Decreased habituation of midlatency auditory evoked responses in parkinson's disease

The PI midlatency auditory evoked potential was studied in patients with Parkinson's disease and compared to that in age‐matched controls. Habituation of the potential was determined by using a two‐click stimulus paradigm in which the stimuli were presented at 250‐, 500‐, and 1,000‐ms inter‐stimulus intervals. Results showed that habituation of the PI potential had a statistically significant decrease at the 250‐ms and 500‐ms interstimulus intervals in patients with Parkinson's disease compared to normal controls. The degree of decreased habituation was found to increase with severity of the disease such that stage 5 patients showed greater decreases in habituation compared to stage 4, as did stage 4 compared to stage 3. These findings may be explained by the presence of a dysregulation of sensory processing, possibly by elements of the reticular activating system, including the pedunculopontine nucleus, in Parkinson's disease.

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