CFD analysis of interphase mass transfer and energy dissipation in a milliliter-scale stirred-tank reactor for filamentous microorganisms

[1]  D. Weuster‐Botz,et al.  Process performance of parallel bioreactors for batch cultivation of Streptomyces tendae , 2011, Bioprocess and biosystems engineering.

[2]  D. Weuster‐Botz,et al.  Reaction engineering studies for the production of 2-hydroxyisobutyric acid with recombinant Cupriavidus necator H 16 , 2010, Applied Microbiology and Biotechnology.

[3]  Dirk Weuster-Botz,et al.  New milliliter‐scale stirred tank bioreactors for the cultivation of mycelium forming microorganisms , 2010, Biotechnology and bioengineering.

[4]  Alvin W. Nienow.  Stirred Tank Reactors , 2010 .

[5]  Dirk Weuster-Botz,et al.  Milliliter-scale stirred tank reactors for the cultivation of microorganisms. , 2010, Advances in applied microbiology.

[6]  Florian R. Menter,et al.  Review of the shear-stress transport turbulence model experience from an industrial perspective , 2009 .

[7]  Dirk Weuster-Botz,et al.  Discrimination of riboflavin producing Bacillus subtilis strains based on their fed-batch process performances on a millilitre scale , 2009, Applied Microbiology and Biotechnology.

[8]  Tron Solberg,et al.  Flow Generated by an Aerated Rushton Impeller: Two‐phase PIV Experiments and Numerical Simulations , 2008 .

[9]  Christian Krause,et al.  Fully automated single-use stirred-tank bioreactors for parallel microbial cultivations , 2008, Bioprocess and biosystems engineering.

[10]  Andreas Liese,et al.  Biocatalytic ketone reduction—a powerful tool for the production of chiral alcohols—part II: whole-cell reductions , 2007, Applied Microbiology and Biotechnology.

[11]  Dirk Weuster-Botz,et al.  Scale-down and parallel operation of the riboflavin production process with Bacillus subtilis , 2007 .

[12]  Alain Liné,et al.  Modeling of oxygen mass transfer in a gas–liquid airlift reactor , 2007 .

[13]  Ville Alopaeus,et al.  Modelling Local Gas–Liquid Mass Transfer in Agitated Vessels , 2007 .

[14]  Pasi Moilanen,et al.  Modeling Aerated Fermenters with Computational Fluid Dynamics , 2006 .

[15]  Y. Chisti,et al.  Shear rate in stirred tank and bubble column bioreactors , 2006 .

[16]  Kevin J. Roberts,et al.  Modeling Turbulent Flows with Free-Surface in Unbaffled Agitated Vessels , 2006 .

[17]  Ville Alopaeus,et al.  Validation of bubble breakage, coalescence and mass transfer models for gas–liquid dispersion in agitated vessel , 2006 .

[18]  Dirk Weuster-Botz,et al.  Miniature bioreactors for automated high‐throughput bioprocess design (HTBD): reproducibility of parallel fed‐batch cultivations with Escherichia coli , 2005, Biotechnology and applied biochemistry.

[19]  Jyeshtharaj B. Joshi,et al.  Effect of Internals on the Flow Pattern and Mixing in Stirred Tanks , 2005 .

[20]  Dirk Weuster-Botz,et al.  Methods and milliliter scale devices for high-throughput bioprocess design , 2005, Bioprocess and biosystems engineering.

[21]  Peter L Bergquist,et al.  Heterologous protein expression in filamentous fungi. , 2005, Trends in biotechnology.

[22]  Alberto Brucato,et al.  Large-eddy simulation of turbulent flow in an unbaffled stirred tank driven by a Rushton turbine , 2005 .

[23]  Sakayu Shimizu,et al.  Whole organism biocatalysis. , 2005, Current opinion in chemical biology.

[24]  D Weuster-Botz,et al.  Development, parallelization, and automation of a gas-inducing milliliter-scale bioreactor for high-throughput bioprocess design (HTBD). , 2005, Biotechnology and bioengineering.

[25]  Jorge M. T. Vasconcelos,et al.  Gas-liquid mass transfer coefficient in stirred tanks interpreted through bubble contamination kinetics , 2004 .

[26]  M. Zlokarnik.  Scale-up from Mini Plants , 2004 .

[27]  António Joaquim Serralheiro,et al.  Bubble size in aerated stirred tanks , 2002 .

[28]  Sreenivas Jayanti,et al.  CFD Study of Power and Mixing Time for Paddle Mixing in Unbaffled Vessels , 2002 .

[29]  Geoffrey M. Evans,et al.  Predicting gas–liquid flow in a mechanically stirred tank , 2002 .

[30]  Catherine Xuereb,et al.  Influence of Gas Flow Rate on the Structure of Trailing Vortices of a Rushton Turbine: PIV Measurements and CFD Simulations , 2001 .

[31]  M. Watve,et al.  How many antibiotics are produced by the genus Streptomyces? , 2001, Archives of Microbiology.

[32]  W. Schmidell,et al.  Volumetric oxygen transfer coefficients (kLa) in batch cultivations involving non-Newtonian broths , 2001 .

[33]  M. Pazouki,et al.  Understanding the morphology of fungi , 2000 .

[34]  Vivek V. Ranade,et al.  Gas–liquid flow in stirred reactors: Trailing vortices and gas accumulation behind impeller blades , 1999 .

[35]  Alberto Brucato,et al.  Numerical prediction of flow fields in baffled stirred vessels: A comparison of alternative modelling approaches , 1998 .

[36]  Patrick J. Roache,et al.  Verification and Validation in Computational Science and Engineering , 1998 .

[37]  Ivan Fort,et al.  Velocity profiles in a closed, unbaffled vessel: comparison between experimental LDV data and numerical CFD predictions , 1997 .

[38]  Alberto Brucato,et al.  Turbulent flow in closed and free-surface unbaffled tanks stirred by radial impellers , 1996 .

[39]  M. Roustan,et al.  Numerical computation of turbulent gas-liquid dispersion in mechanically agitated vessels , 1996 .

[40]  Joel H. Ferziger,et al.  Computational methods for fluid dynamics , 1996 .

[41]  Weeratunge Malalasekera,et al.  An introduction to computational fluid dynamics - the finite volume method , 2007 .

[42]  A. Bakker,et al.  A COMPUTATIONAL MODEL FOR THE GAS-LIQUID FLOW IN STIRRED REACTORS , 1994 .

[43]  T. A. Engh,et al.  Flow induced by an impeller in an unbaffled tank—II. Numerical modelling , 1994 .

[44]  M. Moo-young,et al.  Liquid‐Phase mass transfer coefficients in bioreactors , 1992, Biotechnology and bioengineering.

[45]  M. Lilly,et al.  The effect of agitation on the morphology and penicillin production of Penicillium chrysogenum , 1990, Biotechnology and bioengineering.

[46]  C. W. Hirt,et al.  Volume of fluid (VOF) method for the dynamics of free boundaries , 1981 .

[47]  Donald S. Scott,et al.  An eddy cell model of mass transfer into the surface of a turbulent liquid , 1970 .

[48]  D'Ans,et al.  Taschenbuch für Chemiker und Physiker , 1943 .

[49]  L. Richardson,et al.  The Deferred Approach to the Limit. Part I. Single Lattice. Part II. Interpenetrating Lattices , 1927 .