Passive mixers in microfluidic systems: A review

Abstract The aim of microfluidic mixing is to achieve a thorough and rapid mixing of multiple samples in microscale devices. In such devices, sample mixing is essentially achieved by enhancing the diffusion effect between the different species flows. Passive micromixers utilize no energy input other than the pressure head used to drive the fluid flow at a constant rate. Under such conditions, the flow has a laminar characteristic, and hence mixing relies mainly on the induction of a chaotic advection effect to increase the contact surface and contact time between the species flows. Many passive mixers have been proposed to facilitate this task over the past five years. The details of these mixers are briefly described in the following review.

[1]  M. A. Ansari,et al.  A novel passive micromixer based on unbalanced splits and collisions of fluid streams , 2010 .

[2]  Chia-Yuan Chen,et al.  Efficient micromixing through artificial cilia actuation with fish-schooling configuration , 2015 .

[3]  D. Marchisio,et al.  Flow field simulation and mixing efficiency assessment of the multi-inlet vortex mixer for molybdenum sulfide nanoparticle precipitation , 2014 .

[4]  Kwang-Yong Kim,et al.  Convergent–divergent micromixer coupled with pulsatile flow , 2015 .

[5]  Dong-Yol Yang,et al.  Three-dimensionally crossing manifold micro-mixer for fast mixing in a short channel length. , 2011, Lab on a chip.

[6]  F. He,et al.  Three-dimensional staggered herringbone mixer fabricated by femtosecond laser direct writing , 2013 .

[7]  Z. P. Wang,et al.  A microfluidic mixer with self-excited 'turbulent' fluid motion for wide viscosity ratio applications. , 2010, Lab on a chip.

[8]  Yong Jin,et al.  Visualization of micro-scale mixing in miscible liquids using μ-LIF technique and drug nano-particle preparation in T-shaped micro-channels , 2012 .

[9]  Kwang-Yong Kim,et al.  Analysis and optimization of a micromixer with a modified Tesla structure , 2010 .

[10]  Kwang-Yong Kim,et al.  Passive split and recombination micromixer with convergent–divergent walls , 2012 .

[11]  Kwang-Yong Kim,et al.  Mixing performance of unbalanced split and recombine micomixers with circular and rhombic sub-channels , 2010 .

[12]  Denz Lee,et al.  On the enhancement of mixing in tangentially crossing micro-channels , 2012 .

[13]  An-Shik Yang,et al.  A novel vortex mixer actuated by one-shot electricity-free pumps , 2013 .

[14]  Huaizhi Li,et al.  Pressure drop in a split‐and‐recombine caterpillar micromixer in case of newtonian and non‐newtonian fluids , 2013 .

[15]  Harrson Silva Santana,et al.  Numerical simulation of mixing and reaction of Jatropha curcas oil and ethanol for synthesis of biodiesel in micromixers , 2015 .

[16]  Chih-Yang Wu,et al.  Crosswise ridge micromixers with split and recombination helical flows , 2011 .

[17]  Kwang-Yong Kim,et al.  Vortex micro T-mixer with non-aligned inputs , 2012 .

[18]  H. Hsu,et al.  Novel design and fabrication of a geometrical obstacle-embedded micromixer with notched wall , 2014 .

[19]  Dominique M. Roberge,et al.  Liquid–liquid flow regimes and mass transfer in various micro-reactors , 2016 .

[20]  Patrick D. Anderson,et al.  The Effect of Inertia on the Flow and Mixing Characteristics of a Chaotic Serpentine Mixer , 2014, Micromachines.

[21]  Christophe A. Serra,et al.  Micromixer-assisted polymerization processes , 2011 .

[22]  Akira Goto,et al.  Analysis and multi-criteria design optimization of geometric characteristics of grooved micromixer , 2010 .

[23]  Kwang-Yong Kim,et al.  Three-objective optimization of a staggered herringbone micromixer , 2014 .

[24]  Tao Dong,et al.  An effective passive micromixer with shifted trapezoidal blades using wide Reynolds number range , 2015 .

[25]  T. R. Shih,et al.  Design and mixing efficiency of rhombic micromixer with flat angles , 2010 .

[26]  J. Harting,et al.  Quantification of the performance of chaotic micromixers on the basis of finite time Lyapunov exponents , 2010, 1012.5549.

[27]  H. L. Dryden,et al.  Investigations on the Theory of the Brownian Movement , 1957 .

[28]  Kwang-Yong Kim,et al.  Mixing Analysis of Passive Micromixer with Unbalanced Three-Split Rhombic Sub-Channels , 2014, Micromachines.

[29]  Chien-Hsiung Tsai,et al.  Rapid magnetic microfluidic mixer utilizing AC electromagnetic field , 2009, Electrophoresis.

[30]  Hyung Hee Cho,et al.  Optimization of microscale vortex generators in a microchannel using advanced response surface method , 2011 .

[31]  Mohammad Nimafar,et al.  A novel generation of 3D SAR-based passive micromixer: efficient mixing and low pressure drop at a low Reynolds number , 2013 .

[32]  L. Fu,et al.  An integrated microfluidic chip for formaldehyde analysis in Chinese herbs , 2014 .

[33]  Sangmo Kang,et al.  A Review on Mixing in Microfluidics , 2010, Micromachines.

[34]  J. Denayer,et al.  A micromixer with consistent mixing performance for a wide range of flow rates , 2015, Electrophoresis.

[35]  Hamid Latifi,et al.  Simulation and experimental investigation of planar micromixers with short-mixing-length , 2013 .

[36]  Hongyuan Jiang,et al.  An effective splitting-and-recombination micromixer with self-rotated contact surface for wide Reynolds number range applications. , 2013, Biomicrofluidics.

[37]  An-Shik Yang,et al.  A high-performance micromixer using three-dimensional Tesla structures for bio-applications , 2015 .

[38]  Muthukumaran Packirisamy,et al.  High performance cascaded PDMS micromixer based on split-and-recombination flows for lab-on-a-chip applications , 2013 .

[39]  Samir Bensaid,et al.  MoS2 nanoparticle precipitation in turbulent micromixers , 2012 .

[40]  C. Dubois,et al.  Free-radical polymerization of styrene using a split-and-recombination (SAR) and multilamination microreactors , 2014 .

[41]  Jian Li,et al.  Numerical and experimental analyses of planar asymmetric split‐and‐recombine micromixer with dislocation sub‐channels , 2013 .

[42]  Kai Yo Hsiao,et al.  Fluid mixing in a microchannel with longitudinal vortex generators , 2014 .

[43]  Vladimir Viktorov,et al.  Experimental comparative mixing performance of passive micromixers with H-shaped sub-channels , 2012 .

[44]  Davoud Jafari,et al.  Mixing enhancement in a passive micromixer with convergent–divergent sinusoidal microchannels and different ratio of amplitude to wave length , 2014 .

[45]  Chi-Tay Tsai,et al.  Three Dimensional Triangle Chaotic Micromixer , 2014 .

[46]  Chih-Yang Wu,et al.  An efficient micromixer based on multidirectional vortices due to baffles and channel curvature. , 2011, Biomicrofluidics.

[47]  Lung-Ming Fu,et al.  Integrated microfluidic array chip and LED photometer system for sulfur dioxide and methanol concentration detection , 2014 .

[48]  Numerical analysis of a rapid magnetic microfluidic mixer , 2011, Electrophoresis.

[49]  C. Galletti,et al.  Numerical Study of Split T‐Micromixers , 2012 .

[50]  Kyoung Duck Seo,et al.  A chaotic micromixer using obstruction-pairs , 2009 .

[51]  D. Roberge,et al.  WITHDRAWN: Liquid–liquid flow regimes and mass transfer in various micro-reactors , 2014 .

[52]  Yan Du,et al.  Evaluation of Floor-grooved Micromixers using Concentration-channel Length Profiles , 2010, Micromachines.

[53]  Chieh-Li Chen,et al.  Mixing enhancement of electrokinetically-driven non-Newtonian fluids in microchannel with patterned blocks , 2012 .

[54]  Oliver Geschke,et al.  A novel passive micromixer: lamination in a planar channel system , 2010 .

[55]  Ying Lin,et al.  Numerical characterization of simple three-dimensional chaotic micromixers , 2015 .

[56]  Shou-Shing Hsieh,et al.  Mixing efficiency of Y-type micromixers with different angles , 2013 .

[57]  Huiying Wu,et al.  Design and simulation of passive micromixers based on capillary , 2012 .

[58]  Zhengdong Wang,et al.  Design and evaluation of an easily fabricated micromixer with three-dimensional periodic perturbation , 2011 .

[59]  Michael J. Vellekoop,et al.  A highly uniform lamination micromixer with wedge shaped inlet channels for time resolved infrared spectroscopy , 2011 .

[60]  Nam-Trung Nguyen,et al.  Micromixers?a review , 2005 .

[61]  U. Kragl,et al.  Application of microstructured devices for continuous synthesis of tailored platinum nanoparticles , 2013 .

[62]  Péter Fürjes,et al.  Optimized Simulation and Validation of Particle Advection in Asymmetric Staggered Herringbone Type Micromixers , 2014, Micromachines.

[63]  Thomas Henkel,et al.  Numerical and experimental investigations of mixing in T-shaped and cross-shaped micromixers , 2012 .

[64]  T. R. Shih,et al.  Design and experiments of a short-mixing-length baffled microreactor and its application to microfluidic synthesis of nanoparticles , 2011 .

[65]  Michael C. L. Ward,et al.  Investigation of mixing in a cross-shaped micromixer with static mixing elements for reaction kinetics studies , 2003 .

[66]  Valery Rudyak,et al.  Modeling and Optimization of Y-Type Micromixers , 2014, Micromachines.

[67]  A Bertsch,et al.  Static micromixers based on large-scale industrial mixer geometry. , 2001, Lab on a chip.

[68]  Lei Wang,et al.  Mixing enhancement of novel passive microfluidic mixers with cylindrical grooves , 2012 .

[69]  Dong Sung Kim,et al.  A centrifugal force-based serpentine micromixer (CSM) on a plastic lab-on-a-disk for biochemical assays , 2013 .

[70]  L. Fu,et al.  Microfluidic Mixing: A Review , 2011, International journal of molecular sciences.

[71]  Jyh Jian Chen,et al.  Mixing of a split and recombine micromixer with tapered curved microchannels , 2012 .

[72]  Gang Qian,et al.  Gas–liquid mixing in a multi-scale micromixer with arborescence structure , 2011 .

[73]  Combined improved mixing and reduced energy dissipation by combining convective effects and lamination , 2012 .

[74]  Ruiqi Shen,et al.  Mixing enhancement by simple periodic geometric features in microchannels , 2012 .

[75]  Huimin Ma,et al.  Design and Fabrication of a Three Dimensional Spiral Micromixer , 2013 .

[76]  An-Shik Yang,et al.  CFD-Based Optimization of a Diamond-Obstacles Inserted Micromixer with Boundary Protrusions , 2011 .

[77]  K. Nishino,et al.  Swirl-inducing inlet for passive micromixers , 2014 .

[78]  J. Chen,et al.  Interfacial configurations and mixing performances of fluids in staggered curved-channel micromixers , 2011, 2011 Symposium on Design, Test, Integration & Packaging of MEMS/MOEMS (DTIP).

[79]  Kwang-Yong Kim,et al.  Shape optimization of a micromixer with staggered-herringbone grooves patterned on opposite walls , 2010 .