Novel insights on thyroid-stimulating hormone receptor signal transduction.
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[1] M. Bünemann,et al. Voltage regulates adrenergic receptor function , 2013, Proceedings of the National Academy of Sciences.
[2] Ulrike Holzgrabe,et al. Molecular alliance-from orthosteric and allosteric ligands to dualsteric/bitopic agonists at G protein coupled receptors. , 2013, Angewandte Chemie.
[3] G. Krause,et al. Extended and Structurally Supported Insights into Extracellular Hormone Binding, Signal Transduction and Organization of the Thyrotropin Receptor , 2012, PloS one.
[4] Titiwat Sungkaworn,et al. Single-molecule analysis of fluorescently labeled G-protein–coupled receptors reveals complexes with distinct dynamics and organization , 2012, Proceedings of the National Academy of Sciences.
[5] Maria F. Sassano,et al. A Pharmacological Organization of G Protein-coupled Receptors , 2012, Nature Methods.
[6] A. Cassio,et al. Current Loss-of-Function Mutations in the Thyrotropin Receptor Gene: When to Investigate, Clinical Effects, and Treatment , 2012, Journal of clinical research in pediatric endocrinology.
[7] S. Sealfon,et al. Identification of Three Residues Essential for 5-Hydroxytryptamine 2A-Metabotropic Glutamate 2 (5-HT2A·mGlu2) Receptor Heteromerization and Its Psychoactive Behavioral Function* , 2012, The Journal of Biological Chemistry.
[8] R. Núñez Miguel,et al. Similarities and differences in interactions of thyroid stimulating and blocking autoantibodies with the TSH receptor. , 2012, Journal of molecular endocrinology.
[9] M. Gershengorn,et al. Update in TSH receptor agonists and antagonists. , 2012, The Journal of clinical endocrinology and metabolism.
[10] M. Niv,et al. Computational and Experimental Analysis of the Transmembrane Domain 4/5 Dimerization Interface of the Serotonin 5-HT1A Receptor , 2012, Molecular Pharmacology.
[11] T. Endo,et al. Dominant Negative Effect of Mutated Thyroid Stimulating Hormone Receptor (P556L) Causes Hypothyroidism in C.RF-Tshrhyt/wild Mice , 2012, PloS one.
[12] C. Tate,et al. Agonist-bound structures of G protein-coupled receptors. , 2012, Current opinion in structural biology.
[13] S. Fukata,et al. A Japanese family with familial nonautoimmune hyperthyroidism with a novel mutation (Asn406Ser) in extracellular domain of thyrotrophin receptor , 2012, Clinical Endocrinology.
[14] B. Raaka,et al. A drug-like antagonist inhibits thyrotropin receptor-mediated stimulation of cAMP production in Graves' orbital fibroblasts. , 2012, Thyroid : official journal of the American Thyroid Association.
[15] Xuliang Jiang,et al. Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor , 2012, Proceedings of the National Academy of Sciences.
[16] R. Stevens,et al. Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions , 2012, Science.
[17] Wei-Chiao Chang,et al. R450H TSH receptor mutation in congenital hypothyroidism in Taiwanese children. , 2012, Clinica chimica acta; international journal of clinical chemistry.
[18] B. Wiesner,et al. The Pseudo Signal Peptide of the Corticotropin-releasing Factor Receptor Type 2A Prevents Receptor Oligomerization* , 2012, The Journal of Biological Chemistry.
[19] F. Gbahou,et al. Human cytomegalovirus-encoded UL33 and UL78 heteromerize with host CCR5 and CXCR4 impairing their HIV coreceptor activity. , 2012, Blood.
[20] Brian K Shoichet,et al. Structure-based drug screening for G-protein-coupled receptors. , 2012, Trends in pharmacological sciences.
[21] Andrea Bortolato,et al. New insights from structural biology into the druggability of G protein-coupled receptors. , 2012, Trends in pharmacological sciences.
[22] Terry J. Smith,et al. Human fibrocytes coexpress thyroglobulin and thyrotropin receptor , 2012, Proceedings of the National Academy of Sciences.
[23] A. IJzerman,et al. Determination of different putative allosteric binding pockets at the lutropin receptor by using diverse drug-like low molecular weight ligands , 2012, Molecular and Cellular Endocrinology.
[24] M. Wheatley,et al. The role of the extracellular loops of the CGRP receptor, a family B GPCR. , 2012, Biochemical Society transactions.
[25] R. Bahn,et al. Autoimmunity and Graves’ Disease , 2012, Clinical pharmacology and therapeutics.
[26] D. Segaloff,et al. Revisiting and questioning functional rescue between dimerized LH receptor mutants. , 2012, Molecular endocrinology.
[27] E. Fliers,et al. Complete inhibition of rhTSH-, Graves' disease IgG-, and M22-induced cAMP production in differentiated orbital fibroblasts by a low-molecular-weight TSHR antagonist. , 2012, The Journal of clinical endocrinology and metabolism.
[28] J. Becker,et al. Identification of residues involved in homodimer formation located within a β-strand region of the N-terminus of a Yeast G protein-coupled receptor , 2012, Journal of receptor and signal transduction research.
[29] Terry J. Smith,et al. Increased expression of TSH receptor by fibrocytes in thyroid-associated ophthalmopathy leads to chemokine production. , 2012, The Journal of clinical endocrinology and metabolism.
[30] V. Mutel,et al. Lateral Allosterism in the Glucagon Receptor Family: Glucagon-Like Peptide 1 Induces G-Protein-Coupled Receptor Heteromer Formation , 2012, Molecular Pharmacology.
[31] B. Trzaskowski,et al. Action of Molecular Switches in GPCRs - Theoretical and Experimental Studies , 2012, Current medicinal chemistry.
[32] Albert C. Pan,et al. Structure and Dynamics of the M3 Muscarinic Acetylcholine Receptor , 2012, Nature.
[33] Hugh Rosen,et al. Crystal Structure of a Lipid G Protein–Coupled Receptor , 2012, Science.
[34] Bryan L. Roth,et al. Structure of the human kappa opioid receptor in complex with JDTic , 2012, Nature.
[35] A. Grüters,et al. New pathogenic thyrotropin receptor mutations decipher differentiated activity switching at a conserved helix 6 motif of family A GPCR. , 2012, The Journal of clinical endocrinology and metabolism.
[36] Z. Liu,et al. Structure-based design in the GPCR target space. , 2012, Current Medicinal Chemistry.
[37] Qiang Zhao,et al. Ice breaking in GPCR structural biology , 2012, Acta Pharmacologica Sinica.
[38] M. Lohse,et al. Persistent cAMP signaling by internalized TSH receptors occurs in thyroid but not in HEK293 cells , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[39] F. Fares,et al. Conversion of TSH heterodimer to a single polypeptide chain increases bioactivity and longevity. , 2012, Endocrinology.
[40] S. Swillens,et al. Evidence for activity-regulated hormone-binding cooperativity across glycoprotein hormone receptor homomers , 2012, Nature Communications.
[41] Xavier Deupi,et al. Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II , 2011, Proceedings of the National Academy of Sciences.
[42] I. Parnas,et al. Depolarization induces a conformational change in the binding site region of the M2 muscarinic receptor , 2011, Proceedings of the National Academy of Sciences.
[43] Francesca Fanelli,et al. Update 1 of: computational modeling approaches to structure-function analysis of G protein-coupled receptors. , 2011, Chemical reviews.
[44] R. Jockers,et al. History and Biological Significance of GPCR Heteromerization in the Neuroendocrine System , 2011, Neuroendocrinology.
[45] Krzysztof Palczewski,et al. The Significance of G Protein-Coupled Receptor Crystallography for Drug Discovery , 2011, Pharmacological Reviews.
[46] Virgil L. Woods,et al. Conformational changes in the G protein Gs induced by the β2 adrenergic receptor , 2011, Nature.
[47] T. Schöneberg,et al. Mutually Opposite Signal Modulation by Hypothalamic Heterodimerization of Ghrelin and Melanocortin-3 Receptors* , 2011, The Journal of Biological Chemistry.
[48] R. Jockers,et al. Heteromerization of human cytomegalovirus encoded chemokine receptors , 2011, Biochemical pharmacology.
[49] S. Filetti,et al. TSH receptor extracellular region mutations in thyroid functioning nodules: further evidence for the functional role of this region in the receptor activation , 2011, Endocrine.
[50] J. Simms,et al. Lifting the lid on GPCRs: the role of extracellular loops , 2011, British journal of pharmacology.
[51] S. Mueller,et al. The hinge region of the TSH receptor stabilizes ligand binding and determines different signaling profiles of human and bovine TSH. , 2011, Endocrinology.
[52] A. Grüters,et al. Molecular description of non-autoimmune hyperthyroidism at a neonate caused by a new thyrotropin receptor germline mutation , 2011, Thyroid research.
[53] Xavier Deupi,et al. Structural insights into agonist-induced activation of G-protein-coupled receptors. , 2011, Current opinion in structural biology.
[54] Avner Schlessinger,et al. Ligand Discovery from a Dopamine D3 Receptor Homology Model and Crystal Structure , 2011, Nature chemical biology.
[55] S. Rasmussen,et al. Crystal Structure of the β2Adrenergic Receptor-Gs protein complex , 2011, Nature.
[56] M. Gershengorn,et al. Occupancy of both sites on the thyrotropin (TSH) receptor dimer is necessary for phosphoinositide signaling , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[57] Tong Liu,et al. Structural Basis of M3 Muscarinic Receptor Dimer/Oligomer Formation* , 2011, The Journal of Biological Chemistry.
[58] Keisuke Nagasaki,et al. Nonclassic TSH resistance: TSHR mutation carriers with discrepantly high thyroidal iodine uptake. , 2011, The Journal of clinical endocrinology and metabolism.
[59] H. Hamm,et al. Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit , 2011, Proceedings of the National Academy of Sciences.
[60] Catherine L. Worth,et al. From Molecular Details of the Interplay between Transmembrane Helices of the Thyrotropin Receptor to General Aspects of Signal Transduction in Family A G-protein-coupled Receptors (GPCRs)* , 2011, The Journal of Biological Chemistry.
[61] Y. Shichida,et al. Comparative Fluorescence Resonance Energy Transfer Analysis of Metabotropic Glutamate Receptors , 2011, The Journal of Biological Chemistry.
[62] R. Paschke,et al. Defining Structural and Functional Dimensions of the Extracellular Thyrotropin Receptor Region* , 2011, The Journal of Biological Chemistry.
[63] B. Rapoport,et al. Relationship between thyrotropin receptor hinge region proteolytic posttranslational modification and receptor physiological function. , 2011, Molecular endocrinology.
[64] R. Stevens,et al. Structure of an Agonist-Bound Human A2A Adenosine Receptor , 2011, Science.
[65] M. Tristani-Firouzi,et al. Conformational changes in the M2 muscarinic receptor induced by membrane voltage and agonist binding , 2011, The Journal of physiology.
[66] R. Núñez Miguel,et al. Crystal structure of the TSH receptor (TSHR) bound to a blocking-type TSHR autoantibody. , 2011, Journal of molecular endocrinology.
[67] Francesca Fanelli,et al. Conserved amino acids participate in the structure networks deputed to intramolecular communication in the lutropin receptor , 2011, Cellular and Molecular Life Sciences.
[68] Gebhard F. X. Schertler,et al. The structural basis of agonist-induced activation in constitutively active rhodopsin , 2011, Nature.
[69] R. Paschke,et al. Shared sporadic and somatic thyrotropin receptor mutations display more active in vitro activities than familial thyrotropin receptor mutations. , 2011, Thyroid : official journal of the American Thyroid Association.
[70] S. Costagliola,et al. G protein-coupled receptors: mutations and endocrine diseases , 2011, Nature Reviews Endocrinology.
[71] Jörg D. Wichard,et al. Chemogenomic Analysis of G-Protein Coupled Receptors and Their Ligands Deciphers Locks and Keys Governing Diverse Aspects of Signalling , 2011, PloS one.
[72] G. Krause,et al. Research resource: Update and extension of a glycoprotein hormone receptors web application. , 2011, Molecular endocrinology.
[73] J. Veenstra,et al. Neuroendocrine cells in Drosophila melanogaster producing GPA2/GPB5, a hormone with homology to LH, FSH and TSH. , 2011, General and comparative endocrinology.
[74] G. Napolitano,et al. A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor. , 2011, The Journal of clinical endocrinology and metabolism.
[75] T. Schöneberg,et al. Evolution of GPCR: Change and continuity , 2011, Molecular and Cellular Endocrinology.
[76] I. Parnas,et al. A novel fast mechanism for GPCR-mediated signal transduction—control of neurotransmitter release , 2011, The Journal of cell biology.
[77] B. Rapoport,et al. Evidence That the Thyroid-stimulating Hormone (TSH) Receptor Transmembrane Domain Influences Kinetics of TSH Binding to the Receptor Ectodomain* , 2010, The Journal of Biological Chemistry.
[78] Christopher G. Tate,et al. The structural basis for agonist and partial agonist action on a β1-adrenergic receptor , 2010, Nature.
[79] Graeme Milligan,et al. Allostery at G Protein-Coupled Receptor Homo- and Heteromers: Uncharted Pharmacological Landscapes , 2010, Pharmacological Reviews.
[80] R. Abagyan,et al. Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists , 2010, Science.
[81] A. Miyauchi,et al. Subclinical nonautoimmune hyperthyroidism in a family segregates with a thyrotropin receptor mutation with weakly increased constitutive activity. , 2010, Thyroid : official journal of the American Thyroid Association.
[82] S. Rasmussen,et al. Structure of a nanobody-stabilized active state of the β2 adrenoceptor , 2010, Nature.
[83] Michael R. Kendall,et al. Novel TSHR mutations in consanguineous families with congenital nongoitrous hypothyroidism , 2010, Clinical endocrinology.
[84] T. Ando,et al. Neutral antibodies to the TSH receptor are present in Graves' disease and regulate selective signaling cascades. , 2010, Endocrinology.
[85] R. Latif,et al. Subunit interactions influence TSHR multimerization. , 2010, Molecular endocrinology.
[86] J. Bogerd,et al. Functional Differences of Invariant and Highly Conserved Residues in the Extracellular Domain of the Glycoprotein Hormone Receptors* , 2010, The Journal of Biological Chemistry.
[87] F. Ciruela,et al. Lighting up multiprotein complexes: lessons from GPCR oligomerization. , 2010, Trends in biotechnology.
[88] J. Javitch,et al. Time-resolved FRET between GPCR ligands reveals oligomers in native tissues. , 2010, Nature chemical biology.
[89] A. Grüters,et al. A new phenotype of nongoitrous and nonautoimmune hyperthyroidism caused by a heterozygous thyrotropin receptor mutation in transmembrane helix 6. , 2010, The Journal of clinical endocrinology and metabolism.
[90] M. Stan,et al. Risk factors for development or deterioration of Graves' ophthalmopathy. , 2010, Thyroid : official journal of the American Thyroid Association.
[91] George Khelashvili,et al. GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base , 2010, Bioinform..
[92] J. Wess,et al. Structural basis of G protein-coupled receptor-G protein interactions. , 2010, Nature chemical biology.
[93] Gerd Krause,et al. Signaling‐sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[94] D. Libri,et al. Genetics and phenomics of hypothyroidism due to TSH resistance , 2010, Molecular and Cellular Endocrinology.
[95] E. Fliers,et al. Transient hypothyroxinemia in juvenile glycoprotein hormone subunit B5 knock-out mice , 2010, Molecular and Cellular Endocrinology.
[96] H. Biebermann,et al. Genetic defects, thyroid growth and malfunctions of the TSHR in pediatric patients. , 2010, Frontiers in bioscience.
[97] Gerd Krause,et al. An interactive web‐tool for molecular analyses links naturally occurring mutation data with three‐dimensional structures of the rhodopsin‐like glycoprotein hormone receptors , 2010, Human mutation.
[98] Y. Ramot,et al. Thyroid-stimulating hormone, a novel, locally produced modulator of human epidermal functions, is regulated by thyrotropin-releasing hormone and thyroid hormones. , 2010, Endocrinology.
[99] N. Lambert. GPCR Dimers Fall Apart , 2010, Science Signaling.
[100] K. Lindblad-Toh,et al. Whole-genome resequencing reveals loci under selection during chicken domestication , 2010, Nature.
[101] R. Paschke,et al. Principles and Determinants of G-Protein Coupling by the Rhodopsin-Like Thyrotropin Receptor , 2010, PloS one.
[102] L. Devi,et al. Receptor heteromerization and drug discovery. , 2010, Trends in pharmacological sciences.
[103] R. Latif,et al. A Tyrosine Residue on the TSH Receptor Stabilizes Multimer Formation , 2010, PloS one.
[104] T. Hébert,et al. Structural determinants underlying constitutive dimerization of unoccupied human follitropin receptors. , 2010, Cellular signalling.
[105] M. Lohse. Dimerization in GPCR mobility and signaling. , 2010, Current opinion in pharmacology.
[106] H. Parnas,et al. New Mechanism for Voltage Induced Charge Movement Revealed in GPCRs - Theory and Experiments , 2010, PloS one.
[107] B. Horsthemke,et al. An unbalanced translocation unmasks a recessive mutation in the follicle-stimulating hormone receptor (FSHR) gene and causes FSH resistance , 2010, European Journal of Human Genetics.
[108] Nafis Rahman,et al. Rescue of defective G protein–coupled receptor function in vivo by intermolecular cooperation , 2010, Proceedings of the National Academy of Sciences.
[109] P. Morgan,et al. Effect of Photoperiod on the Thyroid‐Stimulating Hormone Neuroendocrine System in the European Hamster (Cricetus cricetus) , 2010, Journal of neuroendocrinology.
[110] Sheng-Hsiang Li,et al. Thyrostimulin, but Not Thyroid-stimulating Hormone (TSH), Acts as a Paracrine Regulator to Activate the TSH Receptor in Mammalian Ovary* , 2009, The Journal of Biological Chemistry.
[111] R. Latif,et al. TSH receptor autoantibodies. , 2009, Autoimmunity reviews.
[112] Stefano Costanzi,et al. Rhodopsin and the others: a historical perspective on structural studies of G protein-coupled receptors. , 2009, Current pharmaceutical design.
[113] L. Pardo,et al. Ligand-specific regulation of the extracellular surface of a G protein coupled receptor , 2009, Nature.
[114] P. Scheerer,et al. A G protein-coupled receptor at work: the rhodopsin model. , 2009, Trends in biochemical sciences.
[115] B. Raaka,et al. Human TSH receptor ligands as pharmacological probes with potential clinical application , 2009, Expert review of endocrinology & metabolism.
[116] Catherine L. Worth,et al. Comparative Sequence and Structural Analyses of G-Protein-Coupled Receptor Crystal Structures and Implications for Molecular Models , 2009, PloS one.
[117] Steven O. Smith,et al. Multiple switches in G protein-coupled receptor activation. , 2009, Trends in pharmacological sciences.
[118] A. Radu,et al. The cleavage of thyroid‐stimulating hormone receptor is dependent on cell–cell contacts and regulates the hormonal stimulation of phospholipase c , 2009, Journal of cellular and molecular medicine.
[119] C. Tate,et al. Engineering G protein-coupled receptors to facilitate their structure determination. , 2009, Current opinion in structural biology.
[120] S. Bertrand,et al. Distinct expression patterns of glycoprotein hormone-alpha2 and -beta5 in a basal chordate suggest independent developmental functions. , 2009, Endocrinology.
[121] B. Raaka,et al. Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice , 2009, Proceedings of the National Academy of Sciences.
[122] W. Göpel,et al. The gene for the thyrotropin receptor (TSHR) as a candidate gene for congenital hypothyroidism with thyroid dysgenesis , 2009, Experimental and clinical endocrinology & diabetes.
[123] Patrick Scheerer,et al. Structural and kinetic modeling of an activating helix switch in the rhodopsin-transducin interface , 2009, Proceedings of the National Academy of Sciences.
[124] Xavier Deupi,et al. The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex , 2009, Proceedings of the National Academy of Sciences.
[125] M. Zaidi,et al. The thyroid-stimulating hormone receptor: impact of thyroid-stimulating hormone and thyroid-stimulating hormone receptor antibodies on multimerization, cleavage, and signaling. , 2009, Endocrinology and metabolism clinics of North America.
[126] H. Togari,et al. Longitudinal Evaluation of Patients with a Homozygous R450H Mutation of the TSH Receptor Gene , 2009, Hormone Research in Paediatrics.
[127] Thomas M Frimurer,et al. Ligand binding and micro-switches in 7TM receptor structures. , 2009, Trends in pharmacological sciences.
[128] S. Refetoff,et al. Loss-of-function mutations in the thyrotropin receptor gene as a major determinant of hyperthyrotropinemia in a consanguineous community. , 2009, The Journal of clinical endocrinology and metabolism.
[129] R. N. Miguel,et al. Thyroid stimulating autoantibody M22 mimics TSH binding to the TSH receptor leucine rich domain: a comparative structural study of protein-protein interactions. , 2009, Journal of molecular endocrinology.
[130] R. Paschke,et al. The Superagonistic Activity of Bovine Thyroid-stimulating Hormone (TSH) and the Human TR1401 TSH Analog Is Determined by Specific Amino Acids in the Hinge Region of the Human TSH Receptor* , 2009, The Journal of Biological Chemistry.
[131] G. Krause,et al. Thyrotropin and homologous glycoprotein hormone receptors: structural and functional aspects of extracellular signaling mechanisms. , 2009, Endocrine reviews.
[132] J. Wade,et al. Dimerization and Negative Cooperativity in the Relaxin Family Peptide Receptors , 2009, Annals of the New York Academy of Sciences.
[133] T. Hébert,et al. Bioluminescence Resonance Energy Transfer Studies Reveal Constitutive Dimerization of the Human Lutropin Receptor and a Lack of Correlation between Receptor Activation and the Propensity for Dimerization* , 2009, Journal of Biological Chemistry.
[134] B. Rapoport,et al. Evidence that shed thyrotropin receptor A subunits drive affinity maturation of autoantibodies causing Graves' disease. , 2009, The Journal of clinical endocrinology and metabolism.
[135] K. Palczewski,et al. Comparative Analysis of GPCR Crystal Structures † , 2009, Photochemistry and photobiology.
[136] M. Gershengorn,et al. Two Arginine-Glutamate Ionic Locks Near the Extracellular Surface of FFAR1 Gate Receptor Activation* , 2009, Journal of Biological Chemistry.
[137] M. Polak,et al. An inactivating mutation within the first extracellular loop of the thyrotropin receptor impedes normal posttranslational maturation of the extracellular domain. , 2009, Endocrinology.
[138] Viktor Hornak,et al. Helix Movement is Coupled to Displacement of the Second Extracellular Loop in Rhodopsin Activation , 2009, Nature Structural &Molecular Biology.
[139] R. Dighe,et al. Critical Involvement of the Hinge Region of the Follicle-stimulating Hormone Receptor in the Activation of the Receptor* , 2009, Journal of Biological Chemistry.
[140] Raymond C Stevens,et al. Discovery of new GPCR biology: one receptor structure at a time. , 2009, Structure.
[141] Sun Li,et al. Effects of mutations involving cysteine residues distal to the S281HCC motif at the C-terminus on the functional characteristics of a truncated ectodomain-only thyrotropin receptor anchored on glycosylphosphatidyl-inositol. , 2008, Thyroid : official journal of the American Thyroid Association.
[142] H. Ono,et al. Involvement of thyrotropin in photoperiodic signal transduction in mice , 2008, Proceedings of the National Academy of Sciences.
[143] R. Paschke,et al. Preferences of transmembrane helices for cooperative amplification of Gαs and Gαq signaling of the thyrotropin receptor , 2008, Cellular and Molecular Life Sciences.
[144] R. Paschke,et al. Molecular and structural effects of inverse agonistic mutations on signaling of the thyrotropin receptor – a basally active GPCR , 2008, Cellular and Molecular Life Sciences.
[145] L. Pardo,et al. The cloned equine thyrotropin receptor is hypersensitive to human chorionic gonadotropin; identification of three residues in the extracellular domain involved in ligand specificity. , 2008, Endocrinology.
[146] Oliver P. Ernst,et al. Crystal structure of opsin in its G-protein-interacting conformation , 2008, Nature.
[147] A. Themmen,et al. Asp330 and Tyr331 in the C-terminal Cysteine-rich Region of the Luteinizing Hormone Receptor Are Key Residues in Hormone-induced Receptor Activation* , 2008, Journal of Biological Chemistry.
[148] Marta Filizola,et al. Dopamine D2 receptors form higher order oligomers at physiological expression levels , 2008, The EMBO journal.
[149] T. Blundell,et al. FSH and TSH binding to their respective receptors: similarities, differences and implication for glycoprotein hormone specificity. , 2008, Journal of molecular endocrinology.
[150] Gerhard Hummer,et al. Atomistic insights into rhodopsin activation from a dynamic model. , 2008, Journal of the American Chemical Society.
[151] J. Fustin,et al. Ancestral TSH Mechanism Signals Summer in a Photoperiodic Mammal , 2008, Current Biology.
[152] R. Paschke,et al. Evidence for cooperative signal triggering at the extracellular loops of the TSH receptor , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[153] I. S. Gurung,et al. A role for membrane potential in regulating GPCRs? , 2008, Trends in pharmacological sciences.
[154] T. Gudermann,et al. G13-dependent Activation of MAPK by Thyrotropin* , 2008, Journal of Biological Chemistry.
[155] Patrick Scheerer,et al. Crystal structure of the ligand-free G-protein-coupled receptor opsin , 2008, Nature.
[156] W. Hendrickson,et al. Comparative structural analysis of the binding domain of follicle stimulating hormone receptor , 2008, Proteins.
[157] R. Paschke,et al. Extended Hormone Binding Site of the Human Thyroid Stimulating Hormone Receptor , 2008, Journal of Biological Chemistry.
[158] Jan Kelder,et al. A signaling-selective, nanomolar potent allosteric low molecular weight agonist for the human luteinizing hormone receptor , 2008, Naunyn-Schmiedeberg's Archives of Pharmacology.
[159] I S Gurung,et al. Novel consequences of voltage‐dependence to G‐protein‐coupled P2Y1 receptors , 2008, British journal of pharmacology.
[160] A. Smrcka. G protein βγ subunits: Central mediators of G protein-coupled receptor signaling , 2008, Cellular and Molecular Life Sciences.
[161] G. Schertler. Signal transduction: The rhodopsin story continued , 2008, Nature.
[162] B. Rapoport,et al. The thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction. , 2008, Molecular endocrinology.
[163] B. Raaka,et al. Understanding the structural and functional differences between mouse thyrotropin‐releasing hormone receptors 1 and 2 , 2008, Proteins.
[164] L. Pardo,et al. The specificity of binding of glycoprotein hormones to their receptors , 2008, Cellular and Molecular Life Sciences.
[165] C. Holmes,et al. Differing pharmacological activities of thiazolidinone analogs at the FSH receptor. , 2008, Biochemical and biophysical research communications.
[166] Francesca Fanelli,et al. An intracellular loop (IL2) residue confers different basal constitutive activities to the human lutropin receptor and human thyrotropin receptor through structural communication between IL2 and helix 6, via helix 3. , 2008, Endocrinology.
[167] H. Ueda,et al. Thyrotrophin in the pars tuberalis triggers photoperiodic response , 2008, Nature.
[168] Wayne A Hendrickson,et al. Ligand sensitivity in dimeric associations of the serotonin 5HT2c receptor , 2008, EMBO reports.
[169] Krzysztof Palczewski,et al. Efficient Coupling of Transducin to Monomeric Rhodopsin in a Phospholipid Bilayer* , 2008, Journal of Biological Chemistry.
[170] K. Lorenz,et al. Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling. , 2008, Nature chemical biology.
[171] B. Kobilka,et al. New G-protein-coupled receptor crystal structures: insights and limitations. , 2008, Trends in pharmacological sciences.
[172] S. Ellard,et al. A family with a novel TSH receptor activating germline mutation (p.Ala485Val) , 2008, European Journal of Pediatrics.
[173] T. Takano,et al. A novel thyrotropin receptor germline mutation (Asp617Tyr) causing hereditary hyperthyroidism. , 2007, Endocrine journal.
[174] Xin-Yun Huang,et al. When a G protein-coupled receptor does not couple to a G protein. , 2007, Molecular bioSystems.
[175] B. Rapoport,et al. The thyrotropin receptor in Graves' disease. , 2007, Thyroid : official journal of the American Thyroid Association.
[176] S. Tunaru,et al. Thyrocyte-specific Gq/G11 deficiency impairs thyroid function and prevents goiter development. , 2007, The Journal of clinical investigation.
[177] L. Puskás,et al. Cleavage of the human thyrotropin receptor by ADAM10 is regulated by thyrotropin , 2007, Journal of molecular recognition : JMR.
[178] Xavier Deupi,et al. Conformational complexity of G-protein-coupled receptors. , 2007, Trends in pharmacological sciences.
[179] J. Simms,et al. Extracellular loops and ligand binding to a subfamily of Family A G-protein-coupled receptors. , 2007, Biochemical Society transactions.
[180] Joseph Shiloach,et al. Dimerization of the class A G protein-coupled neurotensin receptor NTS1 alters G protein interaction , 2007, Proceedings of the National Academy of Sciences.
[181] S. Refetoff,et al. A familial thyrotropin (TSH) receptor mutation provides in vivo evidence that the inositol phosphates/Ca2+ cascade mediates TSH action on thyroid hormone synthesis. , 2007, The Journal of clinical endocrinology and metabolism.
[182] P. Santisteban,et al. TSH signalling and cancer. , 2007, Arquivos brasileiros de endocrinologia e metabologia.
[183] T. Blundell,et al. Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody. , 2007, Thyroid : official journal of the American Thyroid Association.
[184] Richard N. Zare,et al. A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein , 2007, Proceedings of the National Academy of Sciences.
[185] J. Gutkind,et al. G-protein-coupled receptors and cancer , 2007, Nature Reviews Cancer.
[186] G. Kleinau,et al. Implications for molecular mechanisms of glycoprotein hormone receptors using a new sequence-structure-function analysis resource. , 2007, Molecular Endocrinology.
[187] T. Gudermann,et al. A conformational contribution of the luteinizing hormone-receptor ectodomain to receptor activation. , 2007, Journal of molecular endocrinology.
[188] L. Persani,et al. Technology Insight: modern methods to monitor protein–protein interactions reveal functional TSH receptor oligomerization , 2007, Nature Clinical Practice Endocrinology &Metabolism.
[189] Rob Leurs,et al. Pharmacogenomic and structural analysis of constitutive g protein-coupled receptor activity. , 2007, Annual review of pharmacology and toxicology.
[190] R. Paschke,et al. Contacts between Extracellular Loop Two and Transmembrane Helix Six Determine Basal Activity of the Thyroid-stimulating Hormone Receptor* , 2007, Journal of Biological Chemistry.
[191] W. Hendrickson,et al. Assembly and structural characterization of an authentic complex between human follicle stimulating hormone and a hormone-binding ectodomain of its receptor , 2007, Molecular and Cellular Endocrinology.
[192] M. Jeoung,et al. Trans-activation, cis-activation and signal selection of gonadotropin receptors , 2007, Molecular and Cellular Endocrinology.
[193] S. Costagliola,et al. Structural differences in the hinge region of the glycoprotein hormone receptors: evidence from the sulfated tyrosine residues. , 2006, Molecular endocrinology.
[194] Francisco Bezanilla,et al. Movement of ‘gating charge’ is coupled to ligand binding in a G-protein-coupled receptor , 2006, Nature.
[195] R. Paschke,et al. Similar prevalence of somatic TSH receptor and Gsalpha mutations in toxic thyroid nodules in geographical regions with different iodine supply in Turkey. , 2006, European journal of endocrinology.
[196] R. Paschke,et al. Structural determinants for G-protein activation and specificity in the third intracellular loop of the thyroid-stimulating hormone receptor , 2006, Journal of Molecular Medicine.
[197] Ned Van Eps,et al. Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins , 2006, Nature Structural &Molecular Biology.
[198] Philippe Delagrange,et al. The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization , 2006, The EMBO journal.
[199] Gerd Krause,et al. Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns. , 2006, Journal of medicinal chemistry.
[200] R. Horuk,et al. I want a new drug: G-protein-coupled receptors in drug development. , 2006, Drug discovery today.
[201] K. Wawrowsky,et al. Evidence that human thyroid cells express uncleaved, single-chain thyrotropin receptors on their surface. , 2006, Endocrinology.
[202] R. Paschke,et al. A Low Molecular Weight Agonist Signals by Binding to the Transmembrane Domain of Thyroid-stimulating Hormone Receptor (TSHR) and Luteinizing Hormone/Chorionic Gonadotropin Receptor (LHCGR)* , 2006, Journal of Biological Chemistry.
[203] F. Fares. The role of O-linked and N-linked oligosaccharides on the structure-function of glycoprotein hormones: development of agonists and antagonists. , 2006, Biochimica et biophysica acta.
[204] R. Paschke,et al. An aromatic environment in the vicinity of serine 281 is a structural requirement for thyrotropin receptor function. , 2006, Endocrinology.
[205] M. Hoenig,et al. Cloning and sequencing of feline thyrotropin (fTSH): heterodimeric and yoked constructs. , 2006, Domestic animal endocrinology.
[206] M. Hoenig,et al. Expression and purification of feline thyrotropin (fTSH): immunological detection and bioactivity of heterodimeric and yoked glycoproteins. , 2006, Domestic animal endocrinology.
[207] E. Marsh,et al. Absence of Apparent Circadian Rhythms of Gonadotropins and Free α-Subunit in Postmenopausal Women: Evidence for Distinct Regulation Relative to Other Hormonal Rhythms , 2006, Journal of biological rhythms.
[208] J. L. Holloway,et al. A glycoprotein hormone expressed in corticotrophs exhibits unique binding properties on thyroid-stimulating hormone receptor. , 2006, Molecular endocrinology.
[209] A. IJzerman,et al. Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery. , 2006, Trends in pharmacological sciences.
[210] T. Schwartz,et al. Molecular mechanism of 7TM receptor activation--a global toggle switch model. , 2006, Annual review of pharmacology and toxicology.
[211] S. Ho,et al. Cysteine 390 mutation of the TSH receptor modulates its ectodomain as an inverse agonist on the serpentine domain with decrease in basal constitutive activity , 2005, Molecular and Cellular Endocrinology.
[212] T. Kenakin. The physiological significance of constitutive receptor activity , 2005 .
[213] N. Pfarr,et al. Mild congenital primary hypothyroidism in a Turkish family caused by a homozygous missense thyrotropin receptor (TSHR) gene mutation (A593 V). , 2005, Experimental and clinical endocrinology & diabetes.
[214] Marta Filizola,et al. Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[215] Didier Rognan,et al. A chemogenomic analysis of the transmembrane binding cavity of human G‐protein‐coupled receptors , 2005, Proteins.
[216] Davide Calebiro,et al. Intracellular entrapment of wild-type TSH receptor by oligomerization with mutants linked to dominant TSH resistance. , 2005, Human molecular genetics.
[217] R. Paschke,et al. Novel thyrotropin receptor germline mutation (Ile568Val) in a Saxonian family with hereditary nonautoimmune hyperthyroidism. , 2005, Thyroid : official journal of the American Thyroid Association.
[218] G. Krause,et al. TSH receptor mutation V509A causes familial hyperthyroidism by release of interhelical constraints between transmembrane helices TMH3 and TMH5. , 2005, The Journal of endocrinology.
[219] P. Kelly,et al. Zero-length cross-linking reveals that tight interactions between the extracellular and transmembrane domains of the luteinizing hormone receptor persist during receptor activation. , 2005, Molecular endocrinology.
[220] Rauf Latif,et al. Thyrotropin receptor-associated diseases: from adenomata to Graves disease. , 2005, The Journal of clinical investigation.
[221] L. Tatò,et al. Thyrotropin receptor gene mutations and TSH resistance: variable expressivity in the heterozygotes , 2005, Clinical endocrinology.
[222] V. Hornak,et al. Comparison of class A and D G protein-coupled receptors: common features in structure and activation. , 2005, Biochemistry.
[223] S. Swillens,et al. Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity , 2005, The EMBO journal.
[224] Sadashiva S Karnik,et al. Multiple Signaling States of G-Protein-Coupled Receptors , 2005, Pharmacological Reviews.
[225] F. Fares,et al. Human thyrotropin (TSH) variants designed by site-directed mutagenesis block TSH activity in vitro and in vivo. , 2005, Endocrinology.
[226] J. Tyndall,et al. GPCR agonists and antagonists in the clinic. , 2005, Medicinal chemistry (Shariqah (United Arab Emirates)).
[227] H. Schiöth,et al. The Repertoire of G-Protein–Coupled Receptors in Fully Sequenced Genomes , 2005, Molecular Pharmacology.
[228] Leonardo Pardo,et al. An Activation Switch in the Rhodopsin Family of G Protein-coupled Receptors , 2005, Journal of Biological Chemistry.
[229] Jae-Il Park,et al. Conservation of the heterodimeric glycoprotein hormone subunit family proteins and the LGR signaling system from nematodes to humans , 2005, Endocrine.
[230] R. Paschke,et al. Interactions between the extracellular domain and the extracellular loops as well as the 6th transmembrane domain are necessary for TSH receptor activation. , 2005, European journal of endocrinology.
[231] C. Hague,et al. Heterodimerization with β2-Adrenergic Receptors Promotes Surface Expression and Functional Activity of α1D-Adrenergic Receptors , 2005, Journal of Pharmacology and Experimental Therapeutics.
[232] B. Kieffer,et al. The second extracellular loop: a damper for G protein–coupled receptors? , 2005, Nature Structural &Molecular Biology.
[233] V. Garcia-Campayo,et al. A Single-Chain Tetradomain Glycoprotein Hormone Analog Elicits Multiple Hormone Activities In Vivo1 , 2005, Biology of reproduction.
[234] Wayne A. Hendrickson,et al. Structure of human follicle-stimulating hormone in complex with its receptor , 2005, Nature.
[235] C. Gachet,et al. Direct Voltage Control of Signaling via P2Y1 and Other Gαq-coupled Receptors* , 2005, Journal of Biological Chemistry.
[236] R. Paschke,et al. Identification of a Novel Epitope in the Thyroid-stimulating Hormone Receptor Ectodomain Acting as Intramolecular Signaling Interface*[boxs] , 2004, Journal of Biological Chemistry.
[237] Katrin Sangkuhl,et al. Mutant G-protein-coupled receptors as a cause of human diseases. , 2004, Pharmacology & therapeutics.
[238] T. Nogimori,et al. Distribution of thyrostimulin in the rat: an immunohistochemical study. , 2004, Endocrine regulations.
[239] L. Limbird. The receptor concept: a continuing evolution. , 2004, Molecular interventions.
[240] G. Milligan,et al. Multiple Interactions between Transmembrane Helices Generate the Oligomeric α1b-Adrenoceptor , 2004, Molecular Pharmacology.
[241] A. Grüters,et al. Molecular genetic defects in congenital hypothyroidism. , 2004, European journal of endocrinology.
[242] B. Conklin,et al. Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans. , 2004, The Journal of clinical investigation.
[243] L. Pardo,et al. Modulation of ligand selectivity associated with activation of the transmembrane region of the human follitropin receptor. , 2004, Molecular endocrinology.
[244] S. Costagliola,et al. Activating mutations of TSH receptor. , 2004, Annales d'endocrinologie.
[245] Kurt Kristiansen,et al. Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function. , 2004, Pharmacology & therapeutics.
[246] D. Puett,et al. Human α-subunit analogs act as partial agonists to the thyroid-stimulating hormone receptor , 2004, Endocrine.
[247] M. Jeoung,et al. Trans-activation of mutant follicle-stimulating hormone receptors selectively generates only one of two hormone signals. , 2004, Molecular endocrinology.
[248] L. Pardo,et al. A molecular dissection of the glycoprotein hormone receptors. , 2004, Trends in biochemical sciences.
[249] Duan Yang,et al. The evolution of transmembrane helix kinks and the structural diversity of G protein-coupled receptors. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[250] Alfonso Valencia,et al. Identification of amino acid residues crucial for chemokine receptor dimerization , 2004, Nature Immunology.
[251] Masakatsu Kamiya,et al. Structural principles of leucine‐rich repeat (LRR) proteins , 2003, Proteins.
[252] Anita Preininger,et al. Insights into G protein structure, function, and regulation. , 2003, Endocrine reviews.
[253] L. Moeller,et al. Hypothyroidism in thyroid transcription factor 1 haploinsufficiency is caused by reduced expression of the thyroid-stimulating hormone receptor. , 2003, Molecular endocrinology.
[254] S. Swillens,et al. Kinetics of thyrotropin-stimulating hormone (TSH) and thyroid-stimulating antibody binding and action on the TSH receptor in intact TSH receptor-expressing CHO cells. , 2003, The Journal of clinical endocrinology and metabolism.
[255] B. Rapoport,et al. Evidence that the C terminus of the A subunit suppresses thyrotropin receptor constitutive activity. , 2003, Endocrinology.
[256] N. Harii,et al. Thyrotropin Receptor Autoantibodies (TSHRAbs): Epitopes, Origins and Clinical Significance , 2003, Autoimmunity.
[257] M. Misrahi,et al. Role of cleavage and shedding in human thyrotropin receptor function and trafficking. , 2003, European journal of biochemistry.
[258] R. Paschke,et al. Biological activity of activating thyroid-stimulating hormone receptor mutants depends on the cellular context. , 2003, Endocrinology.
[259] F. Savagner,et al. A chorionic gonadotropin-sensitive mutation in the follicle-stimulating hormone receptor as a cause of familial gestational spontaneous ovarian hyperstimulation syndrome. , 2003, The New England journal of medicine.
[260] Yuji Nagayama,et al. The thyrotropin receptor autoantigen in Graves disease is the culprit as well as the victim. , 2003, The Journal of clinical investigation.
[261] L. Pardo,et al. Glycoprotein hormone receptors: determinants in leucine‐rich repeats responsible for ligand specificity , 2003, The EMBO journal.
[262] H. Schiöth,et al. The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. , 2003, Molecular pharmacology.
[263] Philippe Manivet,et al. Identification of the binding sites and selectivity of sarpogrelate, a novel 5-HT2 antagonist, to human 5-HT2A, 5-HT2B and 5-HT2C receptor subtypes by molecular modeling. , 2003, Life sciences.
[264] T. Maruo,et al. Activation of the luteinizing hormone receptor in the extracellular domain , 2003, Molecular and Cellular Endocrinology.
[265] B. Rapoport,et al. Targeted restoration of cleavage in a noncleaving thyrotropin receptor demonstrates that cleavage is insufficient to enhance ligand-independent activity. , 2003, Endocrinology.
[266] B. Knudsen,et al. Evolution of the thyrotropin receptor: a G protein coupled receptor with an intrinsic capacity to dimerize. , 2003, Molecular genetics and metabolism.
[267] F. Fanelli,et al. Constitutively active G protein-coupled receptor mutants: implications on receptor function and drug action. , 2003, Assay and drug development technologies.
[268] R. Paschke,et al. Functional significance of the thyrotropin receptor germline polymorphism D727E. , 2003, Biochemical and biophysical research communications.
[269] Stephen K.-F. Wong,et al. G Protein Selectivity Is Regulated by Multiple Intracellular Regions of GPCRs , 2003, Neurosignals.
[270] K. Sangkuhl,et al. Structural Requirements for Mutational Lutropin/Choriogonadotropin Receptor Activation* , 2002, The Journal of Biological Chemistry.
[271] Ulrik Gether,et al. Structural basis for activation of G-protein-coupled receptors. , 2002, Pharmacology & toxicology.
[272] R. Latif,et al. Ligand-dependent Inhibition of Oligomerization at the Human Thyrotropin Receptor* , 2002, The Journal of Biological Chemistry.
[273] P. Mithbaokar,et al. Role of the thyroid-stimulating hormone receptor signaling in development and differentiation of the thyroid gland , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[274] D. Puett,et al. Differential responses of an invariant region in the ectodomain of three glycoprotein hormone receptors to mutagenesis and assay conditions , 2002, Endocrine.
[275] V. Garcia-Campayo,et al. Thyrotropin, follitropin, and chorionic gonadotropin expressed as a single multifunctional unit reveal remarkable permissiveness in receptor-ligand interactions. , 2002, Endocrinology.
[276] P. Corvol,et al. Lessons from constitutively active mutants of G protein-coupled receptors , 2002, Trends in Endocrinology & Metabolism.
[277] Susan R. George,et al. G-Protein-coupled receptor oligomerization and its potential for drug discovery , 2002, Nature Reviews Drug Discovery.
[278] R. Seifert,et al. Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors , 2002, Naunyn-Schmiedeberg's Archives of Pharmacology.
[279] A. Hopkins,et al. The druggable genome , 2002, Nature Reviews Drug Discovery.
[280] D. Segaloff,et al. Constitutive activation of the LH receptor is associated with an alteration in the conformation of the ectodomain , 2002, Molecular and Cellular Endocrinology.
[281] Terry Davies,et al. The TSH receptor reveals itself. , 2002, The Journal of clinical investigation.
[282] S. Hsu,et al. Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5. , 2002, Molecular endocrinology.
[283] T. Kenakin,et al. G Protein-Coupled Receptor Allosterism and Complexing , 2002, Pharmacological Reviews.
[284] E. Milgrom,et al. TSH receptor interaction with the extracellular matrix: role on constitutive activity and sensitivity to hormonal stimulation. , 2002, Molecular endocrinology.
[285] S. Assmann. Heterotrimeric and Unconventional GTP Binding Proteins in Plant Cell Signaling Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.001792. , 2002, The Plant Cell Online.
[286] L. Pardo,et al. A conserved Asn in TM7 of the thyrotropin receptor is a common requirement for activation by both mutations and its natural agonist , 2002, FEBS letters.
[287] S. Costagliola,et al. Activation of the cAMP pathway by the TSH receptor involves switching of the ectodomain from a tethered inverse agonist to an agonist. , 2002, Molecular endocrinology.
[288] B. Weintraub,et al. Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships. , 2002, Physiological reviews.
[289] S. Costagliola,et al. Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors , 2002, The EMBO journal.
[290] T. Akamizu. Antithyrotropin receptor antibody: an update. , 2001, Thyroid : official journal of the American Thyroid Association.
[291] R. Latif,et al. Oligomerization of the Human Thyrotropin Receptor , 2001, The Journal of Biological Chemistry.
[292] A. Rees,et al. The hunchback and its neighbours: proline as an environmental modulator. , 2001, Trends in biochemical sciences.
[293] S. Cornelis,et al. Purification and characterization of a soluble bioactive amino-terminal extracellular domain of the human thyrotropin receptor. , 2001, Biochemistry.
[294] R. Paschke,et al. A free carboxylate oxygen in the side chain of position 674 in transmembrane domain 7 is necessary for TSH receptor activation. , 2001, Molecular endocrinology.
[295] B. Corvilain,et al. Somatic and germline mutations of the TSH receptor and thyroid diseases , 2001, Clinical endocrinology.
[296] S. Costagliola,et al. Effects of mutations involving the highly conserved S281HCC motif in the extracellular domain of the thyrotropin (TSH) receptor on TSH binding and constitutive activity. , 2001, Endocrinology.
[297] A. Morikawa,et al. Novel inactivating missense mutations in the thyrotropin receptor gene in Japanese children with resistance to thyrotropin. , 2001, Thyroid : official journal of the American Thyroid Association.
[298] Jaak Vilo,et al. Prediction of the coupling specificity of G protein coupled receptors to their G proteins , 2001, ISMB.
[299] B. Rapoport,et al. Insight into thyrotropin receptor cleavage by engineering the single polypeptide chain luteinizing hormone receptor into a cleaving, two subunit receptor. , 2001, European journal of biochemistry.
[300] Michel Bouvier,et al. Oligomerization of G-protein-coupled transmitter receptors , 2001, Nature Reviews Neuroscience.
[301] P. Roey,et al. Three-dimensional structure of human follicle-stimulating hormone. , 2001, Molecular endocrinology.
[302] T. Gudermann,et al. Requirement of Specific Intrahelical Interactions for Stabilizing the Inactive Conformation of Glycoprotein Hormone Receptors* , 2000, Journal of Biological Chemistry.
[303] G Vriend,et al. Receptors coupling to G proteins: Is there a signal behind the sequence? , 2000, Proteins.
[304] R. Seifert,et al. Molecular analysis of beta(2)-adrenoceptor coupling to G(s)-, G(i)-, and G(q)-proteins. , 2000, Molecular pharmacology.
[305] B. Rapoport,et al. Evidence that Cleavage of the Thyrotropin Receptor Involves a" Molecular Ruler" Mechanism: Deletion of Amino Acid Residues 305-320 Causes a Spatial Shift in Cleavage Site 1 Independent of Amino Acid Motif. , 2000, Endocrinology.
[306] T. Gudermann,et al. Constitutively activating TSH-receptor mutations as a molecular cause of non-autoimmune hyperthyroidism in childhood , 2000, Langenbeck's Archives of Surgery.
[307] H. Namba,et al. Identification of the sites of asparagine-linked glycosylation on the human thyrotropin receptor and studies on their role in receptor function and expression. , 2000, The Journal of pharmacology and experimental therapeutics.
[308] B. Weintraub,et al. The extracellular domain suppresses constitutive activity of the transmembrane domain of the human TSH receptor: implications for hormone-receptor interaction and antagonist design. , 2000, Endocrinology.
[309] J F Vliegenthart,et al. Effects of the N-linked glycans on the 3D structure of the free alpha-subunit of human chorionic gonadotropin. , 2000, Biochemistry.
[310] U. Gether. Uncovering molecular mechanisms involved in activation of G protein-coupled receptors. , 2000, Endocrine reviews.
[311] C. Cambillau,et al. Crystal structure of a ternary complex between human chorionic gonadotropin (hCG) and two Fv fragments specific for the alpha and beta-subunits. , 1999, Journal of molecular biology.
[312] B. Smith,et al. Analysis of carbohydrate residues on recombinant human thyrotropin receptor. , 1999, The Journal of clinical endocrinology and metabolism.
[313] B. Rapoport,et al. The shed thyrotropin receptor is primarily a carboxyl terminal truncated form of the A subunit, not the entire A subunit , 1999, Molecular and Cellular Endocrinology.
[314] R. Boelens,et al. Solution structure of the a-subunit of human chorionic gonadotropin , 1999 .
[315] E. Milgrom,et al. Sequential Cleavage and Excision of a Segment of the Thyrotropin Receptor Ectodomain* , 1999, The Journal of Biological Chemistry.
[316] J. Parma,et al. Familial gestational hyperthyroidism caused by a mutant thyrotropin receptor hypersensitive to human chorionic gonadotropin. , 1998, The New England journal of medicine.
[317] B. Rapoport,et al. The Thyrotropin (TSH)-Releasing Hormone Receptor: Interaction with TSH and Autoantibodies , 1998 .
[318] J. Wess,et al. Molecular basis of receptor/G-protein-coupling selectivity. , 1998, Pharmacology & therapeutics.
[319] T. Gudermann,et al. A conserved tyrosine residue (Y601) in transmembrane domain 5 of the human thyrotropin receptor serves as a molecular switch to determine G‐protein coupling , 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[320] A. Hsueh,et al. Conversion of thyrotropin heterodimer to a biologically active single-chain. , 1998, Endocrinology.
[321] T. Gudermann,et al. Severe congenital hyperthyroidism caused by a germ-line neo mutation in the extracellular portion of the thyrotropin receptor. , 1998, The Journal of clinical endocrinology and metabolism.
[322] C. Spitzweg,et al. Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1998 by The Endocrine Society Thyrotropin Receptor Expression in Graves ’ Orbital Adipose/Connective Tissues: Potential Autoantigen in , 2022 .
[323] F. Cetani,et al. Hyperfunctioning thyroid nodules in toxic multinodular goiter share activating thyrotropin receptor mutations with solitary toxic adenoma. , 1998, The Journal of clinical endocrinology and metabolism.
[324] K. Tanaka,et al. Thyrotropin Receptor Cleavage at Site 1 Does Not Involve a Specific Amino Acid Motif but Instead Depends on the Presence of the Unique, 50 Amino Acid Insertion* , 1998, The Journal of Biological Chemistry.
[325] E. Milgrom,et al. Cleavage and shedding of the TSH receptor. , 1997, European journal of endocrinology.
[326] B. Rapoport,et al. An N-Linked Glycosylation Motif from the Noncleaving Luteinizing Hormone Receptor Substituted for the Homologous Region (Gly367 to Glu369) of the Thyrotropin Receptor Prevents Cleavage at Its Second, Downstream Site* , 1997, The Journal of Biological Chemistry.
[327] R. Paschke,et al. Somatic Mutations in the Thyrotropin Receptor Gene and Not in the Gsα Protein Gene in 31 Toxic Thyroid Nodules1 , 1997 .
[328] B. Kobilka,et al. Co-expression of Defective Luteinizing Hormone Receptor Fragments Partially Reconstitutes Ligand-induced Signal Generation* , 1997, The Journal of Biological Chemistry.
[329] T. Gudermann,et al. Mutations of the human thyrotropin receptor gene causing thyroid hypoplasia and persistent congenital hypothyroidism. , 1997, The Journal of clinical endocrinology and metabolism.
[330] K. Usadel,et al. Glycosylation variants of human TSH selectively activate signal transduction pathways , 1997, Molecular and Cellular Endocrinology.
[331] P. Kopp,et al. Congenital hyperthyroidism caused by a solitary toxic adenoma harboring a novel somatic mutation (serine281-->isoleucine) in the extracellular domain of the thyrotropin receptor. , 1997, The Journal of clinical investigation.
[332] B. Weintraub,et al. Novel insights into the molecular mechanisms of human thyrotropin action: structural, physiological, and therapeutic implications for the glycoprotein hormone family. , 1997, Endocrine reviews.
[333] B. Rapoport,et al. Engineering the Human Thyrotropin Receptor Ectodomain from a Non-secreted Form to a Secreted, Highly Immunoreactive Glycoprotein That Neutralizes Autoantibodies in Graves’ Patients’ Sera* , 1997, The Journal of Biological Chemistry.
[334] K. Tanaka,et al. Evidence that the thyrotropin receptor ectodomain contains not one, but two, cleavage sites. , 1997, Endocrinology.
[335] J. Parma,et al. Constitutive activation of the TSH receptor by spontaneous mutations affecting the N‐terminal extracellular domain , 1997, FEBS letters.
[336] E. Milgrom,et al. Four families with loss of function mutations of the thyrotropin receptor. , 1996, The Journal of clinical endocrinology and metabolism.
[337] B. Rapoport,et al. Evidence for negative cooperativity among human thyrotropin receptors overexpressed in mammalian cells. , 1996, Endocrinology.
[338] B. Weintraub,et al. Structure-function studies of human TSH New advances in design of glycoprotein hormone analogs , 1996, Trends in Endocrinology & Metabolism.
[339] B. Weintraub,et al. Engineering human glycoprotein hormone superactive analogues , 1996, Nature Biotechnology.
[340] T. Davies,et al. Multimeric complex formation by the thyrotropin receptor in solubilized thyroid membranes. , 1996, Endocrinology.
[341] Michel Bouvier,et al. A Peptide Derived from a β2-Adrenergic Receptor Transmembrane Domain Inhibits Both Receptor Dimerization and Activation* , 1996, The Journal of Biological Chemistry.
[342] A. Allgeier,et al. Specific activation of the thyrotropin receptor by trypsin , 1996, Molecular and Cellular Endocrinology.
[343] T. Mori,et al. Constitutive activation of the thyrotropin receptor by mutating CYS-636 in the sixth transmembrane segment. , 1996, Biochemical and biophysical research communications.
[344] E. Milgrom,et al. Shedding of Human Thyrotropin Receptor Ectodomain , 1996, The Journal of Biological Chemistry.
[345] S. Swillens,et al. Functional characteristics of three new germline mutations of the thyrotropin receptor gene causing autosomal dominant toxic thyroid hyperplasia. , 1996, The Journal of clinical endocrinology and metabolism.
[346] G. Schultz,et al. The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[347] F. Cetani,et al. Differential effects of NaCl concentration on the constitutive activity of the thyrotropin and the luteinizing hormone/chorionic gonadotropin receptors , 1996, FEBS letters.
[348] J. Hershman,et al. Thyrotropic action of human chorionic gonadotropin. , 1995, Thyroid : official journal of the American Thyroid Association.
[349] S. Swillens,et al. Somatic and germline mutations of the TSH receptor gene in thyroid diseases. , 1995, The Journal of clinical endocrinology and metabolism.
[350] R. Wood,et al. Targeted disruption of the pituitary glycoprotein hormone alpha-subunit produces hypogonadal and hypothyroid mice. , 1995, Genes & development.
[351] J. Raymond. Multiple mechanisms of receptor-G protein signaling specificity. , 1995, The American journal of physiology.
[352] P. Kopp,et al. The thyrotropin (TSH) receptor transmembrane domain mutation (Pro556-Leu) in the hypothyroid hyt/hyt mouse results in plasma membrane targeting but defective TSH binding. , 1995, Endocrinology.
[353] T. Mori,et al. Constitutive activation of the thyrotropin receptor by deletion of a portion of the extracellular domain. , 1995, Biochemical and Biophysical Research Communications - BBRC.
[354] S. Swillens,et al. Somatic mutations causing constitutive activity of the thyrotropin receptor are the major cause of hyperfunctioning thyroid adenomas: identification of additional mutations activating both the cyclic adenosine 3',5'-monophosphate and inositol phosphate-Ca2+ cascades. , 1995, Molecular endocrinology.
[355] Y. Hayashi,et al. Brief report: resistance to thyrotropin caused by mutations in the thyrotropin-receptor gene. , 1995, The New England journal of medicine.
[356] A. Shenker,et al. Constitutive activation of cyclic AMP but not phosphatidylinositol signaling caused by four mutations in the 6th transmembrane helix of the human thyrotropin receptor , 1994, FEBS letters.
[357] D. C. Harris,et al. Crystal structure of human chorionic gonadotropin , 1994, Nature.
[358] G. Schultz,et al. The human thyrotropin receptor activates G-proteins Gs and Gq/11. , 1994, The Journal of biological chemistry.
[359] T. Mori,et al. The amino-terminal half of the cytoplasmic tail of the thyrotropin receptor is essential for full activities of receptor function. , 1994, Biochemical and biophysical research communications.
[360] T. Akamizu,et al. The middle portion in the second cytoplasmic loop of the thyrotropin receptor plays a crucial role in adenylate cyclase activation. , 1994, Molecular endocrinology.
[361] T. Mori,et al. The intracellular region adjacent to plasma membrane (residues 684-692) of the thyrotropin receptor is important for phosphoinositide signaling but not for agonist-induced adenylate cyclase activation. , 1994, Biochemical and biophysical research communications.
[362] S. Kosugi,et al. The first cytoplasmic loop of the thyrotropin receptor is important for phosphoinositide signaling but not for agonist‐induced adenylate cyclase activation , 1994, FEBS letters.
[363] R. Grumbles,et al. Identification of a point mutation in the thyrotropin receptor of the hyt/hyt hypothyroid mouse. , 1994, Molecular endocrinology.
[364] J. Parma,et al. Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas , 1993, Nature.
[365] B. Weintraub,et al. Recombinant Human Thyroid Stimulating Hormone: Development of a Biotechnology Product for Detection of Metastatic Lesions of Thyroid Carcinoma , 1993, Bio/Technology.
[366] M. Ascoli,et al. The regulation of the binding affinity of the luteinizing hormone/choriogonadotropin receptor by sodium ions is mediated by a highly conserved aspartate located in the second transmembrane domain of G protein-coupled receptors. , 1993, Molecular endocrinology.
[367] J. Parma,et al. The thyrotropin receptor and the regulation of thyrocyte function and growth. , 1992, Endocrine reviews.
[368] E. Milgrom,et al. Two-subunit structure of the human thyrotropin receptor. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[369] T. Akamizu,et al. Site-directed mutagenesis of a portion of the extracellular domain of the rat thyrotropin receptor important in autoimmune thyroid disease and nonhomologous with gonadotropin receptors. Relationship of functional and immunogenic domains. , 1991, The Journal of biological chemistry.
[370] D. Russo,et al. Thyrotropin-luteinizing hormone/chorionic gonadotropin receptor extracellular domain chimeras as probes for thyrotropin receptor function. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[371] D. Russo,et al. Functional analysis of the cytoplasmic domains of the human thyrotropin receptor by site-directed mutagenesis. , 1990, The Journal of biological chemistry.
[372] J. Ramachandran,et al. Structure and Function of G Protein Coupled Receptors , 1990, Pharmaceutical Research.
[373] J. Dumont,et al. Thyrotropin activates both the cyclic AMP and the PIP2casades in CHO cells expressing the human cDNA of TSH receptor , 1990, Molecular and Cellular Endocrinology.
[374] R. Sprengel,et al. Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing. , 1990, Molecular endocrinology.
[375] E. Milgrom,et al. Cloning, sequencing and expression of human TSH receptor. , 1990, Biochemical and biophysical research communications.
[376] M. Parmentier,et al. Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies. , 1989, Biochemical and biophysical research communications.
[377] B. Rapoport,et al. Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor. , 1989, Biochemical and biophysical research communications.
[378] M. Parmentier,et al. Molecular cloning of the thyrotropin receptor. , 1989, Science.
[379] P. Arner,et al. Regulation of lipolysis during the neonatal period. Importance of thyrotropin. , 1988, The Journal of clinical investigation.
[380] J. Mockel,et al. Dual activation by thyrotropin of the phospholipase C and cyclic AMP cascades in human thyroid , 1987, Molecular and Cellular Endocrinology.
[381] S. Amr,et al. Relevance of the low and high affinity thyrotropin-binding sites of human thyroid membranes to the stimulation of adenylate cyclase. , 1984, Endocrinology.
[382] P. Beck‐Peccoz,et al. Excess of beta-subunit of thyrotropin (TSH) in patients with idiopathic central hypothyroidism due to the secretion of TSH with reduced biological activity. , 1983, The Journal of clinical endocrinology and metabolism.
[383] A. Saltiel,et al. Thyrotropin binding to porcine thyroid plasma membranes: Kinetic and thermodynamic analyses , 1982, Molecular and Cellular Endocrinology.
[384] T F Davies,et al. Receptor-binding activity of highly purified bovine luteinizing hormone and thyrotropin, and their subunits. , 1980, Endocrinology.
[385] B. Weintraub,et al. Thyrotropin-induced hyperthyroidism: use of alpha and beta subunit levels to identify patients with pituitary tumors. , 1977, The Journal of clinical endocrinology and metabolism.
[386] L. Kohn,et al. Thyrotropin receptors in thyroid plasma membranes. Characteristics of thyrotropin binding and solubilization of thyrotropin receptor activity by tryptic digestion. , 1975, The Journal of biological chemistry.
[387] L. Kohn,et al. Experimental exophthalmos. Binding of thyrotropin and an exophthalmogenic factor derived from thyrotropin to retro-orbital tissue plasma membranes. , 1975, The Journal of biological chemistry.
[388] B. Weintraub,et al. Pituitary secretion of free alpha and beta subunit of human thyrotropin in patients with thyroid disorders. , 1975, The Journal of clinical endocrinology and metabolism.
[389] J. Wolff,et al. The contribution of subunits of thyroid stimulating hormone to the binding and biological activity of thyrotropin. , 1974, Proceedings of the National Academy of Sciences of the United States of America.
[390] R. Canfield,et al. Evidence that chorionic gonadotropin has intrinsic thyrotropic activity. , 1974, Biochemical and biophysical research communications.
[391] R. Summers,et al. Relaxin family peptides and their receptors. , 2013, Physiological reviews.
[392] R. Asato,et al. Two rare TSH receptor amino acid substitutions in toxic thyroid adenomas. , 2012, Endocrine journal.
[393] H. Biebermann,et al. Frequent TSH receptor genetic alterations with variable signaling impairment in a large series of children with nonautoimmune isolated hyperthyrotropinemia. , 2012, The Journal of clinical endocrinology and metabolism.
[394] Vadim Cherezov,et al. Diversity and modularity of G protein-coupled receptor structures. , 2012, Trends in pharmacological sciences.
[395] Arnau Cordomí,et al. The G-protein coupled receptor family: actors with many faces. , 2012, Current pharmaceutical design.
[396] R. Stevens,et al. Structure of the human k-opioid receptor in complex with JDTic , 2012 .
[397] J. Dumont,et al. Genetic hyperthyroidism: hyperthyroidism due to activating TSHR mutations. , 2011, European journal of endocrinology.
[398] G. V. van Westen,et al. Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation. , 2011, Trends in pharmacological sciences.
[399] A. Miyauchi,et al. Deletion of thyrotropin receptor residue Asp403 in a hyperfunctioning thyroid nodule provides insight into the role of the ectodomain in ligand-induced receptor activation , 2011, Journal of Endocrinological Investigation.
[400] L. Devi,et al. Exploring a role for heteromerization in GPCR signalling specificity. , 2011, The Biochemical journal.
[401] G. Krause,et al. Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor , 2010, Cellular and Molecular Life Sciences.
[402] E. Marchioni,et al. TSH receptor and thyroid-specific gene expression in human skin. , 2010, The Journal of investigative dermatology.
[403] J. Gregory,et al. TSH receptor activation and body composition. , 2010, The Journal of endocrinology.
[404] R. Latif,et al. Characterization of thyrotropin receptor antibody-induced signaling cascades. , 2009, Endocrinology.
[405] H. Hamm,et al. Heterotrimeric G protein activation by G-protein-coupled receptors , 2008, Nature Reviews Molecular Cell Biology.
[406] Helgi B. Schiöth,et al. Structural diversity of G protein-coupled receptors and significance for drug discovery , 2008, Nature Reviews Drug Discovery.
[407] R. Paschke,et al. Structural determinants for g protein activation and selectivity in the second intracellular loop of the thyrotropin receptor. , 2005, Endocrinology.
[408] S. Costagliola,et al. A physiological role for the posttranslational cleavage of the thyrotropin receptor? , 2004, Endocrinology.
[409] T. Gudermann,et al. The structural basis of G-protein-coupled receptor function and dysfunction in human diseases. , 2002, Reviews of physiology, biochemistry and pharmacology.
[410] M. Ludgate,et al. Animal models of Graves' disease. , 2000, European journal of endocrinology.
[411] K. Tanaka,et al. On the functional importance of thyrotropin receptor intramolecular cleavage. , 1999, Endocrinology.
[412] B. Rapoport,et al. The thyrotropin (TSH) receptor: interaction with TSH and autoantibodies. , 1998, Endocrine reviews.
[413] J. Shine,et al. Protein-coupled Receptors , 1996 .
[414] J. Ballesteros,et al. [19] Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors , 1995 .
[415] P. Evans,et al. Agonist-specific coupling of G-protein-coupled receptors to second-messenger systems. , 1995, Progress in brain research.
[416] D. Russo,et al. Site-directed mutagenesis of the human thyrotropin receptor: role of asparagine-linked oligosaccharides in the expression of a functional receptor. , 1991, Molecular endocrinology.
[417] B. Weintraub,et al. Biological activity and metabolic clearance of a recombinant human thyrotropin produced in Chinese hamster ovary cells. , 1991, Endocrinology.