Screening of Phellinus linteus, a medicinal mushroom, for anti-viral activity

Harmful viruses, including dengue virus, human immunodeficiency virus, and hepatitis B virus are known to be extremely sensitive to glucosidase inhibition. Phellinus linteus, an edible medicinal mushroom, was screened as an α-glucosidase inhibitor. The methanol extract of P. Linteus inhibited the trafficking process of Newcastle disease virus-hemagglutinin-neuramidase, a viral glycoprotein, in virus-infected baby hamster kidney cells. These results suggest that P. Linteus extract inhibits viral glycoprotein expression on cell surface through inhibition of trafficking process rather than glycoprotein synthesis.

[1]  Chieh-Hsi Wu,et al.  Hispolon from Phellinus linteus has antiproliferative effects via MDM2-recruited ERK1/2 activity in breast and bladder cancer cells. , 2009, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[2]  T. Quinn HIV epidemiology and the effects of antiviral therapy on long-term consequences , 2008, AIDS.

[3]  Sung-Hoon Kim,et al.  A medicinal mushroom: Phellinus linteus. , 2008, Current medicinal chemistry.

[4]  H. Katsuta,et al.  [Alpha glucosidase inhibitor]. , 2020, Nihon rinsho. Japanese journal of clinical medicine.

[5]  N. Asano Glycosidase inhibitors: update and perspectives on practical use. , 2003, Glycobiology.

[6]  A. Takatsuki,et al.  Mepanipyrim, a Novel Inhibitor of Pharmacologically Induced Golgi Dispersion , 2003, Bioscience, biotechnology, and biochemistry.

[7]  M. Kieny,et al.  The alpha-glucosidase inhibitor 1-deoxynojirimycin blocks human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step. , 2002, Molecular pharmacology.

[8]  Sang-Han Lee,et al.  Genistein, a soy isoflavone, is a potent α‐glucosidase inhibitor , 2001 .

[9]  P. Desprès,et al.  α-Glucosidase Inhibitors Reduce Dengue Virus Production by Affecting the Initial Steps of Virion Morphogenesis in the Endoplasmic Reticulum , 2000, Journal of Virology.

[10]  D. Einfeld Maturation and assembly of retroviral glycoproteins. , 1996, Current topics in microbiology and immunology.

[11]  R. Dwek,et al.  The alpha-glucosidase inhibitor N-butyldeoxynojirimycin inhibits human immunodeficiency virus entry at the level of post-CD4 binding , 1995, Journal of virology.

[12]  M. Yamasaki,et al.  Folimycin (concanamycin A), an inhibitor of V-type H(+)-ATPase, blocks cell-surface expression of virus-envelope glycoproteins. , 1993, Biochemical and Biophysical Research Communications - BBRC.

[13]  B. Walker,et al.  Synergistic inhibition of human immunodeficiency virus type 1 and type 2 replication in vitro by castanospermine and 3'-azido-3'-deoxythymidine , 1989, Antimicrobial Agents and Chemotherapy.

[14]  H. Ploegh,et al.  Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase , 1987, Nature.

[15]  R. Kerbel,et al.  Beta 1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis. , 1987, Science.