Imaging and Evaluating the Elastic Properties of Biological Tissues

It is well known that changes in elasticity of soft tissues are often related to pathology. Physicians traditionally use sound as a diagnostic tool, for example, by tapping on the patient's body. Vibro-acoustography implements the same concept but in micro-scale, and in a way that can be applied to living tissues. This method uses a small point-like tapping force that vibrates a region within the body, while a sensitive microphone is used to listen to the "sound" of the vibrating region.

[1]  J. Greenleaf,et al.  Ultrasound-stimulated vibro-acoustic spectrography. , 1998, Science.

[2]  J F Greenleaf,et al.  Vibro-acoustography: an imaging modality based on ultrasound-stimulated acoustic emission. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[3]  J F Greenleaf,et al.  Probing the dynamics of tissue at low frequencies with the radiation force of ultrasound. , 2000, Physics in medicine and biology.