Electrochemical Biosensors for Cancer Detection Using Different Biomarkers

Cancer detecting at an early stage, can save lives and increases the chance of treatment. For diagnosing cancer, antigens related to tumor have been used as biomarkers in order to diagnose cancer. These includes molecules related to tumor cells, and body fluids like urine and blood that are over-expressed as a result of cancer development. A range of biomarkers of different cancer types have been identified so far. Biomarkers including "Okadaic Acid", "Nucleic Acid", "Protein-Based", are the main criterions for some cancers and they are the approach of this paper. There are some Electrochemical Biosensors called point-of-care categorized as a biomarkers diagnostic devices, they provide applicable choices which helps in quick and accurate analysis and detection of cancer symptoms. In this paper, a simulation based on Electrochemical Impedance Spectroscopy is presented which is a practical and reliable tool for identifying biological materials, such as cancer biomarkers.

[1]  N. Hu,et al.  High-sensitive detection of okadaic acid using human bronchial epithelial cell-based impedance biosensor , 2017, 2017 ISOCS/IEEE International Symposium on Olfaction and Electronic Nose (ISOEN).

[2]  A. Das,et al.  Recent advances in biosensor development for the detection of cancer biomarkers. , 2017, Biosensors & bioelectronics.

[3]  U. Rajendra Acharya,et al.  Detection and differentiation of breast cancer using neural classifiers with first warning thermal sensors , 2007, Inf. Sci..

[4]  Jianfeng Zhou,et al.  Selective bio-labeling and induced apoptosis of hematopoietic cancer cells using dual-functional polyethylenimine-caged platinum nanoclusters. , 2018, Biochemical and biophysical research communications.

[5]  Chao Yang,et al.  On-Chip Electrochemical Impedance Spectroscopy for Biosensor Arrays , 2006, 2006 5th IEEE Conference on Sensors.

[6]  Anne Vincent-Salomon,et al.  Enrichment methods to detect bone marrow micrometastases in breast carcinoma patients: clinical relevance , 2004, Breast Cancer Research.

[7]  P. Bottoni,et al.  Neuron-Specific Enolase as a Biomarker: Biochemical and Clinical Aspects. , 2015, Advances in experimental medicine and biology.

[8]  I. Palchetti,et al.  Photoelectrochemical genosensors for the determination of nucleic acid cancer biomarkers , 2018, Current Opinion in Electrochemistry.

[9]  Jie Wu,et al.  A disposable two-throughput electrochemical immunosensor chip for simultaneous multianalyte determination of tumor markers. , 2007, Biosensors & bioelectronics.

[10]  Feng Yan,et al.  Biomedical and clinical applications of immunoassays and immunosensors for tumor markers , 2007 .

[11]  J. Ross Macdonald,et al.  Impedance spectroscopy , 2006, Annals of Biomedical Engineering.

[12]  A. Sacco.  Electrochemical impedance spectroscopy: Fundamentals and application in dye-sensitized solar cells , 2017 .

[13]  I. Tothill.  Biosensors for cancer markers diagnosis. , 2009, Seminars in cell & developmental biology.

[14]  Xiaolei Zuo,et al.  Nucleic acid-based electrochemical nanobiosensors. , 2018, Biosensors & bioelectronics.

[15]  Blessy Baby Mathew,et al.  Biosensors: A Modern Day Achievement , 2014 .

[16]  Incorporating observability thresholds of tumors into the two-stage carcinogenesis model. , 2000, Mathematical biosciences.

[17]  Huijie Yang,et al.  Network-based identification of reliable bio-markers for cancers. , 2015, Journal of theoretical biology.