Decreased secretory immunoglobulins following intense endurance exercise

The high frequency of recurrent respiratory infections following “overtraining”; in competitive athletes prompted this study to examine the effects of severe exercise on the mucosal immune response. A previous study from this laboratory demonstrated decreased salivary IgA levels after a 50‐km national Nordic ski competition. To further elucidate the specific role of exercise rather than environmental conditions (e.g., cold), we studied competitive bicyclists under controlled laboratory conditions. Eight male bicyclists exercised at 70‐75 percent of VO2 max for two hours, and parotid saliva was collected immediately before and after, and 1,24 and 48 hours after exercise. Both salivary IgA and IgM levels decreased immediately after exercise (63 and 44 percent decreases, respectively), remained low for one hour, and returned to pre‐exercise levels by 24 hours after exercise. Salivary IgG, serum IgA, IgG, and IgM levels, and serum antibodies to specific antigens were not changed after exercise, indicating a s...

[1]  F. Liew,et al.  Cross‐protection in mice infected with influenza A virus by the respiratory route is correlated with local IgA antibody rather than serum antibody or cytotoxic T cell reactivity , 1984, European journal of immunology.

[2]  M. Conley,et al.  Production of predominantly polymeric IgA by human peripheral blood lymphocytes stimulated in vitro with mitogens , 1980, The Journal of experimental medicine.

[3]  I. Mills,et al.  Opiate receptors on lymphocytes and platelets in man. , 1983, Clinical immunology and immunopathology.

[4]  H. Aarstad,et al.  Stress Causes Reduced Natural Killer Activity in Mice , 1983, Scandinavian journal of immunology.

[5]  R. Chanock,et al.  Secretory and systemic immunological response in children infected with live attenuated influenza A virus vaccines , 1982, Infection and immunity.

[6]  E. Tan,et al.  CHARACTERISTICS OF AN IMMUNE SYSTEM COMMON TO CERTAIN EXTERNAL SECRETIONS , 1965, The Journal of experimental medicine.

[7]  F. Tristani,et al.  Running Elevates Plasma β-Endorphin Immunoreactivity and ACTH in Untrained Human Subjects , 1981, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[8]  T. Tomasi,et al.  Humoral aspects of mucosal immunity , 1985 .

[9]  T. Appelboom,et al.  Suggestive evidence for receptors for morphine and methionine-enkephalin on normal human blood T lymphocytes. , 1979, Journal of immunology.

[10]  W. Morgan,et al.  Increases in plasma beta-endorphin/beta-lipotropin immunoreactivity after treadmill running in humans. , 1982, Journal of applied physiology: respiratory, environmental and exercise physiology.

[11]  J. C. Perkins,et al.  Comparison of protective effect of neutralizing antibody in serum and nasal secretions in experimental rhinovirus type 13 illness. , 1969, American journal of epidemiology.

[12]  Herbert Benson,et al.  ACADEMIC STRESS, POWER MOTIVATION, AND DECREASE IN SECRETION RATE OF SALIVARY SECRETORY IMMUNOGLOBULIN A , 1983, The Lancet.

[13]  M. Zykov,et al.  Study of secretory and antiviral immunity in sportsmen , 1988 .

[14]  J. Mcghee,et al.  Selective induction of an immune response in human external secretions by ingestion of bacterial antigen. , 1978, The Journal of clinical investigation.

[15]  M. Mcgregor,et al.  BIOSTATISTICS IN CLINICAL MEDICINE. , 1987 .

[16]  R. Douglas,et al.  The role of nasal secretion and serum antibody in the rhinovirus common cold. , 1966, American journal of epidemiology.

[17]  Y. Shavit,et al.  Opioid peptides mediate the suppressive effect of stress on natural killer cell cytotoxicity. , 1984, Science.

[18]  P. Brandtzaeg.  Human secretory immunoglobulins. II. Salivary secretions from individuals with selectively excessive or defective synthesis of serum immunoglobulins. , 1971, Clinical and experimental immunology.

[19]  E. Bateman,et al.  Ultramarathon running and upper respiratory tract infections. An epidemiological survey. , 1983, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

[20]  F. Massey,et al.  Introduction to Statistical Analysis , 1970 .

[21]  S. Avrameas,et al.  Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. , 1969, Immunochemistry.

[22]  R. Williams,et al.  Inhibition of Bacterial Adherence by Secretory Immunoglobulin A: A Mechanism of Antigen Disposal , 1972, Science.

[23]  R. Purcell,et al.  Protective effect of antibody to parainfluenza type 1 virus. , 1966, The New England journal of medicine.

[24]  H. Peeters.  Protides of the Biological Fluids , 1958 .

[25]  S. Schleifer,et al.  Suppression of lymphocyte stimulation following bereavement. , 1983, JAMA.

[26]  Y. Shavit,et al.  Apparent involvement of opioid peptides in stress-induced enhancement of tumor growth , 1983, Peptides.

[27]  G. Delespesse,et al.  Distribution of beta-adrenergic receptors on human lymphocyte subpopulations. , 1979, Clinical and experimental immunology.