Perisylvian white matter connectivity in the human right hemisphere

BackgroundBy using diffusion tensor magnetic resonance imaging (DTI) and subsequent tractography, a perisylvian language network in the human left hemisphere recently has been identified connecting Brocas's and Wernicke's areas directly (arcuate fasciculus) and indirectly by a pathway through the inferior parietal cortex.ResultsApplying DTI tractography in the present study, we found a similar three-way pathway in the right hemisphere of 12 healthy individuals: a direct connection between the superior temporal and lateral frontal cortex running in parallel with an indirect connection. The latter composed of a posterior segment connecting the superior temporal with the inferior parietal cortex and an anterior segment running from the inferior parietal to the lateral frontal cortex.ConclusionThe present DTI findings suggest that the perisylvian inferior parietal, superior temporal, and lateral frontal corticies are tightly connected not only in the human left but also in the human right hemisphere.

[1]  J. Tsuruda,et al.  Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system. , 1990, Radiology.

[2]  C. Büchel,et al.  White matter asymmetry in the human brain: a diffusion tensor MRI study. , 2004, Cerebral cortex.

[3]  Aad van der Lugt,et al.  Fiber density asymmetry of the arcuate fasciculus in relation to functional hemispheric language lateralization in both right- and left-handed healthy subjects: A combined fMRI and DTI study , 2007, NeuroImage.

[4]  P. Basser,et al.  In vivo fiber tractography using DT‐MRI data , 2000, Magnetic resonance in medicine.

[5]  Karl Friedrich Burdach Vom Baue und Leben des gehirns , 1819 .

[6]  Derek K. Jones,et al.  Perisylvian language networks of the human brain , 2005, Annals of neurology.

[7]  Denis Le Bihan,et al.  Imagerie de diffusion in-vivo par résonance magnétique nucléaire , 1985 .

[8]  A. Kertesz Localization in neuropsychology , 1983 .

[9]  M. Raichle,et al.  Tracking neuronal fiber pathways in the living human brain. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[10]  D. Pandya,et al.  Segmentation of subcomponents within the superior longitudinal fascicle in humans: a quantitative, in vivo, DT-MRI study. , 2005, Cerebral cortex.

[11]  J. Driver,et al.  Task-related modulation of visual neglect in cancellation tasks , 2009, Neuropsychologia.

[12]  P. Basser,et al.  MR diffusion tensor spectroscopy and imaging. , 1994, Biophysical journal.

[13]  Umberto Sabatini,et al.  Neural bases of personal and extrapersonal neglect in humans. , 2007, Brain : a journal of neurology.

[14]  S C Williams,et al.  Non‐invasive assessment of axonal fiber connectivity in the human brain via diffusion tensor MRI , 1999, Magnetic resonance in medicine.

[15]  Katrin Amunts,et al.  White matter fiber tracts of the human brain: Three-dimensional mapping at microscopic resolution, topography and intersubject variability , 2006, NeuroImage.

[16]  Dae-Shik Kim,et al.  Diffusion tensor spectroscopy and imaging of the arcuate fasciculus , 2008, NeuroImage.

[17]  D. Pandya,et al.  Association fibre pathways of the brain: parallel observations from diffusion spectrum imaging and autoradiography. , 2007, Brain : a journal of neurology.

[18]  P. V. van Zijl,et al.  Three‐dimensional tracking of axonal projections in the brain by magnetic resonance imaging , 1999, Annals of neurology.

[19]  Chris Rorden,et al.  The anatomy of spatial neglect based on voxelwise statistical analysis: a study of 140 patients. , 2004, Cerebral cortex.

[20]  Derek K. Jones,et al.  Symmetries in human brain language pathways correlate with verbal recall , 2007, Proceedings of the National Academy of Sciences.

[21]  J. Dejerine Anatomie des centres nerveux , 1895 .

[22]  C. Kennard,et al.  The anatomy of visual neglect. , 2003, Brain : a journal of neurology.

[23]  S. Ferber,et al.  Spatial awareness is a function of the temporal not the posterior parietal lobe , 2001, Nature.

[24]  D. Perani,et al.  The anatomy of unilateral neglect after right-hemisphere stroke lesions. A clinical/CT-scan correlation study in man , 1986, Neuropsychologia.