhibition of class switch recombination in plasma cells. , 1994, Cellular Immunology.
[56] R. Flavell,et al. Mice deficient for the CD40 ligand. , 1994, Immunity.
[57] H. Ziegler-Heitbrock,et al. CD14 is expressed and functional in human B cells , 1994, European journal of immunology.
[58] Andrew H. Liu,et al. CD40 LIGAND MUTATIONS IN X-LINKED IMMUNODEFICIENCY WITH HYPER-IgM , 1994, Pediatrics.
[59] T. Mimori,et al. DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[60] J. Leszyk,et al. DNA-dependent ATPase from HeLa cells is related to human Ku autoantigen. , 1994, Biochemistry.
[61] N. Maizels,et al. A λ1 transgene under the control of a heavy chain promoter and enhancer does not undergo somatic hypermutation , 1994, European journal of immunology.
[62] J. Blanchard,et al. Chromosomal location and expression of the genes coding for Ku p70 and p80 in human cell lines and normal tissues. , 1994, Cytogenetics and cell genetics.
[63] G. Chu,et al. A DNA end-binding factor involved in double-strand break repair and V(D)J recombination , 1994, Molecular and cellular biology.
[64] R. Getts,et al. Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant. , 1994, The Journal of biological chemistry.
[65] F. Alt,et al. A class switch control region at the 3′ end of the immunoglobulin heavy chain locus , 1994, Cell.
[66] P. Hanawalt,et al. Repair and Transcription: Collision or collusion? , 1994, Current Biology.
[67] N. Yoshida,et al. The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. , 1994, Immunity.
[68] N. Maizels,et al. LR1 regulates c-myc transcription in B-cell lymphomas. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[69] T. Nguyen,et al. Regional assignment of a human DNA repair gene (XRCC5) to 2q35 by X-ray hybrid mapping. , 1994, Genomics.
[70] F. Alt,et al. Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation. , 1994, Genes & development.
[71] M. Wabl,et al. CAN WE OUTLIVE METHUSELAH , 1994 .
[72] C. Milstein,et al. Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region , 1994, Cell.
[73] P. C. Wensink,et al. Yolk protein factor 1 is a Drosophila homolog of Ku, the DNA-binding subunit of a DNA-dependent protein kinase from humans. , 1994, The Journal of biological chemistry.
[74] L. Notarangelo,et al. Defective Expression of CD40 Ligand on T Cells Causes “X‐Linked Immunodeficiency with Hyper‐IgM (HIGM1)” , 1994, Immunological reviews.
[75] R. Zinkernagel,et al. Impaired immune and acute-phase responses in interleukin-6-deficient mice , 1994, Nature.
[76] M. Busslinger,et al. The transcription factor BSAP (NF-HB) is essential for immunoglobulin germ-line epsilon transcription. , 1994, Journal of immunology.
[77] F. Alt,et al. A DNA repair defect in Chinese hamster ovary cells affects V(D)J recombination similarly to the murine scid mutation. , 1994, The Journal of biological chemistry.
[78] M. Lieber,et al. The characterization of a mammalian DNA structure‐specific endonuclease. , 1994, The EMBO journal.
[79] C. Schindler,et al. STF‐IL‐4: a novel IL‐4‐induced signal transducing factor. , 1994, The EMBO journal.
[80] S. Lewis,et al. P nucleotide insertions and the resolution of hairpin DNA structures in mammalian cells. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[81] Brian Charlesworth,et al. Genetic Recombination: Patterns in the genome , 1994, Current Biology.
[82] F. Alt,et al. S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process. , 1994, The EMBO journal.
[83] N. Maizels,et al. Regulation and targeting of recombination in extrachromosomal substrates carrying immunoglobulin switch region sequences. , 1994, Molecular and cellular biology.
[84] J. Sprent. T and B memory cells , 1994, Cell.
[85] M. Schlissel,et al. Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated. , 1993, Genes & development.
[86] K. Rajewsky,et al. Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. , 1993, The EMBO journal.
[87] G. Freeman,et al. Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice. , 1993, Science.
[88] C. Anderson,et al. DNA damage and the DNA-activated protein kinase. , 1993, Trends in biochemical sciences.
[89] G. Merkulov,et al. Switch recombination breakpoints occur at nonrandom positions in the S gamma tandem repeat. , 1993, Journal of Immunology.
[90] J. Mcwhir,et al. Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning , 1993, Nature Genetics.
[91] D. Weaver,et al. V(D)J recombination coding junction formation without DNA homology: processing of coding termini , 1993, Molecular and cellular biology.
[92] G. Kelsoe,et al. In situ studies of the primary immune response to (4-hydroxy-3- nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells , 1993, The Journal of experimental medicine.
[93] V. Stewart,et al. A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon. , 1993, The EMBO journal.
[94] P. Jeggo,et al. Subchromosomal localization of a gene (XRCC5) involved in double strand break repair to the region 2q34-36 , 1993, Somatic cell and molecular genetics.
[95] G. Litman,et al. Somatic variation precedes extensive diversification of germline sequences and combinatorial joining in the evolution of immunoglobulin heavy chain diversity , 1993, The Journal of experimental medicine.
[96] C. Benoist,et al. Mice lacking TdT: mature animals with an immature lymphocyte repertoire. , 1993, Science.
[97] T. Komori,et al. Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes. , 1993, Science.
[98] H. Bluethmann,et al. Targeted disruption of the MHC class II Aa gene in C57BL/6 mice. , 1993, International immunology.
[99] K P Lee,et al. Differential T cell costimulatory requirements in CD28-deficient mice. , 1993, Science.
[100] T. Mak,et al. Normal B lymphocyte development but impaired T cell maturation in CD45-Exon6 protein tyrosine phosphatase-deficient mice , 1993, Cell.
[101] R. Jessberger,et al. A mammalian protein complex that repairs double-strand breaks and deletions by recombination. , 1993, The Journal of biological chemistry.
[102] D. Baltimore,et al. Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[103] N. Maizels,et al. Purification and properties of LR1, an inducible DNA binding protein from mammalian B lymphocytes. , 1993, The Journal of biological chemistry.
[104] K. Rajewsky,et al. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting , 1993, Cell.
[105] M. Lieber,et al. Extent to which homology can constrain coding exon junctional diversity in V(D)J recombination , 1993, Nature.
[106] E. Winnacker,et al. A putative homologue of the human autoantigen Ku from Saccharomyces cerevisiae. , 1993, The Journal of biological chemistry.
[107] G. Kelsoe,et al. Sites of B-cell activation in vivo. , 1993, Current opinion in immunology.
[108] M. Lieber,et al. V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair , 1993, Molecular and cellular biology.
[109] M. Falzon,et al. EBP-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single- to double-strand transitions in DNA. , 1993, The Journal of biological chemistry.
[110] F. Alt,et al. Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[111] F. Alt,et al. Impairment of V(D)J recombination in double-strand break repair mutants. , 1993, Science.
[112] A. Griffith,et al. Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks. , 1993, The Journal of biological chemistry.
[113] J Erikson,et al. B lymphocytes may escape tolerance by revising their antigen receptors , 1993, The Journal of experimental medicine.
[114] T. Jacks,et al. Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival. , 1993, Genes & development.
[115] D. Nemazee,et al. Receptor editing in self-reactive bone marrow B cells , 1993, The Journal of experimental medicine.
[116] S. Camper,et al. Receptor editing: an approach by autoreactive B cells to escape tolerance , 1993, The Journal of experimental medicine.
[117] A. Bradley,et al. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. , 1993, Science.
[118] R. Zinkernagel,et al. Immune response in mice that lack the interferon-gamma receptor. , 1993, Science.
[119] Martin Bachmann,et al. Disruption of the murine IL-4 gene blocks Th2 cytokine responses , 1993, Nature.
[120] C. Milstein,et al. Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[121] I. Stamenkovic,et al. Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[122] G. Köhler,et al. Immunoglobulin D-deficient mice can mount normal immune responses to thymus-independent and -dependent antigens. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[123] S. Paillard,et al. Site‐specific proteolytic cleavage of Ku protein bound to DNA , 1993, Proteins.
[124] K. Rajewsky,et al. Shutdown of class switch recombination by deletion of a switch region control element , 1993, Science.
[125] J. Belmont,et al. CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome , 1993, Science.
[126] L. Notarangelo,et al. Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM , 1993, Nature.
[127] J. Bajorath,et al. The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome , 1993, Cell.
[128] S. Jackson,et al. The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen , 1993, Cell.
[129] M. Sporn,et al. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[130] K. Rajewsky,et al. Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells , 1993, The Journal of experimental medicine.
[131] H. Lu,et al. Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[132] C. Steinberg,et al. What limits affinity maturation of antibodies in Xenopus‐‐the rate of somatic mutation or the ability to select mutants? , 1992, The EMBO journal.
[133] N A Kolchanov,et al. Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis. , 1992, Biochimica et biophysica acta.
[134] G. Proetzel,et al. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease , 1992, Nature.
[135] G. Felsenfeld,et al. A nucleosome core is transferred out of the path of a transcribing polymerase , 1992, Cell.
[136] M. Lieber. The mechanism of V(D)J recombination: A balance of diversity, specificity, and stability , 1992, Cell.
[137] V. Roberts,et al. Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigen , 1992, The Journal of experimental medicine.
[138] G. Kelsoe,et al. In Situ Studies of the Primary Immune Response to ( 4-hydroxy-3-nitrophenyl ) acetyl . II . A Common Clonal Origin for Periarteriolar Lymphoid Sheath-associated Foci and Germinal Centers , 2003 .
[139] G. Merkulov,et al. Switch recombination breakpoints are strictly correlated with DNA recognition motifs for immunoglobulin S gamma 3 DNA-binding proteins , 1992, The Journal of experimental medicine.
[140] K. Marcu,et al. Properties of B cell stage specific and ubiquitous nuclear factors binding to immunoglobulin heavy chain gene switch regions. , 1992, International immunology.
[141] P. Jeggo,et al. Localization of a DNA repair gene (XRCC5) involved in double-strand-break rejoining to human chromosome 2. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[142] M. Wabl,et al. The murine IgG1/IgE class switch program , 1992, European journal of immunology.
[143] N. Maizels,et al. Transcriptional regulatory elements stimulate recombination in extrachromosomal substrates carrying immunoglobulin switch-region sequences. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[144] Reeves Wh,et al. Antibodies to the p70/p80 (Ku) antigens in systemic lupus erythematosus. , 1992 .
[145] J. Menetski,et al. V(D)J recombination in mouse thymocytes: Double-strand breaks near T cell receptor δ rearrangement signals , 1992, Cell.
[146] Susumu Tonegawa,et al. RAG-1-deficient mice have no mature B and T lymphocytes , 1992, Cell.
[147] V. Stewart,et al. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement , 1992, Cell.
[148] D. Jenssen,et al. Spectrum of spontaneously occurring mutations in the hprt gene of V79 Chinese hamster cells. , 1992, Journal of molecular biology.
[149] J. Stavnezer,et al. Regulation of transcription of immunoglobulin germ‐line gamma 1 RNA: analysis of the promoter/enhancer. , 1992, The EMBO journal.
[150] Klaus Rajewsky,et al. Intraclonal generation of antibody mutants in germinal centres , 1991, Nature.
[151] N. Maizels,et al. LR1, a lipopolysaccharide-responsive factor with binding sites in the immunoglobulin switch regions and heavy-chain enhancer. , 1991, Genes & development.
[152] U. Storb,et al. Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication. , 1991, The EMBO journal.
[153] G. Morahan,et al. Peripheral deletion of self-reactive B cells , 1991, Nature.
[154] M. Lieber. Site‐specific recombination in the immune system 1 , 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[155] K. Rajewsky,et al. Generation and analysis of interleukin-4 deficient mice. , 1991, Science.
[156] F. Strauss,et al. Analysis of the mechanism of interaction of simian Ku protein with DNA. , 1991, Nucleic acids research.
[157] C. Goodnow,et al. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens , 1991, Nature.
[158] MJ Grusby,et al. Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice , 1991, Science.
[159] M. Schilham,et al. Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4 , 1991, Nature.
[160] D. Gray,et al. Mice lacking MHC class II molecules , 1991, Cell.
[161] C. Snapper,et al. IgE class switching is critically dependent upon the nature of the B cell activator, in addition to the presence of IL-4. , 1991, Journal of immunology.
[162] I. Horak,et al. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting , 1991, Nature.
[163] C. Milstein,et al. Somatic hypermutation of immunoglobulin kappa may depend on sequences 3′ of C kappa and occurs on passenger transgenes. , 1991, The EMBO journal.
[164] H. Tesch,et al. DNA methylation profiles in the human genes for tumor necrosis factors alpha and beta in subpopulations of leukocytes and in leukemias. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[165] K. Rajewsky,et al. Most peripheral B cells in mice are ligand selected , 1991, The Journal of experimental medicine.
[166] V. F. Liu,et al. Strand breaks without DNA rearrangement in V (D)J recombination , 1991, Molecular and cellular biology.
[167] J. Gearhart,et al. Mutation in a reporter gene depends on proximity to and transcription of immunoglobulin variable transgenes. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[168] M. Neuberger,et al. The mouse IgH 3′‐enhancer , 1991, European journal of immunology.
[169] D. Schatz,et al. A link between double-strand break-related repair and V(D)J recombination: the scid mutation. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[170] C. Mackay,et al. Somatic generation of diversity in a mammalian primary lymphoid organ: The sheep ileal Peyer's patches , 1991, Cell.
[171] P. Jeggo,et al. Genetic analysis of ionising radiation sensitive mutants of cultured mammalian cell lines. , 1991, Mutation research.
[172] L. Eckhardt,et al. An enhancer at the 3' end of the mouse immunoglobulin heavy chain locus. , 1991, Nucleic acids research.
[173] A. Giaccia,et al. scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[174] R. Mage,et al. Preferrential rearrangement in normal rabbits of the 3′ VHa allotype gene that is deleted in Alicia mutants; somatic hypermutation/conversion may play a major role in generating the heterogeneity of rabbit heavy chain variable region sequences , 1991, European journal of immunology.
[175] R. Jessberger,et al. Repair of deletions and double-strand gaps by homologous recombination in a mammalian in vitro system , 1991, Molecular and cellular biology.
[176] W. Reeves,et al. Antigenic determinants of the Ku (p70/p80) autoantigen are poorly conserved between species. , 1990, Journal of immunology.
[177] J. Griffin,et al. Induction of RNA-stabilized DMA conformers by transcription of an immunoglobulin switch region , 1990, Nature.
[178] W. Frankel,et al. Isotype switching of an immunoglobulin heavy chain transgene occurs by DNA recombination between different chromosomes , 1990, Cell.
[179] R. A. Phillips,et al. The scid mutation in mice causes a general defect in DNA repair , 1990, Nature.
[180] M. Schlissel,et al. Wild-type V(D)J recombination in scid pre-B cells. , 1990, Molecular and cellular biology.
[181] Andreas Radbruch,et al. Protective methylation of immunoglobulin and T cell receptor (TcR) gene loci prior to induction of class switch and TcR recombination , 1990, European journal of immunology.
[182] H. Sakano,et al. Switch circular DNA formed in cytokine-treated mouse splenocytes: Evidence for intramolecular DNA deletion in immunoglobulin class switching , 1990, Cell.
[183] T. Honjo,et al. Circular DNA is excised by immunoglobulin class switch recombination , 1990, Cell.
[184] P. Jeggo,et al. Studies on mammalian mutants defective in rejoining double-strand breaks in DNA. , 1990, Mutation research.
[185] F. Blattner,et al. Immunoglobulin D switching can occur through homologous recombination in human B cells , 1990, Molecular and cellular biology.
[186] D. Schatz,et al. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. , 1990, Science.
[187] L. Su,et al. The immunoglobulin heavy-chain enhancer functions as the promoter for I mu sterile transcription , 1990, Molecular and cellular biology.
[188] M. Wabl,et al. Circular DNA is a product of the immunoglobulin class switch rearrangement , 1990, Nature.
[189] A. Barberis,et al. A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation. , 1990, Genes & development.
[190] G. Nolan,et al. A novel fluorescence-based system for assaying and separating live cells according to VDJ recombinase activity. , 1990, Molecular and cellular biology.
[191] A. Kenter,et al. Detection of an immunoglobulin switch region-specific DNA-binding protein in mitogen-stimulated mouse splenic B cells , 1990, Molecular and cellular biology.
[192] R. Becker,et al. Molecular basis of the allelic inheritance of rabbit immunoglobulin VH allotypes: Implications for the generation of antibody diversity , 1990, Cell.
[193] T. Mimori,et al. Isolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/p80) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndrome. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[194] S. Levy,et al. Idiotypic variation in a human B lymphoma cell line. , 1990, Journal of immunology.
[195] J. Stavnezer,et al. Copy choice mechanism of immunoglobulin heavy-chain switch recombination , 1990, Molecular and cellular biology.
[196] David Baltimore,et al. The V(D)J recombination activating gene, RAG-1 , 1989, Cell.
[197] P. Linton,et al. Primary antibody-forming cells and secondary B cells are generated from separate precursor cell subpopulations , 1989, Cell.
[198] J. Stavnezer,et al. A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation , 1989, Molecular and cellular biology.
[199] Jeffrey Crosbie,et al. Induction of self-tolerance in mature peripheral B lymphocytes , 1989, Nature.
[200] K. Marcu,et al. Molecular requirements for immunoglobulin heavy chain constant region gene switch-recombination revealed with switch-substrate retroviruses. , 1989, International immunology.
[201] Jean-Claude Weill,et al. Somatic hyperconversion diversifies the single VH gene of the chicken with a high incidence in the D region , 1989, Cell.
[202] R. Cook,et al. cDNA-derived amino acid sequence of the 86-kDa subunit of the Ku antigen. , 1989, The Journal of biological chemistry.
[203] Y. Kurosawa,et al. Class switch from μ to δ is mediated by homologous recombination between σμ and σμ sequences in human immunoglobulin gene loci , 1989 .
[204] D. Roth,et al. Comparison of filler DNA at immune, nonimmune, and oncogenic rearrangements suggests multiple mechanisms of formation , 1989, Molecular and cellular biology.
[205] J. Stavnezer,et al. Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch , 1989, Molecular and cellular biology.
[206] J. Petrini,et al. Products and implied mechanism of H chain switch recombination. , 1989, Journal of immunology.
[207] W. Reeves,et al. Molecular cloning of cDNA encoding the p70 (Ku) lupus autoantigen. , 1989, The Journal of biological chemistry.
[208] C. Thompson,et al. Chicken IgL gene rearrangement involves deletion of a circular episome and addition of single nonrandom nucleotides to both coding segments , 1989, Cell.
[209] Naomi Rosenberg,et al. The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination , 1988, Cell.
[210] S. Levy,et al. Mutational hot spots in Ig V region genes of human follicular lymphomas , 1988, The Journal of experimental medicine.
[211] D. Schatz,et al. The scid gene encodes a trans-acting factor that mediates the rejoining event of Ig gene rearrangement. , 1988, Genes & development.
[212] M. Wabl,et al. Looping out and deletion mechanism for the immunoglobulin heavy-chain class switch. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[213] M. Lieber,et al. Developmental stage specificity of the lymphoid V(D)J recombination activity. , 1987, Genes & development.
[214] M. Wabl,et al. High rates of deletions in the constant region segment of the immunoglobulin mu gene. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[215] C. Faust,et al. Rearrangement of rat immunoglobulin E heavy-chain and c-myc genes in the B-cell immunocytoma IR162 , 1987, Molecular and cellular biology.
[216] M. Lieber,et al. Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals , 1987, Cell.
[217] U. Krawinkel,et al. Directed Ig class switch recombination in activated murine B cells. , 1987, The EMBO journal.
[218] M. Wabl,et al. Measurements of Mutation Rates in B Lymphocytes , 1987, Immunological reviews.
[219] C. Milstein,et al. Mutation Drift and Repertoire Shift in the Maturation of the Immune Response , 1987, Immunological reviews.
[220] R. DePinho,et al. Studies on the Somatic Instability of Immunoglobulin Genes in vivo and in Cultured Cells , 1987, Immunological reviews.
[221] Klaus Rajewsky,et al. Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses , 1987, Cell.
[222] F. Alt,et al. Immunoglobulin heavy chain switch region recombination within a retroviral vector in murine pre‐B cells. , 1987, The EMBO journal.
[223] J. Weill,et al. A hyperconversion mechanism generates the chicken light chain preimmune repertoire , 1987, Cell.
[224] P. Neiman,et al. Somatic diversification of the chicken immunoglobulin light chain gene is limited to the rearranged variable gene segment , 1987, Cell.
[225] F. Alt,et al. Secondary genomic rearrangement events in pre‐B cells: VHDJH replacement by a LINE‐1 sequence and directed class switching. , 1986, The EMBO journal.
[226] D. Roth,et al. Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction , 1986, Molecular and cellular biology.
[227] M. Wabl,et al. High rate of somatic point mutation in vitro in and near the variable-region segment of an immunoglobulin heavy chain gene. , 1986, Proceedings of the National Academy of Sciences of the United States of America.
[228] J A Hardin,et al. Mechanism of interaction between Ku protein and DNA. , 1986, The Journal of biological chemistry.
[229] K. Rajewsky,et al. Class switch recombination is IgG1 specific on active and inactive IgH loci of IgG1-secreting B-cell blasts. , 1986, Proceedings of the National Academy of Sciences of the United States of America.
[230] J. Steitz,et al. Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders. , 1986, The Journal of biological chemistry.
[231] T. Kipps,et al. Homologous chromosome recombination generating immunoglobulin allotype and isotype switch variants. , 1986, The EMBO journal.
[232] S. Sirlin,et al. Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching. , 1986, The EMBO journal.
[233] D. Roth,et al. Mechanisms of nonhomologous recombination in mammalian cells , 1985, Molecular and cellular biology.
[234] G. M. Griffiths,et al. Molecular events during maturation of the immune response to oxazolone , 1985, Nature.
[235] J. Petrini,et al. Complete nucleotide sequence of the murine gamma 3 switch region and analysis of switch recombination sites in two gamma 3-expressing hybridomas. , 1985, Journal of immunology.
[236] R. Grosschedl,et al. Cell-type specificity of iminunoglobulin gene expression is regulated by at least three DNA sequence elements , 1985, Cell.
[237] L. Staudt,et al. Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin , 1985, The Journal of experimental medicine.
[238] K. Rajewsky,et al. Somatic mutation and clonal expansion of B cells in an antigen‐driven immune response. , 1985, The EMBO journal.
[239] T. Manser,et al. Influence of clonal selection on the expression of immunoglobulin variable region genes. , 1984, Science.
[240] R. Brinster,et al. Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in κ transgenic mice , 1984, Nature.
[241] J. Uhr,et al. Clonal analysis of B cells induced to secrete IgG by T cell-derived lymphokine(s) , 1984, The Journal of experimental medicine.
[242] F. Alt,et al. Molecular basis of heavy-chain class switching and switch region deletion in an Abelson virus-transformed cell line , 1984, Molecular and cellular biology.
[243] C. Milstein,et al. Somatic mutation and the maturation of immune response to 2-phenyl oxazolone , 1984, Nature.
[244] David Baltimore,et al. Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells , 1984, Nature.
[245] F. Finkelman,et al. Role of surface immunoglobulin in B lymphocyte activation. , 1984, Federation proceedings.
[246] L. Staudt,et al. Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. , 1984, Proceedings of the National Academy of Sciences of the United States of America.
[247] S. Rudikoff,et al. Somatic diversification of immunoglobulins. , 1984, Proceedings of the National Academy of Sciences of the United States of America.
[248] T. Honjo,et al. Immunoglobulin class switching , 1984, Cell.
[249] P. Jeggo,et al. X-ray-sensitive mutants of Chinese hamster ovary cell line. Isolation and cross-sensitivity to other DNA-damaging agents. , 1983, Mutation research.
[250] M. Wabl,et al. Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement , 1983, Nature.
[251] D. Bogenhagen,et al. Clusters of point mutations are found exclusively around rearranged antibody variable genes. , 1983, Proceedings of the National Academy of Sciences of the United States of America.
[252] A. Giaccia,et al. Isolation of cell cycle-dependent gamma ray-sensitive Chinese hamster ovary cell , 1983, Somatic cell genetics.
[253] A. Coutinho,et al. Intraclonal diversification in immunoglobulin isotype secretion: an analysis of switch probabilities. , 1982, The EMBO journal.
[254] K. Rajewsky,et al. Spontaneous Immunoglobulin Class Switching in Myeloma and Hybridoma Cell Lines Differs from Physiological Class Switching , 1982, Immunological reviews.
[255] Mark M. Davis,et al. Antibody diversity: Somatic hypermutation of rearranged VH genes , 1981, Cell.
[256] T. Mimori,et al. Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap. , 1981, The Journal of clinical investigation.
[257] E. Selsing,et al. Somatic mutation of immunoglobulin light-chain variable-region genes , 1981, Cell.
[258] Leroy Hood,et al. A single VH gene segment encodes the immune response to phosphorylcholine: Somatic mutation is correlated with the class of the antibody , 1981, Cell.
[259] D. Baltimore,et al. Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region , 1981, Cell.
[260] Leroy Hood,et al. IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts , 1981, Nature.
[261] N. Arnheim,et al. 5′ Flanking region of immunoglobulin heavy chain constant region genes displays length heterogeneity in germlines of inbred mouse strains , 1980, Cell.
[262] Mark M. Davis,et al. DNA sequences mediating class switching in alpha-immunoglobulins. , 1980, Science.
[263] J. Schröder,et al. Activation to IgG secretion by lipopolysaccharide requires several proliferation cycles. , 1979, Journal of immunology.
[264] J. Kearney,et al. Evidence that murine pre-B cells synthesise μ heavy chains but no light chains , 1979, Nature.
[265] S. Tonegawa,et al. Sequences of mouse immunoglobulin light chain genes before and after somatic changes , 1978, Cell.
[266] C. Milstein,et al. Expression of antibody genes in tissue culture: structural mutants and hybrid cells. , 1978, National Cancer Institute monograph.
[267] J. Kearney,et al. B lymphocyte differentiation induced by lipopolysaccharide. I. Generation of cells synthesizing four major immunoglobulin classes. , 1975, Journal of immunology.
[268] A. Cunningham,et al. Antibody cell daughters can produce antibody of different specificities , 1974, Nature.
[269] T. Malek,et al. Recombinant rabbit secretory immunoglobulin molecules: alpha chains with maternal (paternal) variable-region allotypes and paternal (maternal) constant-region allotypes. , 1974, Proceedings of the National Academy of Sciences of the United States of America.
[270] P. Coffino,et al. Mutations in Immunoglobulin-Producing Moose Myeloma Cells , 1973, Science.
[271] C. Steinberg,et al. Inheritance of spontaneous mutability in yeast. , 1971, Genetics.
[272] M. Cohn,et al. Variability in the Lambda Light Chain Sequences of Mouse Antibody , 1970, Nature.
[273] S. Brenner,et al. Origin of Antibody Variation , 1966, Nature.
[274] Joshua. Genes and Antibodies Do antigens bear instructions for antibody specificity or do they select cell lines that arise by mutation ? , 1998 .
[275] C. Milstein,et al. Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. , 1995, Nature.
[276] Melanie R. Wilson,et al. Somatic Mutations During an Immune Response in Xenopus Tadpoles , 1995, Developmental immunology.
[277] E. E. Max,et al. The role of BSAP in immunoglobulin isotype switching and B-cell proliferation. , 1995, Current topics in microbiology and immunology.
[278] F. Alt,et al. Expression of I mu-C gamma hybrid germline transcripts subsequent to immunoglobulin heavy chain class switching. , 1994, International Immunology.
[279] J. Banchereau,et al. The CD40 antigen and its ligand. , 1994, Annual review of immunology.
[280] S. Lewis,et al. The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses. , 1994, Advances in immunology.
[281] M. Mattei,et al. Expression of the developmental I antigen by a cloned human cDNA encoding a member of a beta-1,6-N-acetylglucosaminyltransferase gene family. , 1993, Genes & development.
[282] R. Geha,et al. Regulation of isotype switching. , 1993, Current opinion in immunology.
[283] M. Wabl,et al. Immunoglobulin class switch recombination. , 1993, Annual review of immunology.
[284] R. Coffman,et al. Mechanism and regulation of immunoglobulin isotype switching. , 1993, Advances in immunology.
[285] L. Pasquier,et al. PHYLOGENY OF B-CELL DEVELOPMENT , 1993 .
[286] C. Goodnow. Transgenic mice and analysis of B-cell tolerance. , 1992, Annual review of immunology.
[287] D. Schatz,et al. V(D)J recombination: molecular biology and regulation. , 1992, Annual review of immunology.
[288] F. Alt,et al. Activities involved in V(D)J recombination. , 1992, Current topics in microbiology and immunology.
[289] M. Gellert,et al. Molecular analysis of V(D)J recombination. , 1992, Annual review of genetics.
[290] J. Menetski,et al. V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes. , 1992, Cell.
[291] R. Becker,et al. Restricted utilization of germ-line VH genes in rabbits: implications for inheritance of VH allotypes and generation of antibody diversity. , 1991, Advances in experimental medicine and biology.
[292] A. Giaccia,et al. P14 06 MP – THE SCID MUTATION IN MICE CONFERS HYPERSENSITIVITY TO IONIZING RADIATION AND A DEFICIENCY IN DNA DOUBLE STRAND BREAK REPAIR , 1991 .
[293] A. Carroll,et al. The SCID mouse mutant: definition, characterization, and potential uses. , 1991, Annual review of immunology.
[294] T. Manser,et al. The efficiency of antibody affinity maturation: can the rate of B-cell division be limiting? , 1990, Immunology today.
[295] F. Mills,et al. Sequences of human immunoglobulin switch regions: implications for recombination and transcription. , 1990, Nucleic acids research.
[296] Andreas Radbruch,et al. Immunoglobulin class switching: molecular and cellular analysis. , 1990, Annual review of immunology.
[297] N. Maizels. Might gene conversion be the mechanism of somatic hypermutation of mammalian immunoglobulin genes? , 1989, Trends in genetics : TIG.
[298] R. Jessberger,et al. Recombination between adenovirus DNA and the mammalian genome. , 1989, Current topics in microbiology and immunology.
[299] L. Liu,et al. DNA topoisomerase poisons as antitumor drugs. , 1989, Annual review of biochemistry.
[300] M. Wabl,et al. Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line. , 1985, Proceedings of the National Academy of Sciences of the United States of America.
[301] R. Camerini-Otero,et al. A pattern of partially homologous recombination in mouse L cells. , 1984, Proceedings of the National Academy of Sciences of the United States of America.
[302] W. Doerfler,et al. On the mechanism of recombination between adenoviral and cellular DNAs: the structure of junction sites. , 1984, Current topics in microbiology and immunology.
[303] M. Wabl,et al. Expression of mu and gamma immunoglobulin heavy chains in different cells of a cloned mouse lymphoid line. , 1981, Proceedings of the National Academy of Sciences of the United States of America.
[304] L. Forni,et al. Synthesis of multiple immunoglobulin classes by single lymphocytes. , 1977, Cold Spring Harbor symposia on quantitative biology.
[305] P. Coffino,et al. Rate of somatic mutation in immunoglobulin production by mouse myeloma cells. , 1971, Proceedings of the National Academy of Sciences of the United States of America.