Respiratory Virus Epidemiology Among US Infants With Severe Bronchiolitis: Analysis of 2 Multicenter, Multiyear Cohort Studies.

In 2 multicenter cohort studies of 2912 infants hospitalized for bronchiolitis during 2007-2014, the 5 most common pathogens were RSV (76.5%), rhinovirus (23.8%), coronavirus (6.9%), adenovirus (6.4%) and human metapneumovirus (6.0%). Hospitalization months significantly differed for these common pathogens (P ≤ 0.01), except for coronavirus (P = 0.30). There was a significant heterogeneity in temporal patterns by region in RSV-A and -B (both P < 0.001).

[1]  C. Camargo,et al.  Severe bronchiolitis profiles and risk of recurrent wheeze by age 3 years , 2019, The Journal of allergy and clinical immunology.

[2]  J. Celedón,et al.  Nasopharyngeal CCL5 in infants with severe bronchiolitis and risk of recurrent wheezing: A multi‐center prospective cohort study , 2018, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[3]  Christopher M. Taylor,et al.  Lactobacillus reuteri for Infants with Colic: A Double‐Blind, Placebo‐Controlled, Randomized Clinical Trial , 2017, The Journal of pediatrics.

[4]  W. Busse,et al.  Effects of Omalizumab on Rhinovirus Infections, Illnesses, and Exacerbations of Asthma , 2017, American journal of respiratory and critical care medicine.

[5]  Marie E Killerby,et al.  Human coronavirus circulation in the United States 2014–2017 , 2018, Journal of Clinical Virology.

[6]  Xiaoyan Lu,et al.  Human Adenovirus Surveillance — United States, 2003–2016 , 2017, MMWR. Morbidity and mortality weekly report.

[7]  E. Simões,et al.  Palivizumab Prophylaxis in Preterm Infants and Subsequent Recurrent Wheezing. Six‐Year Follow‐up Study , 2017, American journal of respiratory and critical care medicine.

[8]  A. Fowlkes,et al.  Human Metapneumovirus Circulation in the United States, 2008 to 2014 , 2016, Pediatrics.

[9]  V. Lionetti,et al.  The Efficacy and Safety of the Probiotic Bacterium Lactobacillus reuteri DSM 17938 for Infantile Colic: A Meta-Analysis of Randomized Controlled Trials , 2015, PloS one.

[10]  C. Camargo,et al.  Respiratory Syncytial Virus Genomic Load and Disease Severity Among Children Hospitalized With Bronchiolitis: Multicenter Cohort Studies in the United States and Finland , 2014, The Journal of infectious diseases.

[11]  Eneida A. Mendonça,et al.  Clinical Practice Guideline: The Diagnosis, Management, and Prevention of Bronchiolitis , 2014, Pediatrics.

[12]  Rob Lambkin-Williams,et al.  Oral GS-5806 activity in a respiratory syncytial virus challenge study. , 2014, The New England journal of medicine.

[13]  C. Camargo,et al.  Infectious pathogens and bronchiolitis outcomes , 2014, Expert review of anti-infective therapy.

[14]  M. Kosek,et al.  A phase one safety study of Lactobacillus reuteri conducted in the Peruvian Amazon: Observations from the field. , 2014, The American journal of tropical medicine and hygiene.

[15]  C. Camargo,et al.  Trends in Bronchiolitis Hospitalizations in the United States, 2000–2009 , 2013, Pediatrics.

[16]  F. Guarner,et al.  An update on the use and investigation of probiotics in health and disease , 2013, Gut.

[17]  M. Prill,et al.  Respiratory Syncytial Virus Activity — United States, July 2011–January 2013 , 2013, MMWR. Morbidity and mortality weekly report.

[18]  J. Linder,et al.  Human rhinovirus C: Age, season, and lower respiratory illness over the past 3 decades , 2012, Journal of Allergy and Clinical Immunology.

[19]  P. Szilagyi,et al.  Human rhinovirus species associated with hospitalizations for acute respiratory illness in young US children. , 2011, The Journal of infectious diseases.

[20]  M. Sanders.  Impact of Probiotics on Colonizing Microbiota of the Gut , 2011, Journal of clinical gastroenterology.

[21]  S. Roos,et al.  Removal of Antibiotic Resistance Gene-Carrying Plasmids from Lactobacillus reuteri ATCC 55730 and Characterization of the Resulting Daughter Strain, L. reuteri DSM 17938 , 2008, Applied and Environmental Microbiology.

[22]  Larry J. Anderson,et al.  Rhinovirus-Associated Hospitalizations in Young Children , 2007, The Journal of infectious diseases.

[23]  R. Miniero,et al.  Lactobacillus reuteri (American Type Culture Collection Strain 55730) Versus Simethicone in the Treatment of Infantile Colic: A Prospective Randomized Study , 2007, Pediatrics.

[24]  Hyun Seung Lee,et al.  The Therapeutic Effect of Lactobacillus reuteri in Acute Diarrhea in Infants and Toddlers , 2005 .

[25]  R. Oberhelman,et al.  Probiotic agents and infectious diseases: a modern perspective on a traditional therapy. , 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[26]  H. Mykkänen,et al.  Lactobacillus reuteri as a therapeutic agent in acute diarrhea in young children. , 1997, Journal of pediatric gastroenterology and nutrition.