Highly Combinatorial Genetic Interaction Analysis Reveals a Multi-Drug Transporter Influence Network

[1]  Ben Lehner,et al.  Combinatorial Genetics Reveals a Scaling Law for the Effects of Mutations on Splicing , 2019, Cell.

[2]  Anthony M. Zador,et al.  Cellular barcoding: lineage tracing, screening and beyond , 2018, Nature Methods.

[3]  T. Ideker,et al.  Synthetic Lethal Networks for Precision Oncology: Promises and Pitfalls. , 2018, Journal of molecular biology.

[4]  Tom Ellis,et al.  Engineering a Model Cell for Rational Tuning of GPCR Signaling , 2018, Cell.

[5]  Neal K. Bennett,et al.  Mapping the Genetic Landscape of Human Cells , 2018, Cell.

[6]  D. Weinreich,et al.  Evolutionary constraints in fitness landscapes , 2018, Heredity.

[7]  Ben Lehner,et al.  Pairwise and higher order genetic interactions during the evolution of a tRNA , 2018, Nature.

[8]  Attila Balint,et al.  Systematic analysis of complex genetic interactions , 2018, Science.

[9]  Ben Lehner,et al.  The genetic landscape of a physical interaction , 2018, eLife.

[10]  Roded Sharan,et al.  Using deep learning to model the hierarchical structure and function of a cell , 2018, Nature Methods.

[11]  Michael T. McManus,et al.  Dual gene activation and knockout screen reveals directional dependencies in genetic networks , 2018, Nature Biotechnology.

[12]  Kendall R. Sanson,et al.  Orthologous CRISPR-Cas9 enzymes for Combinatorial Genetic Screens , 2017, Nature Biotechnology.

[13]  Grant W. Brown,et al.  Mapping DNA damage-dependent genetic interactions in yeast via orgy mating and barcode fusion genetics , 2017, bioRxiv.

[14]  Aaron N. Chang,et al.  Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions , 2017, Nature Methods.

[15]  B. Williams,et al.  Reconstructing a metazoan genetic pathway with transcriptome-wide epistasis measurements , 2017, Proceedings of the National Academy of Sciences.

[16]  Ramsey I Zeitoun,et al.  Quantitative Tracking of Combinatorially Engineered Populations with Multiplexed Binary Assemblies. , 2017, ACS synthetic biology.

[17]  Thomas M. Norman,et al.  Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens , 2016, Cell.

[18]  L. Cowen,et al.  Beauvericin Potentiates Azole Activity via Inhibition of Multidrug Efflux, Blocks Candida albicans Morphogenesis, and Is Effluxed via Yor1 and Circuitry Controlled by Zcf29 , 2016, Antimicrobial Agents and Chemotherapy.

[19]  Adam P. Rosebrock,et al.  A global genetic interaction network maps a wiring diagram of cellular function , 2016, Science.

[20]  Dmitry Chudakov,et al.  Local fitness landscape of the green fluorescent protein , 2016, Nature.

[21]  Yishi Jin,et al.  Targeted Mutagenesis of Duplicated Genes in Caenorhabditis elegans Using CRISPR-Cas9. , 2016, Journal of genetics and genomics = Yi chuan xue bao.

[22]  L. Kruglyak,et al.  CRISPR-directed mitotic recombination enables genetic mapping without crosses , 2016, Science.

[23]  Timothy K Lu,et al.  Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM , 2016, Proceedings of the National Academy of Sciences.

[24]  Jian‐Kang Zhu,et al.  A multiplex CRISPR/Cas9 platform for fast and efficient editing of multiple genes in Arabidopsis , 2015, Plant Cell Reports.

[25]  Nanette R Boyle,et al.  Multiplexed tracking of combinatorial genomic mutations in engineered cell populations , 2015, Nature Biotechnology.

[26]  Ida Bonde,et al.  Multiplex metabolic pathway engineering using CRISPR/Cas9 in Saccharomyces cerevisiae. , 2015, Metabolic engineering.

[27]  Matthew B. Taylor,et al.  Genetic Interactions Involving Five or More Genes Contribute to a Complex Trait in Yeast , 2014, PLoS genetics.

[28]  Gary D. Bader,et al.  Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures , 2014, Science.

[29]  Maitreya J. Dunham,et al.  Control of Plasma Membrane Permeability by ABC Transporters , 2014, Eukaryotic Cell.

[30]  Merja Penttilä,et al.  Yeast oligo-mediated genome engineering (YOGE). , 2013, ACS synthetic biology.

[31]  K. J. Henley,et al.  ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis. , 2013, Cell metabolism.

[32]  Susan R. Wente,et al.  Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system , 2013, Proceedings of the National Academy of Sciences.

[33]  Bryan-Joseph San Luis,et al.  Mapping the functional yeast ABC transporter interactome , 2013, Nature chemical biology.

[34]  Kerry Bloom,et al.  Systematic triple-mutant analysis uncovers functional connectivity between pathways involved in chromosome regulation. , 2013, Cell reports.

[35]  Rudolf Jaenisch,et al.  One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering , 2013, Cell.

[36]  L. Kruglyak,et al.  Finding the sources of missing heritability in a yeast cross , 2012, Nature.

[37]  Lan V. Zhang,et al.  Knocking out multi-gene redundancies via cycles of sexual assortment and fluorescence selection , 2010, Nature Methods.

[38]  J. Snider,et al.  Split-Ubiquitin Based Membrane Yeast Two-Hybrid (MYTH) System: A Powerful Tool For Identifying Protein-Protein Interactions , 2010, Journal of visualized experiments : JoVE.

[39]  Gary D Bader,et al.  The Genetic Landscape of a Cell , 2010, Science.

[40]  C. Paumi,et al.  ABC Transporters in Saccharomyces cerevisiae and Their Interactors: New Technology Advances the Biology of the ABCC (MRP) Subfamily , 2009, Microbiology and Molecular Biology Reviews.

[41]  Farren J. Isaacs,et al.  Programming cells by multiplex genome engineering and accelerated evolution , 2009, Nature.

[42]  D. G. Gibson,et al.  Enzymatic assembly of DNA molecules up to several hundred kilobases , 2009, Nature Methods.

[43]  Julie M. Sahalie,et al.  An experimentally derived confidence score for binary protein-protein interactions , 2008, Nature Methods.

[44]  C. Paumi,et al.  Negative Regulation of the Yeast ABC Transporter Ycf1p by Phosphorylation within Its N-terminal Extension* , 2008, Journal of Biological Chemistry.

[45]  C. Landry,et al.  An in Vivo Map of the Yeast Protein Interactome , 2008, Science.

[46]  A. Goffeau,et al.  Compensatory activation of the multidrug transporters Pdr5p, Snq2p, and Yor1p by Pdr1p in Saccharomyces cerevisiae , 2008, FEBS letters.

[47]  Robert P. St.Onge,et al.  Defining genetic interaction , 2008, Proceedings of the National Academy of Sciences.

[48]  F. Russel,et al.  The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane. , 2008, Kidney international.

[49]  Ronald W. Davis,et al.  Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions , 2007, Nature Genetics.

[50]  S. Yamanaka,et al.  Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors , 2006, Cell.

[51]  Jonathan C. Cohen,et al.  ABCG5 and ABCG8 Are Obligate Heterodimers for Protein Trafficking and Biliary Cholesterol Excretion* , 2003, Journal of Biological Chemistry.

[52]  Ronald W. Davis,et al.  Functional profiling of the Saccharomyces cerevisiae genome , 2002, Nature.

[53]  A. Goffeau,et al.  The Effects of Transcription Regulating Genes PDR1, pdr1-3 and PDR3 in Pleiotropic Drug Resistance , 2001, Proteomics.

[54]  D. Keppler,et al.  Up‐regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver , 2001, Hepatology.

[55]  J. Rine,et al.  Overlapping functions of the yeast oxysterol-binding protein homologues. , 2001, Genetics.

[56]  B. Garvik,et al.  Principles for the buffering of genetic variation. , 2001 .

[57]  C. Hollenberg,et al.  Concurrent knock‐out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae , 1999, FEBS letters.

[58]  D. Keppler,et al.  Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane , 1999, Hepatology.

[59]  R. Schiestl,et al.  High-efficiency yeast transformation using the LiAc/SS carrier DNA/PEG method , 2007, Nature Protocols.

[60]  Atina G. Coté,et al.  Pooled‐matrix protein interaction screens using Barcode Fusion Genetics , 2016, Molecular systems biology.