论文信息 - Comment on mathematical models which describe transcription and calculate the relationship between mRNA and protein expression ratio.

Comment on mathematical models which describe transcription and calculate the relationship between mRNA and protein expression ratio.

Mathematical models to describe transcription (Arnold et al. (2001); Biotech Bioeng 72:548-561) and translation (Mehra et al. (2003); Biotech Bioeng 84:822-841) in bacteria are modified in order to improve reaction kinetics and to include the number of polymerase molecules that are active on the DNA, as well as to include the number of ribosomes that are active on the nascent and on the completed mRNA, respectively.

A Kremling | A. Kremling

[1] H. Riezman,et al. Transcription and translation initiation frequencies of the Escherichia coli lac operon. , 1977, Journal of molecular biology.

[2] D. Drew. A mathematical model for prokaryotic protein synthesis , 2001, Bulletin of mathematical biology.

[3] Donald A Drew,et al. A mathematical model for elongation of a peptide chain , 2003, Bulletin of mathematical biology.

[4] H. Bremer. Modulation of Chemical Composition and Other Parameters of the Cell by Growth Rate , 1999 .

[5] Vassily Hatzimanikatis,et al. Insights into the relation between mRNA and protein expression patterns: I. theoretical considerations , 2003, Biotechnology and bioengineering.

[6] Vassily Hatzimanikatis,et al. An algorithmic framework for genome-wide modeling and analysis of translation networks. , 2006, Biophysical journal.

[7] M. Reuss,et al. Kinetic modeling and simulation of in vitro transcription by phage T7 RNA polymerase. , 2001, Biotechnology and bioengineering.