Cutaneous metastasis of extraskeletal osteosarcoma arising in the mediastinum.

Cutaneous metastases have been reported in 5%-10% of patients with internal malignancy. The most common clinical features are the sudden appearance of discrete, firm, and nontender nodules in a particular area of the body. The most frequent metastatic site of extraskeletal osteosarcoma (ESOS) is the lungs. Cutaneous metastasis of ESOS is rare. To our knowledge, only one case of ESOS has been reported with skin metastasis, histopathologically classified as the osteoblastic subtype. Here, we describe a case of chondroblastic ESOS arising in the mediastinum with metastasis to the skin. Our patient presented with a scalp nodule after diagnosis of primary ESOS at the mediastinum.

[1]  Jason B. Lee,et al.  A case of extraskeletal osteosarcoma with metastasis to the skin. , 2003, Journal of the American Academy of Dermatology.

[2]  H. J. Wang,et al.  Thymic sarcomatoid carcinoma with skeletal muscle differentiation: report of two cases, one with cytogenetic analysis , 2002, Histopathology.

[3]  P. Terrier,et al.  Extraskeletal osteosarcoma of the mediastinum after treatment of a mediastinal germ-cell tumor. , 1999, American journal of clinical oncology.

[4]  K. Sahu,et al.  Extraskeletal osteosarcoma. , 1997, Journal of the Indian Medical Association.

[5]  Y. Beppu,et al.  Extraskeletal osteosarcoma: a clinicopathologic study of four cases. , 1995, Japanese journal of clinical oncology.

[6]  R. Moser.  Musculoskeletal case of the day. Extraskeletal osteosarcoma of the thigh. , 1994, AJR. American journal of roentgenology.

[7]  T. Kuo.  Primary osteosarcoma of the skin , 1992, Journal of cutaneous pathology.

[8]  Green Sm,et al.  Extraskeletal osteogenic sarcoma of the mediastinum. , 1989 .

[9]  S. Greenwood,et al.  Extraskeletal osteogenic sarcoma of the mediastinum. , 1989, Archives of pathology & laboratory medicine.

[10]  D. Resnick,et al.  Tumors and tumor like lesions of bone imaging and pathology of specific lesions , 1988 .

[11]  J. Hättenschwiler,et al.  Primary osteosarcoma of the liver , 1987, Cancer.

[12]  L. Kahn,et al.  Extraskeletal osteosarcoma arising in an ectopic hamartomatous thymus: Report of a case and review of the literature , 1983, Cancer.

[13]  W Russe,et al.  [Osteogenic sarcoma]. , 1983, ZFA. Zeitschrift fur Allgemeinmedizin.

[14]  J Burston,et al.  Respiratory Medicine , 1982 .

[15]  A. Huvos.  Bone tumors, diagnosis, treatment, and prognosis , 1979 .

[16]  K. Kikuchi,et al.  Primary osteogenic sarcoma of the mediastinum , 1974, Thorax.

[17]  M. Dintsman,et al.  Extraosseous osteogenic sarcoma. , 1974, Clinical orthopaedics and related research.

[18]  C. Allan,et al.  Osteogenic sarcoma of the somatic soft tissues. Clinicopathologic study of 26 cases and review of literature , 1971, Cancer.

[19]  L. Preger,et al.  Extraosseous osteogenic sarcoma of the chest. , 1969, British journal of diseases of the chest.

[20]  A. Stout,et al.  Osteogenic sarcoma of the extraskeletal soft tissues , 1956, Cancer.

[21]  Stauss Hk.  Osteogenic sarcoma arising in traumatic hemothorax and hematoma of the thoracic wall. , 1951 .

[22]  H. Stauss.  Osteogenic sarcoma arising in traumatic hemothorax and hematoma of the thoracic wall. , 1951, Surgery.

[23]  H. Wilson.  EXTRASKELETAL OSSIFYING TUMORS , 1941, Annals of surgery.

[24]  R. M.,et al.  The Thyroid Gland , 1894, Nature.