Advanced Strategies for the Efficient Production of Squalene by Microbial Fermentation

[1]  C. S. Lin,et al.  Efficient production of the β-ionone aroma compound from organic waste hydrolysates using an engineered Yarrowia lipolytica strain , 2022, Frontiers in Microbiology.

[2]  Yimeng Zuo,et al.  Establishing Komagataella phaffii as a Cell Factory for Efficient Production of Sesquiterpenoid α-Santalene. , 2022, Journal of agricultural and food chemistry.

[3]  Yinghua Lu,et al.  Genetic regulation and fermentation strategy for squalene production in Schizochytrium sp. , 2022, Applied Microbiology and Biotechnology.

[4]  Qipeng Yuan,et al.  Design of stable and self-regulated microbial consortia for chemical synthesis , 2022, Nature Communications.

[5]  U. Rova,et al.  Structural and Molecular Characterization of Squalene Synthase Belonging to the Marine Thraustochytrid Species Aurantiochytrium limacinum Using Bioinformatics Approach , 2022, Marine drugs.

[6]  Jia Li,et al.  Metabolic Division in an Escherichia coli Coculture System for Efficient Production of Kaempferide. , 2022, ACS synthetic biology.

[7]  Y. Choi,et al.  High-Level Squalene Production from Methane Using a Metabolically Engineered Methylomonas sp. DH-1 Strain , 2021, ACS Sustainable Chemistry & Engineering.

[8]  P. Elsner,et al.  Point mutations in the squalene epoxidase erg1 and sterol 14‐α demethylase erg11 gene of T indotineae isolates indicate that the resistant mutant strains evolved independently , 2021, Mycoses.

[9]  Jingrun Ye,et al.  Morphological and Metabolic Engineering of Yarrowia lipolytica to Increase β-Carotene Production. , 2021, ACS synthetic biology.

[10]  Bei Gao,et al.  Metabolic compartmentalization in yeast mitochondria: Burden and solution for squalene overproduction. , 2021, Metabolic engineering.

[11]  Xiaoyong He,et al.  Engineering of cis-Element in Saccharomyces cerevisiae for Efficient Accumulation of Value-Added Compound Squalene via Downregulation of the Downstream Metabolic Flux. , 2021, Journal of agricultural and food chemistry.

[12]  S. Jung,et al.  Comparative study on antigen persistence and immunoprotective efficacy of intramuscular and intraperitoneal injections of squalene - aluminium hydroxide (Sq + Al) adjuvanted viral hemorrhagic septicaemia virus vaccine in olive flounder (Paralichthys olivaceus). , 2021, Vaccine.

[13]  Weiguo Zhang,et al.  Dual Regulation of Cytoplasm and Peroxisomes for Improved Α-Farnesene Production in Recombinant Pichia pastoris. , 2021, ACS synthetic biology.

[14]  G. Shi,et al.  Overproduction of α-Farnesene in Saccharomyces cerevisiae by Farnesene Synthase Screening and Metabolic Engineering. , 2021, Journal of agricultural and food chemistry.

[15]  Sarma Mutturi,et al.  Adaptive evolution of engineered yeast for squalene production improvement and its genome‐wide analysis , 2021, Yeast.

[16]  M. Jiang,et al.  Recent Advances on Biological Synthesis of Lycopene by Using Industrial Yeast , 2021 .

[17]  S. Shakeri,et al.  Rhodosporidium sp. DR37: a novel strain for production of squalene in optimized cultivation conditions , 2021, Biotechnology for Biofuels.

[18]  Xiangyang Lu,et al.  Metabolic engineering of Yarrowia lipolytica for improving squalene production. , 2021, Bioresource technology.

[19]  H. L. Anh,et al.  Optimization of culture conditions for squalene production and squalene extraction method of Thraustochytrium<\i> sp. TN22 , 2020, Academia Journal of Biology.

[20]  Fang Wang,et al.  Genetic and bioprocess engineering to improve squalene production in Yarrowia lipolytica , 2020, Bioresource technology.

[21]  Seung Soo Oh,et al.  Engineering cell wall integrity enables enhanced squalene production in yeast. , 2020, Journal of agricultural and food chemistry.

[22]  W. Quax,et al.  Production of Squalene in Bacillus subtilis by Squalene Synthase Screening and Metabolic Engineering , 2020, Journal of agricultural and food chemistry.

[23]  P. Lindberg,et al.  Introduction of a green algal squalene synthase enhances squalene accumulation in a strain of Synechocystis sp. PCC 6803 , 2020, Metabolic engineering communications.

[24]  U. Rova,et al.  Co-production of DHA and squalene by thraustochytrid from forest biomass , 2020, Scientific Reports.

[25]  N. Riaz,et al.  Self-Redirection of Metabolic Flux toward Squalene and Ethanol Pathways by Engineered Yeast , 2020, Metabolites.

[26]  Bei Gao,et al.  Metabolic engineering of Saccharomyces cerevisiae to overproduce squalene. , 2020, Journal of agricultural and food chemistry.

[27]  W. Zhou,et al.  The yeast peroxisome: A dynamic storage depot and subcellular factory for squalene overproduction. , 2019, Metabolic engineering.

[28]  S. Han,et al.  Redesign and reconstruction of a mevalonate pathway and its application in terpene production in Escherichia coli , 2019, Bioresource Technology Reports.

[29]  Guangyi Wang,et al.  Bio-based squalene production by Aurantiochytrium sp. through optimization of culture conditions, and elucidation of the putative biosynthetic pathway genes. , 2019, Bioresource technology.

[30]  Sarma Mutturi,et al.  Systems-based Saccharomyces cerevisiae strain design for improved squalene synthesis , 2019, Biochemical Engineering Journal.

[31]  M. Koffas,et al.  Advances in the development and application of microbial consortia for metabolic engineering , 2019, Metabolic engineering communications.

[32]  Wen Xu,et al.  Improving squalene production by enhancing the NADPH/NADP+ ratio, modifying the isoprenoid-feeding module and blocking the menaquinone pathway in Escherichia coli , 2019, Biotechnology for Biofuels.

[33]  Jianyu Fu,et al.  Squalene synthase cloning and functional identification in wintersweet plant (Chimonanthus zhejiangensis) , 2018, Botanical Studies.

[34]  J. Y. Lee,et al.  Rerouting of NADPH synthetic pathways for increased protopanaxadiol production in Saccharomyces cerevisiae , 2018, Scientific Reports.

[35]  E. Toledo,et al.  Squalene Stimulates a Key Innate Immune Cell to Foster Wound Healing and Tissue Repair , 2018, Evidence-based complementary and alternative medicine : eCAM.

[36]  Q. Hua,et al.  Enhanced squalene biosynthesis in Yarrowia lipolytica based on metabolically engineered acetyl-CoA metabolism. , 2018, Journal of biotechnology.

[37]  F. Niu,et al.  Enhancing Production of Pinene in Escherichia coli by Using a Combination of Tolerance, Evolution, and Modular Co-culture Engineering , 2018, Front. Microbiol..

[38]  Yong-Su Jin,et al.  Improved squalene production through increasing lipid contents in Saccharomyces cerevisiae , 2018, Biotechnology and bioengineering.

[39]  J. Osada,et al.  Current Insights into the Biological Action of Squalene , 2018, Molecular nutrition & food research.

[40]  Hongweon Lee,et al.  High-level recombinant production of squalene using selected Saccharomyces cerevisiae strains , 2018, Journal of Industrial Microbiology & Biotechnology.

[41]  Qinggele Caiyin,et al.  Heterologous biosynthesis of triterpenoid ambrein in engineered Escherichia coli , 2018, Biotechnology Letters.

[42]  Sarma Mutturi,et al.  Regeneration of NADPH Coupled with HMG-CoA Reductase Activity Increases Squalene Synthesis in Saccharomyces cerevisiae. , 2017, Journal of agricultural and food chemistry.

[43]  G. Dávila-Ortíz,et al.  Squalene Extraction: Biological Sources and Extraction Methods , 2017 .

[44]  Chaoyin Chen,et al.  Enhancement of triterpenoid saponins biosynthesis in Panax notoginseng cells by co-overexpressions of 3-hydroxy-3-methylglutaryl CoA reductase and squalene synthase genes , 2017 .

[45]  D. Cane,et al.  Exploring the Influence of Domain Architecture on the Catalytic Function of Diterpene Synthases. , 2017, Biochemistry.

[46]  K. Miyashita,et al.  Squalene modulates fatty acid metabolism: Enhanced EPA/DHA in obese/diabetic mice (KK‐Ay) model , 2016 .

[47]  C. Ching,et al.  Mitochondrial acetyl-CoA utilization pathway for terpenoid productions. , 2016, Metabolic engineering.

[48]  Wen Xu,et al.  Production of squalene by microbes: an update , 2016, World journal of microbiology & biotechnology.

[49]  C. Li,et al.  Overproduction of squalene synergistically downregulates ethanol production in Saccharomyces cerevisiae , 2016 .

[50]  Haoran Zhang,et al.  Modular co-culture engineering, a new approach for metabolic engineering. , 2016, Metabolic engineering.

[51]  Wen Xu,et al.  Metabolic engineering of Rhodopseudomonas palustris for squalene production , 2016, Journal of Industrial Microbiology & Biotechnology.

[52]  I. Hapala,et al.  Production of squalene by lactose‐fermenting yeast Kluyveromyces lactis with reduced squalene epoxidase activity , 2015, Letters in applied microbiology.

[53]  O. Popa,et al.  Methods for Obtaining and Determination of Squalene from Natural Sources , 2015, BioMed research international.

[54]  G. Stephanopoulos,et al.  Distributing a metabolic pathway among a microbial consortium enhances production of natural products , 2015, Nature Biotechnology.

[55]  I. Hapala,et al.  Squalene epoxidase as a target for manipulation of squalene levels in the yeast Saccharomyces cerevisiae. , 2014, FEMS yeast research.

[56]  Masaki Yoshida,et al.  TLC screening of thraustochytrid strains for squalene production , 2013, Journal of Applied Phycology.

[57]  E. Radisky,et al.  Squalene synthase: steady-state, pre-steady-state, and isotope-trapping studies. , 2000, Biochemistry.

[58]  Y. Masuyama,et al.  Hexacarbonylmolybdenum(0)-catalyzed reductive coupling of allylic acetates. , 1987 .

[59]  K. Iguchi,et al.  Reaction of organic halides with chlorotris-(triphenylphosphine)cobalt(I) , 1984 .

[60]  R. Ebersole,et al.  Mechanism of squalene cyclization: the chiral origin of the C-7 and C-15 hydrogen atoms of fusidic acid. , 1973, Journal of steroid biochemistry.

[61]  J. Lynch,et al.  Steroids and Squalene in Methylococcus capsulatus grown on Methane , 1971, Nature.

[62]  D. Barton,et al.  Biosynthesis of terpenes and steroids. Part III. Squalene cyclisation in the biosynthesis of triterpenoids; the biosynthesis of fern-9-ene in Polypodium vulgare Linn , 1971 .

[63]  W. S. Johnson,et al.  Application of the chloro ketal Claisen reaction to the total synthesis of squalene. , 1970, Proceedings of the National Academy of Sciences of the United States of America.