Pathophysiological relevance of aldehydic protein modifications.

[1]  D. Butterfield,et al.  Lipid peroxidation triggers neurodegeneration: a redox proteomics view into the Alzheimer disease brain. , 2013, Free radical biology & medicine.

[2]  Asif Ali,et al.  Physicochemical and immunological studies on 4-hydroxynonenal modified HSA: implications of protein damage by lipid peroxidation products in the etiopathogenesis of SLE. , 2012, Human immunology.

[3]  C. Maier,et al.  A comparative 'bottom up' proteomics strategy for the site-specific identification and quantification of protein modifications by electrophilic lipids. , 2012, Journal of proteomics.

[4]  Baohai Shao Site-specific oxidation of apolipoprotein A-I impairs cholesterol export by ABCA1, a key cardioprotective function of HDL. , 2012, Biochimica et biophysica acta.

[5]  S. Jo,et al.  Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications. , 2011, Journal of proteomics.

[6]  William H. Bisson,et al.  Site-specific proteomic analysis of lipoxidation adducts in cardiac mitochondria reveals chemical diversity of 2-alkenal adduction. , 2011, Journal of proteomics.

[7]  J. Galligan,et al.  Overview of lipid peroxidation products and hepatic protein modification in alcoholic liver disease. , 2011, Chemico-biological interactions.

[8]  R. Pamplona Advanced lipoxidation end-products. , 2011, Chemico-biological interactions.

[9]  A. Katyal,et al.  Modification of mouse A2M B (620–792) and A2M N (168–230) by malondialdehyde and acetaldehyde attenuates the proteinase and TGF‐β1 binding ability of A2MB , 2011, FEBS letters.

[10]  P. Champeil,et al.  Inhibition by 4-hydroxynonenal (HNE) of Ca2+ transport by SERCA1a: low concentrations of HNE open protein-mediated leaks in the membrane. , 2011, Free radical biology & medicine.

[11]  H. Youn,et al.  Malondialdehyde inhibits an AMPK-mediated nuclear translocation and repression activity of ALDH2 in transcription. , 2011, Biochemical and biophysical research communications.

[12]  L. Klassen,et al.  Malondialdehyde-acetaldehyde adduct is the dominant epitope after MDA modification of proteins in atherosclerosis. , 2010, Free radical biology & medicine.

[13]  A. C. Gasparovic,et al.  4-Hydroxynonenal-protein adducts as biomarkers of oxidative stress, lipid peroxidation and oxidative homeostasis , 2010 .

[14]  H. Björkbacka,et al.  Immune responses against aldehyde-modified laminin accelerate atherosclerosis in Apoe-/- mice. , 2010, Atherosclerosis.

[15]  N. Žarković,et al.  Pathological aspects of lipid peroxidation , 2010, Free radical research.

[16]  P. Venskutonis,et al.  Natural and synthetic antioxidants: An updated overview , 2010, Free radical research.

[17]  N. Žarković,et al.  Advances in methods for the determination of biologically relevant lipid peroxidation products , 2010, Free radical research.

[18]  L. Huc,et al.  Chemistry and biochemistry of lipid peroxidation products , 2010, Free radical research.

[19]  F. Regnier,et al.  Proteomic identification of carbonylated proteins and their oxidation sites. , 2010, Journal of proteome research.

[20]  Lihua Jin,et al.  Identification of acrolein-conjugated protein in plasma of patients with brain infarction. , 2010, Biochemical and biophysical research communications.

[21]  N. Žarković,et al.  HNE-protein adducts formation in different pre-carcinogenic stages of hepatitis in LEC rats , 2010, Free radical research.

[22]  N. Žarković,et al.  Lipid peroxidation product acrolein as a predictive biomarker of prostate carcinoma relapse after radical surgery , 2010, Free radical research.

[23]  J. F. Stevens,et al.  Hop proanthocyanidins induce apoptosis, protein carbonylation, and cytoskeleton disorganization in human colorectal adenocarcinoma cells via reactive oxygen species. , 2009, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[24]  N. Seidler,et al.  Trifluoroethanol increases albumin's susceptibility to chemical modification. , 2008, Archives of biochemistry and biophysics.

[25]  Tobias Jung,et al.  The proteasome and its role in the degradation of oxidized proteins , 2008, IUBMB life.

[26]  T. Griffin,et al.  Oxidative Stress and Covalent Modification of Protein with Bioactive Aldehydes* , 2008, Journal of Biological Chemistry.

[27]  Sohei Ito,et al.  Site-specific modification of positively-charged surfaces on human serum albumin by malondialdehyde. , 2008, Biochemical and biophysical research communications.

[28]  J. Papaconstantinou,et al.  Age-related alterations in oxidatively damaged proteins of mouse heart mitochondrial electron transport chain complexes. , 2008, Free radical biology & medicine.

[29]  A. Nègre-Salvayre,et al.  Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors , 2008, British journal of pharmacology.

[30]  J. Rabek,et al.  Age-related increases in oxidatively damaged proteins of mouse kidney mitochondrial electron transport chain complexes. , 2007, Free radical biology & medicine.

[31]  Dean P. Jones,et al.  Reactive aldehyde modification of thioredoxin-1 activates early steps of inflammation and cell adhesion. , 2007, The American journal of pathology.

[32]  Edward H. Smith,et al.  Identification of Anesthetic Binding Sites on Human Serum Albumin Using a Novel Etomidate Photolabel* , 2007, Journal of Biological Chemistry.

[33]  G. Aldini,et al.  Actin Cys374 as a nucleophilic target of α,β-unsaturated aldehydes , 2007 .

[34]  M. Tanito,et al.  Identification of 4-hydroxynonenal-modified retinal proteins induced by photooxidative stress prior to retinal degeneration. , 2006, Free radical biology & medicine.

[35]  G. Aldini,et al.  Mass spectrometric characterization of covalent modification of human serum albumin by 4-hydroxy-trans-2-nonenal. , 2006, Journal of mass spectrometry : JMS.

[36]  D. Ferrington,et al.  Retinal proteins modified by 4-hydroxynonenal: identification of molecular targets. , 2006, Experimental eye research.

[37]  N. Žarković,et al.  Saccharomyces cerevisiae strain expressing a plant fatty acid desaturase produces polyunsaturated fatty acids and is susceptible to oxidative stress induced by lipid peroxidation. , 2006, Free radical biology & medicine.

[38]  N. Žarković,et al.  Enzyme-linked immunosorbent assay for 4-hydroxynonenal–histidine conjugates , 2006, Free radical research.

[39]  Yoshiro Saito,et al.  Lipid peroxidation: mechanisms, inhibition, and biological effects. , 2005, Biochemical and biophysical research communications.

[40]  G. Aldini,et al.  Covalent modification of actin by 4-hydroxy-trans-2-nonenal (HNE): LC-ESI-MS/MS evidence for Cys374 Michael adduction. , 2005, Journal of mass spectrometry : JMS.

[41]  R. S. Sohal,et al.  Aconitase and ATP synthase are targets of malondialdehyde modification and undergo an age-related decrease in activity in mouse heart mitochondria. , 2005, Biochemical and biophysical research communications.

[42]  D. Petersen,et al.  4-Hydroxynonenal regulates 26S proteasomal degradation of alcohol dehydrogenase. , 2004, Free radical biology & medicine.

[43]  L. Klassen,et al.  Malondialdehyde-acetaldehyde haptenated protein binds macrophage scavenger receptor(s) and induces lysosomal damage. , 2004, International immunopharmacology.

[44]  B. Halliwell,et al.  Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? , 2004, British journal of pharmacology.

[45]  J. Rabek,et al.  Oxidatively damaged proteins of heart mitochondrial electron transport complexes. , 2004, Biochimica et biophysica acta.

[46]  D. Butterfield,et al.  4-Hydroxynonenal oxidatively modifies histones: implications for Alzheimer's disease , 2004, Neuroscience Letters.

[47]  N. Žarković 4-hydroxynonenal as a bioactive marker of pathophysiological processes. , 2003, Molecular aspects of medicine.

[48]  A. Nègre-Salvayre,et al.  Oxidized LDL and 4-hydroxynonenal modulate tyrosine kinase receptor activity. , 2003, Molecular aspects of medicine.

[49]  K. Davies,et al.  The proteasomal system and HNE-modified proteins. , 2003, Molecular aspects of medicine.

[50]  K. Uchida,et al.  Serum protein acrolein adducts: utility in detecting oxidant stress in hemodialysis patients and reversal using a vitamin E-bonded hemodialyzer. , 2002, Free radical biology & medicine.

[51]  D. Tuma Role of malondialdehyde-acetaldehyde adducts in liver injury. , 2002, Free radical biology & medicine.

[52]  A. Mooradian,et al.  Malondialdehyde modification of proteins in vitro is enhanced in the presence of acetaldehyde. , 2001, Nutrition.

[53]  N. Žarković,et al.  The carcinostatic and proapoptotic potential of 4-hydroxynonenal in HeLa cells is associated with its conjugation to cellular proteins. , 2001, Anticancer research.

[54]  C. Cross,et al.  Cigarette smoke impairs neutrophil respiratory burst activation by aldehyde-induced thiol modifications. , 2001, Toxicology.

[55]  S. Biswal,et al.  The molecular effects of acrolein. , 2000, Toxicological sciences : an official journal of the Society of Toxicology.

[56]  E. Niki,et al.  Protein-bound acrolein: potential markers for oxidative stress. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[57]  B. Friguet,et al.  Inhibition of the multicatalytic proteinase (proteasome) by 4‐hydroxy‐2‐nonenal cross‐linked protein , 1997, FEBS letters.

[58]  S. L. Hazen,et al.  Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to convert hydroxy-amino acids into glycolaldehyde, 2-hydroxypropanal, and acrolein. A mechanism for the generation of highly reactive alpha-hydroxy and alpha,beta-unsaturated aldehydes by phagocytes at sites of inflammat , 1997, The Journal of clinical investigation.

[59]  H. Esterbauer,et al.  Monoclonal antibodies for detection of 4-hydroxynonenal modified proteins. , 1996, Free radical research.

[60]  B. Friguet,et al.  Chemical characterization of a protein-4-hydroxy-2-nonenal cross-link: immunochemical detection in mitochondria exposed to oxidative stress. , 1996, Archives of biochemistry and biophysics.

[61]  L. Klassen,et al.  Acetaldehyde and malondialdehyde react together to generate distinct protein adducts in the liver during long‐term ethanol administration , 1996, Hepatology.

[62]  E. Stadtman,et al.  Characterization of epitopes recognized by 4-hydroxy-2-nonenal specific antibodies. , 1995, Archives of biochemistry and biophysics.

[63]  C. Catalano,et al.  Inactivation of DNA polymerase alpha-primase by acrolein: loss of activity depends on the DNA substrate. , 1995, Biochemical and Biophysical Research Communications - BBRC.

[64]  N. Porter,et al.  Mechanisms of free radical oxidation of unsaturated lipids , 1995, Lipids.

[65]  R. Rucker,et al.  Chemical modifications of proteins in vivo: selected examples important to cellular regulation. , 1993, The Journal of nutrition.

[66]  H. Esterbauer,et al.  Cytotoxicity and genotoxicity of lipid-oxidation products. , 1993, The American journal of clinical nutrition.

[67]  H. Esterbauer,et al.  Modification of human low-density lipoprotein by the lipid peroxidation product 4-hydroxynonenal. , 1986, Biochimica et biophysica acta.

[68]  H. Kohn,et al.  ON A NEW AEROBIC METABOLITE WHOSE PRODUCTION BY BRAIN IS INHIBITED BY APOMORPHINE, EMETINE, ERGOTAMINE, EPINEPHRINE, AND MENADIONE , 1944 .

[69]  James R. Roede,et al.  Posttranslational modification and regulation of glutamate-cysteine ligase by the α,β-unsaturated aldehyde 4-hydroxy-2-nonenal. , 2011, Free radical biology & medicine.

[70]  M. A. Mandal,et al.  Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells. , 2010, Free radical biology & medicine.

[71]  D. Petersen,et al.  Inhibition of human mitochondrial aldehyde dehydrogenase by 4-hydroxynon-2-enal and 4-oxonon-2-enal. , 2006, Chemical research in toxicology.

[72]  L. Klassen,et al.  Adduction of soluble proteins with malondialdehyde-acetaldehyde (MAA) induces antibody production and enhances T-cell proliferation. , 2002, Alcoholism, clinical and experimental research.

[73]  A. Mooradian,et al.  Glycosylation enhances malondialdehyde binding to proteins. , 1996, Free radical biology & medicine.

[74]  J. Aikens,et al.  Mechanisms and biological relevance of lipid peroxidation initiation. , 1993, Chemical research in toxicology.

[75]  H. Esterbauer,et al.  Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. , 1991, Free radical biology & medicine.

[76]  K. Morgan,et al.  A critical review of the literature on acrolein toxicity. , 1985, Critical reviews in toxicology.