NEUROVASCULAR UNIT DYSFUNCTION: A VASCULAR COMPONENT OF ALZHEIMER DISEASE?

I read the article by Bennaroch on neurovascular unit dysfunction being implicated in the pathogenesis of Alzheimer disease (AD) with interest, especially since it may be an early event in the development of AD.1 Dysregulation of the neurovascular unit could lead to increased levels of abeta forms, and abeta may in fact lead to such dysregulation. Abeta treated neuroblastoma cells show a dose dependent decrease in nitric oxide release, while morphine …