Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.
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C W Turck | C. Turck | J. Chen | S. Coughlin | A. Tulinsky | I. Mathews | J W Fenton | A Tulinsky | K. Padmanabhan | J. Fenton | J Chen | I I Mathews | K P Padmanabhan | S R Coughlin | V Ganesh | M Ishii | M. Ishii | V. Ganesh
[1] H Oschkinat,et al. The interaction of thrombin with fibrinogen. A structural basis for its specificity. , 1992, European journal of biochemistry.
[2] B. Finzel. Incorporation of fast Fourier transforms to speed restrained least‐squares refinement of protein structures , 1987 .
[3] Mary L. Westbrook,et al. Structure of the hirugen and hirulog 1 complexes of alpha-thrombin. , 1991 .
[4] V. Wheaton,et al. Domains specifying thrombin–receptor interaction , 1991, Nature.
[5] R. Feinman,et al. Interrelations of platelet aggregation and secretion. , 1977, The Journal of clinical investigation.
[6] W. Bode,et al. Crystal structure of the thrombin‐hirudin complex: a novel mode of serine protease inhibition. , 1990, The EMBO journal.
[7] G. Eichele,et al. Diffraction methods for biological macromolecules. Seed enlargement and repeated seeding. , 1985, Methods in enzymology.
[8] J. Sheehan,et al. Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombin. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[9] C. Esmon,et al. Glu-192----Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[10] R. Huber,et al. The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution. , 1994, The Journal of biological chemistry.
[11] E. Lüscher,et al. Release reactions of human platelets induced by thrombin and other agents. , 1968, Biochimica et biophysica acta.
[12] J. Maraganore,et al. Hirulog peptides with scissile bond replacements resistant to thrombin cleavage. , 1991, Biochemical and biophysical research communications.
[13] J. Maraganore,et al. Anticoagulant activity of synthetic hirudin peptides. , 1989, The Journal of biological chemistry.
[14] Solution structure of a platelet receptor peptide bound to bovine alpha-thrombin. , 1992, Biochemistry.
[15] A. Tulinsky,et al. Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors. , 1994, Biochemistry.
[16] H Brandstetter,et al. Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics. , 1992, Journal of molecular biology.
[17] J. Fenton,et al. Analysis of the secondary structure of hirudin and the mechanism of its interaction with thrombin. , 1988, Archives of biochemistry and biophysics.
[18] M. Zabinski,et al. Anion-binding exosite of human alpha-thrombin and fibrin(ogen) recognition. , 1988, Biochemistry.
[19] B. Kobilka,et al. Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling. , 1993, The Journal of biological chemistry.
[20] C. Esmon,et al. The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity. , 1991, The Journal of biological chemistry.
[21] Robert Huber,et al. The refined 1.9 A crystal structure of human alpha‐thrombin: interaction with D‐Phe‐Pro‐Arg chloromethylketone and significance of the Tyr‐Pro‐Pro‐Trp insertion segment. , 1989 .
[22] R. Huber,et al. The structure of a complex of recombinant hirudin and human alpha-thrombin. , 1990, Science.
[23] Barry C. Finzel,et al. The use of an imaging proportional counter in macromolecular crystallography , 1987 .
[24] A Tulinsky,et al. Structures of thrombin complexes with a designed and a natural exosite peptide inhibitor. , 1993, The Journal of biological chemistry.
[25] Axel T. Brunger,et al. Extension of molecular replacement: a new search strategy based on Patterson correlation refinement , 1990 .
[26] D. Turk,et al. The refined 1.9‐Å X‐ray crystal structure of d‐Phe‐Pro‐Arg chloromethylketone‐inhibited human α‐thrombin: Structure analysis, overall structure, electrostatic properties, detailed active‐site geometry, and structure‐function relationships , 1992, Protein science : a publication of the Protein Society.
[27] R. Huber,et al. Refined structure of the hirudin-thrombin complex. , 1991, Journal of molecular biology.
[28] J. Maraganore,et al. Design and characterization of hirulogs: a novel class of bivalent peptide inhibitors of thrombin. , 1990, Biochemistry.
[29] K C Nicolaou,et al. Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[30] W. Hendrickson. Stereochemically restrained refinement of macromolecular structures. , 1985, Methods in enzymology.
[31] V. Wheaton,et al. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation , 1991, Cell.
[32] J. Maraganore,et al. Thrombin-specific inhibition by and slow cleavage of hirulog-1. , 1992, The Biochemical journal.