Paeonol derivative-6 attenuates inflammation by activating ZEB2 in acute liver injury.

[1]  Lianghui Zhan,et al.  Dendrobium officinale polysaccharides protected against ethanol-induced acute liver injury in vivo and in vitro via the TLR4/NF-κB signaling pathway. , 2020, Cytokine.

[2]  M. Lucena,et al.  Differential hepatoprotective role of the cannabinoid CB1 and CB2 receptors in paracetamol‐induced liver injury , 2020, British journal of pharmacology.

[3]  E. O'Duibhir,et al.  Alternatively activated macrophages promote resolution of necrosis following acute liver injury , 2020, Journal of hepatology.

[4]  Yang Sheng Hu,et al.  Novel paeonol derivatives: Design, synthesis and anti-inflammatory activity in vitro and in vivo. , 2020, Bioorganic chemistry.

[5]  Daqiang Wu,et al.  Paeonol ameliorates murine alcohol liver disease via mycobiota‐mediated Dectin‐1/IL‐1β signaling pathway , 2020, Journal of leukocyte biology.

[6]  Peng-Fei Yi,et al.  Anti-inflammatory and antioxidative properties of helicid protect against CCl4 induced acute liver injury in mice , 2020, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

[7]  Jie Feng,et al.  Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl4-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling , 2020, Pharmaceutical Biology.

[8]  Bing Zhang,et al.  Inhibition Of JNK Phosphorylation By Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury , 2019, Drug design, development and therapy.

[9]  Peng Ye,et al.  Paeonol attenuates inflammation by targeting HMGB1 through upregulating miR-339-5p , 2019, Scientific Reports.

[10]  Yu Zhang,et al.  miR-498 inhibits the growth and metastasis of liver cancer by targeting ZEB2 , 2018, Oncology reports.

[11]  Cheng Huang,et al.  MicroRNA‐145 induces the senescence of activated hepatic stellate cells through the activation of p53 pathway by ZEB2 , 2018, Journal of cellular physiology.

[12]  Chan-Min Liu,et al.  Role of AMPK pathway in lead-induced endoplasmic reticulum stress in kidney and in paeonol-induced protection in mice. , 2018, Food and Chemical Toxicology.

[13]  U. Sohn,et al.  Humulus japonicus Extracts Protect Against Lipopolysaccharide/d-Galactosamine-Induced Acute Liver Injury in Rats. , 2018, Journal of medicinal food.

[14]  Yu-jie Fu,et al.  Paeonol alleviated acute alcohol-induced liver injury via SIRT1/Nrf2/NF-κB signaling pathway. , 2018, Environmental toxicology and pharmacology.

[15]  Lei Yu,et al.  Maslinic acid protects against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice. , 2018, Microbial pathogenesis.

[16]  Cheng Huang,et al.  MicroRNA-145 Increases the Apoptosis of Activated Hepatic Stellate Cells Induced by TRAIL through NF-κB Signaling Pathway , 2018, Front. Pharmacol..

[17]  Lei Dong,et al.  Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury , 2018, International immunopharmacology.

[18]  Yang Wang,et al.  ZEB2 Attenuates LPS-Induced Inflammation by the NF-κB Pathway in HK-2 Cells , 2018, Inflammation.

[19]  Chenggui Wang,et al.  Paeonol Inhibits IL-1β-Induced Inflammation via PI3K/Akt/NF-κB Pathways: In Vivo and Vitro Studies , 2017, Inflammation.

[20]  Zi-heng Wu,et al.  Zinc Finger E-Box Binding Protein 2 (ZEB2) Suppress Apoptosis of Vascular Endothelial Cells Induced by High Glucose Through Mitogen-Activated Protein Kinases (MAPK) Pathway Activation , 2017, Medical science monitor : international medical journal of experimental and clinical research.

[21]  J. Wan,et al.  Glycyrrhetinic acid attenuates lipopolysaccharide‐induced fulminant hepatic failure in d‐galactosamine‐sensitized mice by up‐regulating expression of interleukin‐1 receptor‐associated kinase‐M , 2017, Toxicology and applied pharmacology.

[22]  Weining Lu,et al.  Loss of Zeb2 in mesenchyme-derived nephrons causes primary glomerulocystic disease. , 2016, Kidney international.

[23]  P. Kubes,et al.  Innate Immune Cell Trafficking and Function During Sterile Inflammation of the Liver. , 2016, Gastroenterology.

[24]  N. McGovern,et al.  Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species , 2016, Immunity.

[25]  K. Choy,et al.  Paeonol protects against endoplasmic reticulum stress-induced endothelial dysfunction via AMPK/PPARδ signaling pathway. , 2016, Biochemical pharmacology.

[26]  J. Kotoky,et al.  Protective Effect of Bioactivity Guided Fractions of Ziziphus jujuba Mill. Root Bark against Hepatic Injury and Chronic Inflammation via Inhibiting Inflammatory Markers and Oxidative Stress , 2016, Front. Pharmacol..

[27]  Ping Zhang,et al.  Biochanin A protects lipopolysaccharide/D-galactosamine-induced acute liver injury in mice by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation. , 2016, International immunopharmacology.

[28]  M. Brehm,et al.  Inflammation Mediated by JNK in Myeloid Cells Promotes the Development of Hepatitis and Hepatocellular Carcinoma. , 2016, Cell reports.

[29]  A. Caccuri,et al.  c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition , 2016, Journal of Translational Medicine.

[30]  Ke Chen,et al.  LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression by sponging miR-200s in clear cell kidney carcinoma , 2015, Oncotarget.

[31]  F. Qiu,et al.  Anti-inflammatory and Anti-oxidative Activities of Paeonol and Its Metabolites Through Blocking MAPK/ERK/p38 Signaling Pathway , 2015, Inflammation.

[32]  G. O’Keeffe,et al.  Zeb2: A multifunctional regulator of nervous system development , 2015, Progress in Neurobiology.

[33]  H. Kim,et al.  Hepatoprotective Effect of Terminalia chebula against t-BHP-Induced Acute Liver Injury in C57/BL6 Mice , 2015, Evidence-based complementary and alternative medicine : eCAM.

[34]  G. Berx,et al.  ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling , 2015, Nature Communications.

[35]  Z. Lu,et al.  C-Jun N-terminal kinases are required for oncolytic adenovirus-mediated autophagy , 2014, Oncogene.

[36]  Tzong-Shyuan Lee,et al.  Paeonol Attenuates Cigarette Smoke-Induced Lung Inflammation by Inhibiting ROS-Sensitive Inflammatory Signaling , 2014, Mediators of inflammation.

[37]  Haihua Feng,et al.  Paeonol suppresses lipopolysaccharide‐induced inflammatory cytokines in macrophage cells and protects mice from lethal endotoxin shock , 2014, Fundamental & clinical pharmacology.

[38]  E. V. Van Bockstaele,et al.  Suppression of MAPK/JNK-MTORC1 signaling leads to premature loss of organelles and nuclei by autophagy during terminal differentiation of lens fiber cells , 2014, Autophagy.

[39]  H. Bae,et al.  Paeonol, a Major Compound of Moutan Cortex, Attenuates Cisplatin-Induced Nephrotoxicity in Mice , 2013, Evidence-based complementary and alternative medicine : eCAM.

[40]  H. Soininen,et al.  Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome , 2013, Progress in Neurobiology.

[41]  J. Wendon,et al.  Acute liver failure. , 2013, The New England journal of medicine.

[42]  Jürgen Popp,et al.  Liver Dysfunction and Phosphatidylinositol-3-Kinase Signalling in Early Sepsis: Experimental Studies in Rodent Models of Peritonitis , 2012, PLoS medicine.

[43]  D. Huylebroeck,et al.  Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo. , 2011, Cytokine & growth factor reviews.

[44]  Zhaoli Sun,et al.  Interleukin‐6 is an important mediator for mitochondrial DNA repair after alcoholic liver injury in mice , 2010, Hepatology.

[45]  J. Magarian Blander,et al.  Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function , 2010, The Journal of experimental medicine.

[46]  K. Krause,et al.  NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice. , 2009, American journal of respiratory and critical care medicine.

[47]  M. Katoh,et al.  Integrative genomic analyses of ZEB2: Transcriptional regulation of ZEB2 based on SMADs, ETS1, HIF1α, POU/OCT, and NF-κB , 2009 .

[48]  M. Harboe,et al.  Innate Immune Responses to Danger Signals in Systemic Inflammatory Response Syndrome and Sepsis , 2009, Scandinavian journal of immunology.

[49]  H. Spapen.  Liver Perfusion in Sepsis, Septic Shock, and Multiorgan Failure , 2008, Anatomical record.

[50]  A. Murakami,et al.  Targeting NOX, INOS and COX‐2 in inflammatory cells: Chemoprevention using food phytochemicals , 2007, International journal of cancer.

[51]  R. Milanino,et al.  Copper: Role of the 'Endogenous' and 'Exogenous' Metal on the Development and Control of Inflammatory Processes , 2006, Reviews on environmental health.

[52]  R. Davis,et al.  Signal Transduction by the JNK Group of MAP Kinases , 2000, Cell.

[53]  M. Luster,et al.  Essential role of tumor necrosis factor α in alcohol-induced liver injury in mice , 1999 .

[54]  L. Nelles,et al.  SIP1, a Novel Zinc Finger/Homeodomain Repressor, Interacts with Smad Proteins and Binds to 5′-CACCT Sequences in Candidate Target Genes* , 1999, The Journal of Biological Chemistry.

[55]  C. McClain,et al.  Cytokines in Alcoholic Liver Disease , 1999, Seminars in liver disease.

[56]  C. McClain,et al.  Tumor necrosis factor in alcohol enhanced endotoxin liver injury. , 1992, Alcoholism, clinical and experimental research.