论文信息 - T helper cell type 1 (Th1)- and Th2-like responses are present in mice with gastric candidiasis but protective immunity is associated with Th1 development.

T helper cell type 1 (Th1)- and Th2-like responses are present in mice with gastric candidiasis but protective immunity is associated with Th1 development.

The relative contributions of local T helper cell type 1 (Th1)- and Th2-like responses to the course of primary and secondary gastrointestinal (GI) candidiasis were examined in adult immunocompetent BALB/c mice. Both Th1 cytokines, such as interferon-gamma (IFN-gamma), and the Th2 cytokines, interleukin (IL)-4 and IL-5, were produced by CD4+ cells from Peyer's patches (PP) and mesenteric lymph nodes at a time when the fungus was cleared from the stomach and intestine. Augmentation of antigen-specific Th2-like responses by treatment with cholera toxin did not modify the course of disease. In contrast, treatment with soluble IL-4 receptor, which increased Th1 cells, was associated with enhanced yeast clearance. In addition, IFN-gamma but not IL-4 mRNA was present in PP and spleen CD4+ cells in mice resistant to subsequent GI inoculation. Activation of Th1- but not Th2-like responses may be responsible locally for controlling GI candidiasis and generating protective immunity.

[1] F. Finkelman,et al. IFN inhibits inflammatory responses and protective immunity in mice infected with the nematode parasite, Nippostrongylus brasiliensis. , 1993, Journal of immunology.

[2] G. Cole,et al. Gastrointestinal and systemic candidosis in immunocompromised mice. , 1989, Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology.

[3] P. Puccetti,et al. Interleukin‐4 and interleukin‐10 inhibit nitric oxide‐dependent macrophage killing of Candida albicans , 1993, European journal of immunology.

[4] F. Urbani,et al. Cytokine gene expression in human peripheral blood mononuclear cells stimulated by mannoprotein constituents from Candida albicans , 1993, Infection and immunity.

[5] P. Puccetti,et al. CD4+ subset expression in murine candidiasis. Th responses correlate directly with genetically determined susceptibility or vaccine-induced resistance. , 1993, Journal of immunology.

[6] C. Pankhurst,et al. REDUCED CD4+ T CELLS AND SEVERE ORAL CANDIDIASIS IN ABSENCE OF HIV INFECTION , 1989, The Lancet.

[7] R. Coffman,et al. Regulation of immunity to parasites by T cells and T cell-derived cytokines. , 1992, Annual review of immunology.

[8] T. deVos,et al. A rapid method to determine the isotype and specificity of coproantibodies in mice infected with Trichinella or fed cholera toxin. , 1991, Journal of immunological methods.

[9] G. Friedland,et al. Oral candidiasis in high-risk patients as the initial manifestation of the acquired immunodeficiency syndrome. , 1984, The New England journal of medicine.

[10] A. Sher,et al. Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni , 1991, The Journal of experimental medicine.

[11] J. Mcghee,et al. Selective induction of Th2 cells in murine Peyer's patches by oral immunization. , 1992, International immunology.

[12] G. D. Miralles,et al. Th1 and Th2 cell-associated cytokines in experimental visceral leishmaniasis , 1994, Infection and immunity.

[13] J. Sobel,et al. Effects of preinduced Candida-specific systemic cell-mediated immunity on experimental vaginal candidiasis , 1994, Infection and immunity.

[14] E. Balish,et al. Mucosal and disseminated candidiasis in gnotobiotic SCID mice. , 1993, Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology.

[15] C. Palma,et al. Proliferative and cytotoxic responses to mannoproteins of Candida albicans by peripheral blood lymphocytes of HIV‐infected subjects , 1991, Clinical and experimental immunology.

[16] P. Puccetti,et al. Mucosal and systemic T helper cell function after intragastric colonization of adult mice with Candida albicans. , 1993, The Journal of infectious diseases.

[17] R. Hector,et al. Enhanced immune responses in mice treated with penicillin-tetracycline or trimethoprim-sulfamethoxazole when colonized intragastrically with Candida albicans , 1987, Antimicrobial Agents and Chemotherapy.

[18] J. Mcghee,et al. alpha beta T cell receptor-positive intraepithelial lymphocytes with CD4+, CD8- and CD4+, CD8+ phenotypes from orally immunized mice provide Th2-like function for B cell responses. , 1993, Journal of immunology.

[19] P. Puccetti,et al. Natural killer cells do not play a dominant role in CD4+ subset differentiation in Candida albicans-infected mice , 1993, Infection and immunity.

[20] A. Sher,et al. Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology , 1994, The Journal of experimental medicine.

[21] K. Squires,et al. Acquired resistance and granuloma formation in experimental visceral leishmaniasis. Differential T cell and lymphokine roles in initial versus established immunity. , 1992, Journal of immunology.

[22] H. Weiner,et al. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. , 1994, Science.

[23] U. Grohmann,et al. Neutralization of IL-10 up-regulates nitric oxide production and protects susceptible mice from challenge with Candida albicans. , 1994, Journal of immunology.

[24] F. Finkelman,et al. Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites , 1994, The Journal of experimental medicine.

[25] W. Paul,et al. Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[26] F. Odds,et al. Candida and candidosis , 1979 .