Optimization and prevalidation of the in vitro AR CALUX method to test androgenic and antiandrogenic activity of compounds.

[1]  H. Ahr,et al.  Screening for (anti)androgenic properties using a standard operation protocol based on the human stably transfected androgen sensitive PALM cell line. First steps towards validation. , 2010, Reproductive toxicology.

[2]  S Coecke,et al.  The use of metabolising systems for in vitro testing of endocrine disruptors. , 2008, Current drug metabolism.

[3]  Bart Van der Burg,et al.  Detection of multiple hormonal activities in wastewater effluents and surface water, using a panel of steroid receptor CALUX bioassays. , 2008, Environmental science & technology.

[4]  H Witters,et al.  Screening of endocrine disrupting chemicals with MELN cells, an ER-transactivation assay combined with cytotoxicity assessment. , 2007, Toxicology in vitro : an international journal published in association with BIBRA.

[5]  B. van der Burg,et al.  Examination of the in vitro (anti)estrogenic, (anti)androgenic and (anti)dioxin-like activities of tetralin, indane and isochroman derivatives using receptor-specific bioassays. , 2005, Toxicology letters.

[6]  M. Iida,et al.  Evaluation of a rapid in vitro androgen receptor transcriptional activation assay using AR-EcoScreen cells. , 2005, Toxicology in vitro : an international journal published in association with BIBRA.

[7]  Jens C. Streibig,et al.  Bioassay analysis using R , 2005 .

[8]  H. Gelbke,et al.  OECD test strategies and methods for endocrine disruptors. , 2004, Toxicology.

[9]  Bart van der Burg,et al.  Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays. , 2004, Toxicological sciences : an official journal of the Society of Toxicology.

[10]  Valérie Zuang,et al.  A Modular Approach to the ECVAM Principles on Test Validity , 2004, Alternatives to laboratory animals : ATLA.

[11]  Abraham Brouwer,et al.  Development of androgen- and estrogen-responsive bioassays, members of a panel of human cell line-based highly selective steroid-responsive bioassays. , 2004, Toxicological sciences : an official journal of the Society of Toxicology.

[12]  L. Gray,et al.  A novel cell line, MDA-kb2, that stably expresses an androgen- and glucocorticoid-responsive reporter for the detection of hormone receptor agonists and antagonists. , 2002, Toxicological sciences : an official journal of the Society of Toxicology.

[13]  E. M. de Groene,et al.  Development of an androgen reporter gene assay (AR-LUX) utilizing a human cell line with an endogenously regulated androgen receptor. , 2001, Analytical biochemistry.

[14]  F. Orio,et al.  A stable prostatic bioluminescent cell line to investigate androgen and antiandrogen effects , 2000, Molecular and Cellular Endocrinology.

[15]  Michael Balls,et al.  The Role of Prevalidation in the Development, Validation and Acceptance of Alternative Methods , 1995 .

[16]  G. Chalepakis,et al.  Gene regulation by steroid hormones. , 1989, Cell.