Best Practices for Intrathecal Drug Delivery for Pain

The objective of this study was to identify best practices and provide guidance to clinicians to ensure safety and optimize intrathecal drug delivery for chronic intractable pain.

[1]  P. Phelps,et al.  Intrathecal drug therapy for long-term pain management. , 2007, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.

[2]  C. Bernards.  Cerebrospinal Fluid and Spinal Cord Distribution of Baclofen and Bupivacaine during Slow Intrathecal Infusion in Pigs , 2006, Anesthesiology.

[3]  N. Pace,et al.  Dose‐Response Pharmacology of Intrathecal Morphine in Human Volunteers , 1993, Anesthesiology.

[4]  A. Burton,et al.  Considerations and methodology for trialing ziconotide. , 2010, Pain physician.

[5]  R. Coffey,et al.  Mortality Associated with Implantation and Management of Intrathecal Opioid Drug Infusion Systems to Treat Noncancer Pain , 2009, Anesthesiology.

[6]  E. Krames,et al.  Clinical realities and economic considerations: patient selection in intrathecal therapy. , 1997, Journal of pain and symptom management.

[7]  R. Scheffler,et al.  Supply dynamics of the mental health workforce: implications for health policy. , 1998, The Milbank quarterly.

[8]  S. Hassenbusch,et al.  Management of Intrathecal Catheter‐Tip Inflammatory Masses: An Updated 2007 Consensus Statement From An Expert Panel , 2008, Neuromodulation : journal of the International Neuromodulation Society.

[9]  S Benjamin,et al.  The association between chronic widespread pain and mental disorder: a population-based study. , 2000, Arthritis and rheumatism.

[10]  M. Gofeld,et al.  Ultrasound-guided intrathecal pump access and prevention of the pocket fill. , 2011, Pain medicine.

[11]  J. Mao,et al.  Opioid therapy for chronic pain. , 2003, The New England journal of medicine.

[12]  G. Goldstein,et al.  Blood—Brain—Cerebrospinal Fluid Barriers , 1999 .

[13]  G. Fanelli,et al.  Opioid‐related side‐effects after intrathecal morphine: a prospective, randomized, double‐blind dose–response study , 2006, European journal of anaesthesiology.

[14]  Gerhard Friehs,et al.  Intrathecal drug delivery for the management of cancer pain: a multidisciplinary consensus of best clinical practices. , 2005, The journal of supportive oncology.

[15]  L. Tonder,et al.  Intrathecal drug delivery for treatment of chronic low back pain: report from the National Outcomes Registry for Low Back Pain. , 2004, Pain medicine.

[16]  C. Bernards,et al.  Comparative Spinal Distribution and Clearance Kinetics of Intrathecally Administered Morphine, Fentanyl, Alfentanil, and Sufentanil , 2000, Anesthesiology.

[17]  J. Rathmell,et al.  Death after initiation of intrathecal drug therapy for chronic pain: assessing risk and designing prevention. , 2009, Anesthesiology.

[18]  W. Cheadle,et al.  Chlorhexidine-Alcohol Versus Povidone-Iodine for Surgical Site Antisepsis , 2011 .

[19]  Michael Negraeff.  Chronic Pain: An Integrated Biobehavioral Approach , 2012, Canadian Journal of Anesthesia/Journal canadien d'anesthésie.

[20]  E. Poleshuck.  What Research Can and Cannot Tell Us About Psychotherapy for Pain: Psychosocial Interventions for Chronic Pain: In Search of Evidence , 2009 .

[21]  J. Prager,et al.  Evaluation of Patients for Implantable Pain Modalities: Medical and Behavioral Assessment , 2001, The Clinical journal of pain.

[22]  S. Hassenbusch,et al.  A Consensus Statement Regarding the Present Suggested Titration for Prialt (Ziconotide) , 2005, Neuromodulation (Malden, Mass.).

[23]  W. Winkelmüller,et al.  Long-term effects of continuous intrathecal opioid treatment in chronic pain of nonmalignant etiology. , 1996, Journal of neurosurgery.

[24]  R. Coffey,et al.  Inflammatory Mass Lesions Associated with Intrathecal Drug Infusion Catheters: Report and Observations on 41 Patients , 2001, Neurosurgery.

[25]  T. Deer,et al.  Intrathecal Therapy for Cancer and Nonmalignant Pain: Patient Selection and Patient Management , 1999, Neuromodulation : journal of the International Neuromodulation Society.

[26]  E. Krames.  Intraspinal opioid therapy for chronic nonmalignant pain: current practice and clinical guidelines. , 1996, Journal of pain and symptom management.

[27]  K J Burchiel,et al.  A prospective study of long-term intrathecal morphine in the management of chronic nonmalignant pain. , 1999, Neurosurgery.

[28]  G. Pasternak,et al.  Individual variability in the response to different opioids: report of five cases , 1992, Pain.

[29]  E. Buchser,et al.  Patient‐Controlled Analgesia in Chronic Pain Patients: Experience with a New Device Designed to be Used with Implanted Programable Pumps , 2008, Pain practice : the official journal of World Institute of Pain.

[30]  M. Dehghani,et al.  Does a Combination of Intensive Cognitive‐Behavioral Pain Management and a Spinal Implantable Device Confer any Advantage? A Preliminary Examination , 2006, Pain practice : the official journal of World Institute of Pain.

[31]  M. Saulino,et al.  Polyanalgesic Consensus Conference 2012: Recommendations for the Management of Pain by Intrathecal (Intraspinal) Drug Delivery: Report of an Interdisciplinary Expert Panel , 2012, Neuromodulation : journal of the International Neuromodulation Society.

[32]  Howard S. Smith,et al.  Safety and efficacy of intrathecal ziconotide in the management of severe chronic pain , 2009, Therapeutics and clinical risk management.

[33]  S. Hassenbusch,et al.  Polyanalgesic Consensus Conference 2007: Recommendations for the Management of Pain by Intrathecal (Intraspinal) Drug Delivery: Report of an Interdisciplinary Expert Panel , 2007, Neuromodulation : journal of the International Neuromodulation Society.

[34]  Teresa C. Horan,et al.  Guideline for Prevention of Surgical Site Infection, 1999 , 1999, Infection Control & Hospital Epidemiology.

[35]  T. Deer.  A critical time for practice change in the pain treatment continuum: we need to reconsider the role of pumps in the patient care algorithm. , 2010, Pain medicine.

[36]  M. Byas-Smith,et al.  Intrathecal Ziconotide in the Treatment of Chronic Nonmalignant Pain: A Randomized, Double‐Blind, Placebo‐Controlled Clinical Trial , 2006, Neuromodulation : journal of the International Neuromodulation Society.

[37]  C. Bernards,et al.  Morphine Distribution in the Spinal Cord After Chronic Infusion in Pigs , 2011, Anesthesia and analgesia.

[38]  R. Patt.  Spinal opioids: distinguishing trend from science. , 1993, Journal of pain and symptom management.

[39]  M. Cousins.  International association for the study of pain , 1989, Pain.

[40]  M. Wallace,et al.  Intrathecal Ziconotide for Severe Chronic Pain: Safety and Tolerability Results of an Open-Label, Long-Term Trial , 2008, Anesthesia and analgesia.

[41]  Hua Li,et al.  Protective effect of topical antibiotics in breast augmentation. , 2013, Plastic and reconstructive surgery.

[42]  A. Koulousakis,et al.  Drug Adverse Events and System Complications of Intrathecal Opioid Delivery for Pain: Origins, Detection, Manifestations, and Management , 1999, Neuromodulation : journal of the International Neuromodulation Society.

[43]  M. Greenberg,et al.  Transition from acute to chronic pain and disability: A model including cognitive, affective, and trauma factors , 2008, Pain.

[44]  J. van Buyten,et al.  Endocrine consequences of long-term intrathecal administration of opioids. , 2000, The Journal of clinical endocrinology and metabolism.

[45]  A. L. Albright,et al.  Best-practice surgical techniques for intrathecal baclofen therapy. , 2006, Journal of neurosurgery.

[46]  R. Coffey,et al.  Medical practice perspective: identification and mitigation of risk factors for mortality associated with intrathecal opioids for non-cancer pain. , 2010, Pain medicine.

[47]  J. Prager.  Minimizing the Risks of Intrathecal Therapy , 2012 .

[48]  D. Long,et al.  Spinal cord compression complicating subarachnoid infusion of morphine: case report and laboratory experience. , 1991, Neurosurgery.

[49]  Michael C. Mosier,et al.  Chlorhexidine-Alcohol versus Povidone-Iodine for Surgical-Site Antisepsis. , 2010, The New England journal of medicine.

[50]  L. Mather,et al.  Intrathecal and epidural administration of opioids. , 1984, Anesthesiology.

[51]  S. D. Pen,et al.  The dilemma of opioid conversion in intrathecal therapy , 2003 .

[52]  T. Horan,et al.  Guideline for Prevention of Surgical Site Infection, 1999. Centers for Disease Control and Prevention (CDC) Hospital Infection Control Practices Advisory Committee. , 1999, American journal of infection control.

[53]  S. Hassenbusch,et al.  Inflammatory masses associated with intrathecal drug infusion: a review of preclinical evidence and human data. , 2002, Pain medicine.

[54]  R. Wilkins,et al.  Wound cleaning and wound healing: a concise review. , 2013, Advances in Skin & Wound Care.

[55]  J. Turner,et al.  Programmable Intrathecal Opioid Delivery Systems for Chronic Noncancer Pain: A Systematic Review of Effectiveness and Complications , 2007, The Clinical journal of pain.

[56]  X. Ruan.  Drug-related side effects of long-term intrathecal morphine therapy. , 2007, Pain physician.

[57]  E. Krames.  Intrathecal infusional therapies for intractable pain: patient management guidelines. , 1993, Journal of pain and symptom management.

[58]  P. Rawlins,et al.  The diagnosis of intrathecal infusion pump system failure. , 2005, Pain physician.

[59]  J. Drake,et al.  Prevention and Management of Intrathecal Drug Delivery and Spinal Cord Stimulation System Infections , 2004, Anesthesiology.

[60]  J. Taha,et al.  Correlation between Withdrawal Symptoms and Medication Pump Residual Volume in Patients with Implantable SynchroMed Pumps , 2004, Neurosurgery.

[61]  T. Horan,et al.  Guideline for prevention of surgical site infection. , 2000, Bulletin of the American College of Surgeons.

[62]  T. Yaksh,et al.  Continuous low-dose intrathecal morphine administration in the treatment of chronic pain of malignant origin. , 1981, Mayo Clinic proceedings.

[63]  J. Aldrete,et al.  Leg edema from intrathecal opiate infusions , 2000, European journal of pain.

[64]  Chourouk Mzahi.  Reshaping the Village Test for investigating service brand attachment , 2014 .

[65]  M. Saulino,et al.  Polyanalgesic Consensus Conference—2012: Consensus on Diagnosis, Detection, and Treatment of Catheter‐Tip Granulomas (Inflammatory Masses) , 2012, Neuromodulation : journal of the International Neuromodulation Society.

[66]  Howard S. Smith,et al.  Consensus guidelines for the selection and implantation of patients with noncancer pain for intrathecal drug delivery. , 2010, Pain physician.

[67]  R. Roy.  Psychosocial Interventions for Chronic Pain , 2008 .

[68]  S. Hassenbusch,et al.  Polyanalgesic Consensus Conference 2003: an update on the management of pain by intraspinal drug delivery-- report of an expert panel. , 2004, Journal of pain and symptom management.

[69]  R. Sylvester,et al.  The conversion challenge: From intrathecal to oral morphine , 2004, The American journal of hospice & palliative care.

[70]  T. Deer,et al.  Prevention of Intrathecal Drug Delivery Catheter‐Related Complications , 2003, Neuromodulation : journal of the International Neuromodulation Society.

[71]  J. L. Swisher,et al.  Practice Guidelines for the Prevention, Detection, and Management of Respiratory Depression Associated with Neuraxial Opioid Administration , 2007, Anesthesiology.

[72]  Li Hui Chen,et al.  Increase in fatal poisonings involving opioid analgesics in the United States, 1999-2006. , 2009, NCHS data brief.

[73]  K. Burchiel,et al.  Intrathecal hydromorphone for chronic nonmalignant pain: a retrospective study. , 2001, Pain medicine.

[74]  L. Webster,et al.  A randomized, double-blind, placebo-controlled study of intrathecal ziconotide in adults with severe chronic pain. , 2006, Journal of pain and symptom management.

[75]  M. Chaney.  Side effects of intrathecal and epidural opioids , 1995, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[76]  P. Hrdina.  Basic Neurochemistry: Molecular, Cellular and Medical Aspects. , 1996 .

[77]  M. Corrigan,et al.  The role of topical antibiotics used as prophylaxis in surgical site infection prevention. , 2011, The Journal of antimicrobial chemotherapy.

[78]  Christopher Eccleston,et al.  Psychological therapies for the management of chronic pain (excluding headache) in adults. , 2012, The Cochrane database of systematic reviews.