A Clinicopathological Study on Valvular Diseases in 3, 000 Consecutive Autopsyes of the Aged : SYMPOSIUM ON CURRENT PROBLEMS IN VALVULAR HEART DISEASE

The incidence and etiological classification of valvular diseases were examined on 358 cases from 3, 000 consecutive autopsyes of more than 60 years of age. The incidence of valvular disease was 11.9% (358 out of 3, 000 cases). Mitral stenosis was found in 23 cases (6.4%), of which 21 cases were rheumatic and the remaining 2 were mitral ring calcification (MRC). Mitral regurgitation was observed in 126 cases (35.3%): 69 of papillary muscle dysfunction, 26 of mitral valve prolapse (MVP), 16 of MRC, 9 of ruptured chordae tendineae, 3 of rheumatic and 3 of congenital. Aortic stenosis was noted in 33 cases (9.2%): 27 of calcified, 5 of rheumatic and one of congenital. Aortic regurgitation was found in 169 cases (47.2%): 112 of degenerative, 47 of syphilitic, 7 of rheumatic and 2 of aortitis syndrome. There were 6 cases ( 1.7%) of tricuspid regurgitation. Etiological classification revealed 6 cases (1.7%) of congenital, 36 (10%) of rheumatic, 49 (1 3.7%) of syphilitic, 27 (7.5%) of MVP, 69 (19.3%) of ischemic and 166 (46.4%) of degenerative valvular disease. The results emphasize the high incidence of non-inflammatory valvular diseases including those of degenerative etiology in the cases studied.

[1]  S. Matsushita,et al.  A clinicopathological study on valvular diseases in 1,000 consecutive autopsy of the aged. , 1981, Japanese heart journal.

[2]  K. Ueda,et al.  Clinicopathologic aspects of ischemic heart disease in the elderly. , 1981, Japanese heart journal.

[3]  K. Kuwako,et al.  A clinicopathological study on mitral ring calcification. , 1977, Japanese heart journal.

[4]  K. Ueda,et al.  A clinicopathological study on the papillary muscle dysfunction. , 1977, Japanese heart journal.

[5]  H. Shimada,et al.  A Clinicopathological Study on the Heart Diseases in the Aged , 1975 .

[6]  M. Davies,et al.  The Pathology of the heart , 1975 .

[7]  M. Sugiura,et al.  A clinicopathological study on the syphilitic aortic regurgitation in the aged. , 1973, Japanese Heart Journal.

[8]  W. Roberts,et al.  Mitral Valvular Disease: A Clinicopathologic Survey of the Conditions Causing the Mitral Valve To Function Abnormally , 1972 .

[9]  E D Wigle,et al.  Morphology of the Human Mitral Valve: I. Chordae Tendineae A New Classification , 1970, Circulation.

[10]  E D Wigle,et al.  Morphology of the Human Mitral Valve: II. The Valve Leaflets , 1970, Circulation.

[11]  H. Shimada,et al.  Clinicopathological Studies on Normality in the Aged Heart , 1969 .

[12]  H. Shimada,et al.  A new etiological concept of the aortic regurgitation in the aged. Prolapsed cusp due to degeneration. , 1969, Japanese Heart Journal.

[13]  G. Burch,et al.  The syndrome of papillary muscle dysfunction. , 1968, American heart journal.

[14]  E. Braunwald,et al.  Acute Severe Mitral Regurgitation Secondary to Ruptured Chordae Tendineae: Clinical, Hemodynamic, and Pathologic Considerations , 1966, Circulation.

[15]  R. Read,et al.  Symptomatic Valvular Myxomatous Transformation (The Floppy Valve Syndrome): A Possible Forme Fruste of the Marfan Syndrome , 1965, Circulation.

[16]  P. Marchand,et al.  The significance of late systolic murmurs , 1963 .

[17]  G. Burch,et al.  Clinical manifestations of papillary muscle dysfunction. , 1963, Archives of internal medicine.

[18]  R. Desanctis,et al.  Massive calcification of the mitral annulus. A clinicopathological study of fourteen cases. , 1962, The New England journal of medicine.

[19]  H. Hellerstein,et al.  The incidence of heart disease in 2,000 consecutive autopsies. , 1948, Annals of internal medicine.