Conductive hydrogels: mechanically robust hybrids for use as biomaterials.

A hybrid system for producing conducting polymers within a doping hydrogel mesh is presented. These conductive hydrogels demonstrate comparable electroactivity to conventional conducting polymers without requiring the need for mobile doping ions which are typically used in literature. These hybrids have superior mechanical stability and a modulus significantly closer to neural tissue than materials which are commonly used for medical electrodes. Additionally they are shown to support the attachment and differentiation of neural like cells, with improved interaction when compared to homogeneous hydrogels. The system provides flexibility such that biologic incorporation can be tailored for application.

[1]  P. Sheng,et al.  Characterizing and Patterning of PDMS‐Based Conducting Composites , 2007 .

[2]  Nigel H Lovell,et al.  Cell attachment functionality of bioactive conducting polymers for neural interfaces. , 2009, Biomaterials.

[3]  L. Toppare,et al.  Conducting polymer composites: Polypyrrole and poly(vinyl chloride‐vinyl acetate) copolymer , 1997 .

[4]  K. Anseth,et al.  Attachment of fibronectin to poly(vinyl alcohol) hydrogels promotes NIH3T3 cell adhesion, proliferation, and migration. , 2001, Journal of biomedical materials research.

[5]  R. Bellamkonda,et al.  Stabilizing electrode-host interfaces: a tissue engineering approach. , 2001, Journal of rehabilitation research and development.

[6]  M. Abidian,et al.  Conducting‐Polymer Nanotubes for Controlled Drug Release , 2006, Advanced materials.

[7]  A. Guiseppi-Elie,et al.  Polypyrrole-hydrogel composites for the construction of clinically important biosensors. , 2002, Biosensors & bioelectronics.

[8]  Lim Mei Yee,et al.  Polypyrrole-polyethylene glycol conducting polymer composite films : Preparation and characterization , 2007 .

[9]  Nigel H Lovell,et al.  Impact of co-incorporating laminin peptide dopants and neurotrophic growth factors on conducting polymer properties. , 2010, Acta biomaterialia.

[10]  Saunders,et al.  Microgel Particles as a Matrix for Polymerization: A Study of Poly(N-isopropylacrylamide)-Poly(N-methylpyrrole) Dispersions. , 2000, Journal of colloid and interface science.

[11]  Ping Chen,et al.  Effects of poly(ethylene glycol) on electrical conductivity of poly(3,4-ethylenedioxythiophene)–poly(styrenesulfonic acid) film , 2005 .

[12]  Kristi S. Anseth,et al.  Characterization of hydrogels formed from acrylate modified poly(vinyl alcohol) macromers , 2000 .

[13]  K. Davidson,et al.  Synthesis of cross-linked electrically conductive polymers , 1999 .

[14]  B. D. Malhotra Defects in conducting polymers , 1988 .

[15]  C. Macosko,et al.  Electrochemical Processing of Conducting Polymer Fibers , 1993, Science.

[16]  Robert S. Loewe,et al.  Regioregular, Head-to-Tail Coupled Poly(3-alkylthiophenes) Made Easy by the GRIM Method: Investigation of the Reaction and the Origin of Regioselectivity , 2001 .

[17]  Thomas Stieglitz,et al.  On the stability of poly-ethylenedioxythiopene as coating material for active neural implants. , 2011, Artificial organs.

[18]  C. Erkey,et al.  Synthesis of Conductive Elastomeric Foams by an In Situ Polymerization of Pyrrole Using Supercritical Carbon Dioxide and Ethanol Cosolvents , 2001 .

[19]  Matsuhiko Nishizawa,et al.  Conducting polymer electrodes printed on hydrogel. , 2010, Journal of the American Chemical Society.

[20]  Gymama E. Slaughter,et al.  Electrical and electrochemical characterization of electroconductive PPy-p(HEMA) composite hydrogels , 2003, SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring.

[21]  Jennifer T. Blundo,et al.  Effect of Poly(vinyl alcohol) Macromer Chemistry and Chain Interactions on Hydrogel Mechanical Properties , 2007 .

[22]  Gordon G Wallace,et al.  Polypyrrole-coated electrodes for the delivery of charge and neurotrophins to cochlear neurons. , 2009, Biomaterials.

[23]  David C. Martin,et al.  Structural, chemical and electrochemical characterization of poly(3,4-ethylenedioxythiophene) (PEDOT) prepared with various counter-ions and heat treatments. , 2011, Polymer.

[24]  Daryl R Kipke,et al.  Conducting polymers on hydrogel-coated neural electrode provide sensitive neural recordings in auditory cortex. , 2010, Acta biomaterialia.

[25]  L. M. Lira,et al.  Conducting polymer- hydrogel blends for electrochemically controlled drug release devices , 2008 .

[26]  T. Hayakawa,et al.  Head‐to‐tail regioregularity of poly(3‐hexylthiophene) in oxidative coupling polymerization with FeCl3 , 1999 .

[27]  S. Armes,et al.  SYNTHESIS AND CHARACTERIZATION OF SUBMICROMETER-SIZED POLYPYRROLE-POLYSTYRENE COMPOSITE PARTICLES , 1999 .

[28]  Synthesis, characterization and in vitro cell compatibility study of a poly(amic acid) graft/cross-linked poly(vinyl alcohol) hydrogel. , 2011, Acta biomaterialia.

[29]  M. Deepa,et al.  Poly(3,4-ethylenedioxythiophene) (PEDOT)-coated MWCNTs tethered to conducting substrates: facile electrochemistry and enhanced coloring efficiency , 2008 .

[30]  J. Dual,et al.  Mechanical Properties of the Intrinsically Conductive Polymer Poly(3,4- Ethylenedioxythiophene) Poly(Styrenesulfonate) (PEDOT/PSS) , 2007 .

[31]  Joseph F Rizzo,et al.  Selective activation of neuronal targets with sinusoidal electric stimulation. , 2010, Journal of neurophysiology.

[32]  Xiliang Luo,et al.  Highly stable carbon nanotube doped poly(3,4-ethylenedioxythiophene) for chronic neural stimulation. , 2011, Biomaterials.

[33]  Daryl R. Kipke,et al.  Conducting-polymer nanotubes improve electrical properties, mechanical adhesion, neural attachment, and neurite outgrowth of neural electrodes. , 2010, Small.

[34]  G. Wallace,et al.  Conducting polymers for neural interfaces: challenges in developing an effective long-term implant. , 2008, Biomaterials.

[35]  N. H. Lovell,et al.  Novel neural interface for implant electrodes: improving electroactivity of polypyrrole through MWNT incorporation , 2008, Journal of materials science. Materials in medicine.

[36]  G. Wallace,et al.  Responsive conducting polymer-hydrogel composites , 1997 .

[37]  David C. Martin,et al.  Conducting polymers grown in hydrogel scaffolds coated on neural prosthetic devices. , 2004, Journal of biomedical materials research. Part A.

[38]  L. Poole-Warren,et al.  Conducting polymer-hydrogels for medical electrode applications , 2010, Science and technology of advanced materials.

[39]  William R. Stauffer,et al.  Polypyrrole doped with 2 peptide sequences from laminin. , 2006, Biomaterials.

[40]  G Foffani,et al.  Deep brain stimulation in Parkinson's disease can mimic the 300 Hz subthalamic rhythm. , 2006, Brain : a journal of neurology.

[41]  L. M. Lira,et al.  Conducting polymer–hydrogel composites for electrochemical release devices: Synthesis and characterization of semi-interpenetrating polyaniline–polyacrylamide networks , 2005 .

[42]  R. Larsson,et al.  Heparin coating durability on artificial heart valves studied by XPS and antithrombin binding capacity. , 2006, Colloids and surfaces. B, Biointerfaces.

[43]  J M Carmena,et al.  In Vitro and In Vivo Evaluation of PEDOT Microelectrodes for Neural Stimulation and Recording , 2011, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[44]  V. Pillay,et al.  A Polyvinyl Alcohol-Polyaniline Based Electro-Conductive Hydrogel for Controlled Stimuli-Actuable Release of Indomethacin , 2011 .

[45]  S. Armes,et al.  Synthesis and Characterization of Micrometer-Sized, Polyaniline-Coated Polystyrene Latexes , 1998 .

[46]  G. Wallace,et al.  In-situ mechanical properties of tosylate doped (pts) polypyrrole , 1997 .

[47]  Clelia Dispenza,et al.  Electrically conductive hydrogel composites made of polyaniline nanoparticles and poly(N-vinyl-2-pyrrolidone) , 2006 .

[48]  A. Teja,et al.  Supercritical carbon dioxide processing of conducting composites of polypyrrole and porous crosslinked polystyrene , 2006 .

[49]  Mohammad Reza Abidian,et al.  Multifunctional Nanobiomaterials for Neural Interfaces , 2009 .

[50]  K. Ho,et al.  A high-performance counter electrode based on poly(3,4-alkylenedioxythiophene) for dye-sensitized solar cells , 2009 .