论文信息 - Imaging of cortical haemoglobin concentration with RGB reflectometry

Imaging of cortical haemoglobin concentration with RGB reflectometry

We demonstrate that a colour RGB-CCD camera can be used to map haemoglobin changes of the exposed cortex following cortical activation and spreading depression in rats. We examine its performance by a comparison with narrow bandpass spectroscopy and evaluation of the extinction spectra of haemoglobin based on condition number analysis.

[1] I. Nishidate,et al. Visualizing of skin chromophore concentrations by use of RGB images. , 2008, Optics letters.

[2] U Dirnagl,et al. Nitric oxide: a modulator, but not a mediator, of neurovascular coupling in rat somatosensory cortex. , 1999, The American journal of physiology.

[3] Elizabeth M C Hillman,et al. Optical brain imaging in vivo: techniques and applications from animal to man. , 2007, Journal of biomedical optics.

[4] A. Villringer,et al. Physical model for the spectroscopic analysis of cortical intrinsic optical signals. , 2000, Physics in medicine and biology.

[5] A. Grinvald,et al. Interactions Between Electrical Activity and Cortical Microcirculation Revealed by Imaging Spectroscopy: Implications for Functional Brain Mapping , 1996, Science.

[6] A. Villringer,et al. Non-invasive optical spectroscopy and imaging of human brain function , 1997, Trends in Neurosciences.

[7] A Villringer,et al. Separation of changes in light scattering and chromophore concentrations during cortical spreading depression in rats. , 1998, Optics letters.