TiCl4-Catalyzed Efficient One-Pot Synthesis of α α-Amino Phosphonates

α-Aminophosphonates are synthesized by three-component condensation of aldehydes, amines, and trimethylphosphite in acetonitrile by using TiCl4 as catalyst. Compared to conventional methods, this new method consistently has advantages, including excellent yields, short reaction times, and mild reaction conditions.

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