Alteration of host cell phenotype by Theileria annulata and Theileria parva: mining for manipulators in the parasite genomes.

[1]  B. Shiels,et al.  Infection of bovine cells by the protozoan parasite Theileria annulata modulates expression of the ISGylation system , 2006, Cellular microbiology.

[2]  M. Chaussepied,et al.  Taking the Myc is bad for Theileria. , 2005, Trends in parasitology.

[3]  Jonathan E. Allen,et al.  Genome Sequence of Theileria parva, a Bovine Pathogen That Transforms Lymphocytes , 2005, Science.

[4]  Neil Hall,et al.  Genome of the Host-Cell Transforming Parasite Theileria annulata Compared with T. parva , 2005, Science.

[5]  L. Murphy,et al.  Prohibitin: a potential target for new therapeutics. , 2005, Trends in molecular medicine.

[6]  Michael Karin,et al.  Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases , 2005, Cell.

[7]  D. Werling,et al.  c-Myc activation by Theileria parasites promotes survival of infected B-lymphocytes , 2005, Oncogene.

[8]  N. Katunuma,et al.  Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells. , 2005, The journal of medical investigation : JMI.

[9]  M. Mota,et al.  Survival of protozoan intracellular parasites in host cells , 2004, EMBO Reports.

[10]  D. Dobbelaere,et al.  The strategies of the Theileria parasite: a new twist in host-pathogen interactions. , 2004, Current opinion in immunology.

[11]  S. Brunak,et al.  Improved prediction of signal peptides: SignalP 3.0. , 2004, Journal of molecular biology.

[12]  C. Scheidereit,et al.  Requirement of Hsp90 activity for IκB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-κB activation , 2004, Oncogene.

[13]  M. Abdelhaleem Do human RNA helicases have a role in cancer? , 2004, Biochimica et biophysica acta.

[14]  M. Bjornsti,et al.  The tor pathway: a target for cancer therapy , 2004, Nature Reviews Cancer.

[15]  K. Lu Pinning down cell signaling, cancer and Alzheimer's disease. , 2004, Trends in biochemical sciences.

[16]  Joseph R. Nevins,et al.  A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells , 2004, Nature Cell Biology.

[17]  A Theileria annulata DNA Binding Protein Localized to the Host Cell Nucleus Alters the Phenotype of a Bovine Macrophage Cell Line , 2004, Eukaryotic Cell.

[18]  E. Robertson,et al.  Epstein-Barr Virus Nuclear Antigen 3C Regulates Cyclin A/p27 Complexes and Enhances Cyclin A-Dependent Kinase Activity , 2004, Journal of Virology.

[19]  P. Workman Altered states: selectively drugging the Hsp90 cancer chaperone. , 2004, Trends in molecular medicine.

[20]  A. Ryo,et al.  Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. , 2003, Molecular cell.

[21]  M. Hoffs,et al.  TashHN, a Theileria annulata encoded protein transported to the host nucleus displays an association with attenuation of parasite differentiation , 2003, Cellular microbiology.

[22]  J. Ahmed,et al.  Initiation of translation and cellular localization of Theileria annulata casein kinase IIα: Implication for its role in host cell transformation , 2003, Journal of cellular physiology.

[23]  S. Rottenberg,et al.  Theileria-induced leukocyte transformation. , 2003, Current opinion in microbiology.

[24]  Yong J. Lee,et al.  Differential role of glutaredoxin and thioredoxin in metabolic oxidative stress-induced activation of apoptosis signal-regulating kinase 1. , 2003, The Biochemical journal.

[25]  Christopher J. Tonkin,et al.  Dissecting Apicoplast Targeting in the Malaria Parasite Plasmodium falciparum , 2003, Science.

[26]  Zhijian J. Chen,et al.  Hijacking of Host Cell IKK Signalosomes by the Transforming Parasite Theileria , 2002, Science.

[27]  G. Filomeni,et al.  Cell signalling and the glutathione redox system. , 2002, Biochemical pharmacology.

[28]  G. Berchem,et al.  Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis , 2002, Oncogene.

[29]  R. Rosell,et al.  Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers. , 2002, Biochemical and biophysical research communications.

[30]  Jose M. Silva,et al.  Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy , 2002, Oncogene.

[31]  D. Goeddel,et al.  TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. , 2002, Molecular cell.

[32]  A. Tait,et al.  TaCRK3 encodes a novel Theileria annulata protein kinase with motifs characteristic of the family of eukaryotic cyclin dependent kinases: a comparative analysis of its expression with TaCRK2 during the parasite life cycle. , 2001, Gene.

[33]  M. Cleary,et al.  Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins , 2001, Oncogene.

[34]  S. Rottenberg,et al.  Inhibition of apoptosis by intracellular protozoan parasites. , 2001, International journal for parasitology.

[35]  B. Hemmings,et al.  The Akt/PKB pathway is constitutively activated in Theileria‐transformed leucocytes, but does not directly control constitutive NF‐κB activation , 2001, Cellular microbiology.

[36]  R. Stern,et al.  Characterisation of a cluster of genes encoding Theileria annulata AT hook DNA-binding proteins and evidence for localisation to the host cell nucleus. , 2001, Journal of cell science.

[37]  A. Krogh,et al.  Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. , 2001, Journal of molecular biology.

[38]  B. Rost,et al.  Finding nuclear localization signals , 2000, EMBO reports.

[39]  M. Chaussepied,et al.  Constitutive PI3‐K activity is essential for proliferation, but not survival, of Theileria parva‐transformed B cells , 2000, Cellular microbiology.

[40]  S. Brunak,et al.  Predicting subcellular localization of proteins based on their N-terminal amino acid sequence. , 2000, Journal of molecular biology.

[41]  A. Shilatifard,et al.  The amino terminus of the mixed lineage leukemia protein (MLL) promotes cell cycle arrest and monocytic differentiation. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[42]  G. Langsley,et al.  Loss of matrix metalloproteinase 9 activity in Theileria annulata-attenuated cells is at the transcriptional level and is associated with differentially expressed AP-1 species. , 2000, Molecular and biochemical parasitology.

[43]  N. Jones,et al.  Viral-encoded cyclins. , 2000, Current opinion in genetics & development.

[44]  P. Bork,et al.  Prediction of potential GPI-modification sites in proprotein sequences. , 1999, Journal of molecular biology.

[45]  A. Tait,et al.  Evidence for localisation of a Theileria parasite AT hook DNA-binding protein to the nucleus of immortalised bovine host cells. , 1999, Molecular and biochemical parasitology.

[46]  H. Mehlhorn,et al.  Review: Theileria schizonts induce fundamental alterations in their host cells , 1999, Parasitology Research.

[47]  V. Heussler,et al.  Transformation of leukocytes by Theileria parva and T. annulata. , 1999, Annual review of microbiology.

[48]  K. Nakai,et al.  PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization. , 1999, Trends in biochemical sciences.

[49]  D. Landsman,et al.  AT-hook motifs identified in a wide variety of DNA-binding proteins. , 1998, Nucleic acids research.

[50]  M. Chaussepied,et al.  Upregulation of Jun and Fos family members and permanent JNK activity lead to constitutive AP-1 activation in Theileria-transformed leukocytes. , 1998, Molecular and biochemical parasitology.

[51]  V. Heussler,et al.  Parasite-mediated nuclear factor kappaB regulation in lymphoproliferation caused by Theileria parva infection. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[52]  R. Adamson,et al.  A role for matrix metalloproteinases in the pathology and attenuation of Theileria annulata infections. , 1997, Parasitology today.

[53]  Thomas L. Madden,et al.  Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. , 1997, Nucleic acids research.

[54]  D. Dobbelaere,et al.  Jun NH2-terminal kinase is constitutively activated in T cells transformed by the intracellular parasite Theileria parva. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[55]  M. Shaw,et al.  The same but different: the biology of Theileria sporozoite entry into bovine cells. , 1997, International journal for parasitology.

[56]  L. Johnston,et al.  An unwelcome partner: parasitic choreography of the host cell cycle? , 1997, Trends in microbiology.

[57]  D. Dobbelaere,et al.  Macrophage‐parasite relationship in theileriosis. Reversible phenotypic and functional dedifferentiation of macrophages infected with Theileria annulata , 1997, Journal of leukocyte biology.

[58]  M. Logan,et al.  The isolation and characterization of genomic and cDNA clones coding for a cdc2‐related kinase (ThCRK2) from the bovine protozoan parasite Theileria , 1996, Molecular microbiology.

[59]  S. Rogers,et al.  PEST sequences and regulation by proteolysis. , 1996, Trends in biochemical sciences.

[60]  T. Cavalier-smith,et al.  Phylogeny and evolution of the piroplasms , 1994, Parasitology.

[61]  O. ole-MoiYoi,et al.  Evidence for the induction of casein kinase II in bovine lymphocytes transformed by the intracellular protozoan parasite Theileria parva. , 1993, The EMBO journal.

[62]  A. Tait,et al.  Theileria annulata: alterations in phosphoprotein and protein kinase activity profiles of infected leukocytes of the bovine host, Bos taurus. , 1992, Experimental parasitology.

[63]  L. G. Tilney,et al.  How individual cells develop from a syncytium: merogony in Theileria parva (Apicomplexa). , 1992, Journal of cell science.

[64]  D. Brown,et al.  Disruption of synchrony between parasite growth and host cell division is a determinant of differentiation to the merozoite in Theileria annulata. , 1992, Journal of cell science.

[65]  E. Soulsby Immune responses in parasitic infections: immunology, immunopathology, and immunoprophylaxis. Volume III: Protozoa. , 1987 .

[66]  W. Morrison,et al.  Immunopathology, immunology, and immunoprophylaxis of Theileria infections. , 1987 .

[67]  J. Devereux,et al.  A comprehensive set of sequence analysis programs for the VAX , 1984, Nucleic Acids Res..

[68]  C. Brown,et al.  Transition of Developmental Stages of Theileria parva in vitro at High Temperature , 1966, Nature.

[69]  L. Hulliger Cultivation of three species of Theileria in lymphoid cells in vitro. , 1965, The Journal of protozoology.