Aging in the CNS: Comparison of gray/white matter volume and diffusion tensor data

This study investigated the global and regional effects of aging on brain volume, mean diffusivity (MD), and fractional anisotropy (FA) in 73 normal female subjects using voxel-based analysis. On a global scale, gray matter volume and FA were negatively correlated, whereas MD was positively correlated with age. Voxel-wise analyses showed brain volume and FA were negatively correlated predominantly in anterior structures, whereas MD was positively correlated in the cortical gray matter and periventricular white matter. Volume preservation was observed in the cingulate gyrus and subjacent white matter. FA increase was observed in the putamen. Voxel-based direct comparisons of volume and diffusion properties showed FA was more strongly negatively correlated in the fronto-temporal white matter, compared with volume and MD. Stronger positive correlation of MD was observed in the thalamus, caudate nucleus, and midbrain and stronger negative correlation of brain volume was observed in the frontal lobe and basal ganglia, compared with the other. These results indicate that diffusion properties and brain volume are complementary markers to the effects of aging.

[1]  D. Mathalon,et al.  A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. , 1994, Archives of neurology.

[2]  M S Buchsbaum,et al.  Regional and global changes in cerebral diffusion with normal aging. , 2001, AJNR. American journal of neuroradiology.

[3]  D. DeLong,et al.  The effect of aging on the apparent diffusion coefficient of normal-appearing white matter. , 2000, AJR. American journal of roentgenology.

[4]  Martha Elizabeth Shenton,et al.  Voxel-Based Morphometric Analysis of Gray Matter in First Episode Schizophrenia , 2002, NeuroImage.

[5]  C. Fennema-Notestine,et al.  Effects of age on tissues and regions of the cerebrum and cerebellum , 2001, Neurobiology of Aging.

[6]  J. Tsuruda,et al.  Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system. , 1990, Radiology.

[7]  J. Voogd,et al.  The human central nervous system , 1978 .

[8]  G J Barker,et al.  The pathogenesis of lesions and normal-appearing white matter changes in multiple sclerosis: a serial diffusion MRI study. , 2000, Brain : a journal of neurology.

[9]  H S Markus,et al.  Characterization of white matter damage in ischemic leukoaraiosis with diffusion tensor MRI. , 1999, Stroke.

[10]  Karl J. Friston,et al.  Neural basis of an inherited speech and language disorder. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[11]  H. Haug.  [Effect of secular acceleration on the human brain weight and its changes during aging]. , 1984, Gegenbaurs morphologisches Jahrbuch.

[12]  D. Graham,et al.  Aging‐associated Changes in Human Brain , 1997, Journal of neuropathology and experimental neurology.

[13]  R. Poldrack,et al.  Microstructure of Temporo-Parietal White Matter as a Basis for Reading Ability Evidence from Diffusion Tensor Magnetic Resonance Imaging , 2000, Neuron.

[14]  R. Kikinis,et al.  White matter changes with normal aging , 1998, Neurology.

[15]  Volkmar Glauche,et al.  Diffusion tensor MRI of early upper motor neuron involvement in amyotrophic lateral sclerosis. , 2004, Brain : a journal of neurology.

[16]  D. Head,et al.  Selective aging of the human cerebral cortex observed in vivo: differential vulnerability of the prefrontal gray matter. , 1997, Cerebral cortex.

[17]  Glyn Johnson,et al.  White matter abnormalities in HIV-1 infection: A diffusion tensor imaging study , 2001, Psychiatry Research: Neuroimaging.

[18]  Christian Beaulieu,et al.  Diffusion anisotropy in subcortical white matter and cortical gray matter: Changes with aging and the role of CSF‐suppression , 2004, Journal of magnetic resonance imaging : JMRI.

[19]  Haruyasu Yamada,et al.  Normal aging in the central nervous system: quantitative MR diffusion-tensor analysis , 2002, Neurobiology of Aging.

[20]  Yasuhiro Kawasaki,et al.  Regional changes in brain gray and white matter in patients with schizophrenia demonstrated with voxel-based analysis of MRI , 2002, Schizophrenia Research.

[21]  Karl J. Friston,et al.  A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains , 2001, NeuroImage.

[22]  Edith V. Sullivan,et al.  Equivalent disruption of regional white matter microstructure in ageing healthy men and women , 2001, Neuroreport.

[23]  Isabelle Bloch,et al.  Eddy-Current Distortion Correction and Robust Tensor Estimation for MR Diffusion Imaging , 2001, MICCAI.

[24]  T. Kemper,et al.  Neuroanatomical and neuropathological changes during aging and dementia. , 1994 .

[25]  Osamu Abe,et al.  Topography of the Human Corpus Callosum Using Diffusion Tensor Tractography , 2004, Journal of computer assisted tomography.

[26]  Hiroshi Fukuda,et al.  Voxel-based morphometry of human brain with age and cerebrovascular risk factors , 2004, Neurobiology of Aging.

[27]  Osamu Abe,et al.  Amyotrophic lateral sclerosis: diffusion tensor tractography and voxel‐based analysis , 2004, NMR in biomedicine.

[28]  F. Fazekas,et al.  The morphologic correlate of incidental punctate white matter hyperintensities on MR images. , 1991, AJNR. American journal of neuroradiology.

[29]  D. Kennedy,et al.  The young adult human brain: an MRI-based morphometric analysis. , 1994, Cerebral cortex.

[30]  K O Lim,et al.  A controlled study of cortical gray matter and ventricular changes in alcoholic men over a 5-year interval. , 1998, Archives of general psychiatry.

[31]  Faith M. Gunning-Dixon,et al.  Aging, sexual dimorphism, and hemispheric asymmetry of the cerebral cortex: replicability of regional differences in volume , 2004, Neurobiology of Aging.

[32]  Karl J. Friston,et al.  Statistical parametric maps in functional imaging: A general linear approach , 1994 .

[33]  R. C. Oldfield.  The assessment and analysis of handedness: the Edinburgh inventory. , 1971, Neuropsychologia.

[34]  J. Jinkins,et al.  Atlas of Neuroradiologic Embryology, Anatomy, and Variants , 2000 .

[35]  D. Salat,et al.  Prefrontal gray and white matter volumes in healthy aging and Alzheimer disease. , 1999, Archives of neurology.

[36]  P. Basser,et al.  MR diffusion tensor spectroscopy and imaging. , 1994, Biophysical journal.

[37]  Simon E. Fisher,et al.  Localisation of a gene implicated in a severe speech and language disorder , 1997, Nature Genetics.

[38]  A. Alavi,et al.  MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. , 1987, AJR. American journal of roentgenology.

[39]  James R. Moore,et al.  Correction for distortion of echo‐planar images used to calculate the apparent diffusion coefficient , 1996, Magnetic resonance in medicine.

[40]  James C. Gee,et al.  Spatial transformations of diffusion tensor magnetic resonance images , 2001, IEEE Transactions on Medical Imaging.

[41]  Alberto Beltramello,et al.  A comparison between the accuracy of voxel‐based morphometry and hippocampal volumetry in Alzheimer's disease , 2004, Journal of magnetic resonance imaging : JMRI.

[42]  J A Corsellis,et al.  VARIATION WITH AGE IN THE VOLUMES OF GREY AND WHITE MATTER IN THE CEREBRAL HEMISPHERES OF MAN: MEASUREMENTS WITH AN IMAGE ANALYSER , 1980, Neuropathology and applied neurobiology.

[43]  Janice E. Knoefel,et al.  Clinical neurology of aging , 1985 .

[44]  A. Dale,et al.  Age-related alterations in white matter microstructure measured by diffusion tensor imaging , 2005, Neurobiology of Aging.

[45]  B. Turetsky,et al.  Preservation of normal cognitive functioning in elderly subjects with extensive white-matter lesions of long duration. , 1990, Archives of General Psychiatry.

[46]  A. Malhotra,et al.  Sex differences in frontal lobe white matter microstructure: a DTI study , 2003, Neuroreport.

[47]  Karl J. Friston,et al.  453 Mapping of gray matter changes in schizophrenia , 1997, Schizophrenia Research.

[48]  H Lechner,et al.  White matter signal abnormalities in normal individuals: correlation with carotid ultrasonography, cerebral blood flow measurements, and cerebrovascular risk factors. , 1988, Stroke.

[49]  S. Yamaguchi,et al.  Gender effects on age-related changes in brain structure. , 2000, AJNR. American journal of neuroradiology.

[50]  M Skalej,et al.  Patterns of age-related shrinkage in cerebellum and brainstem observed in vivo using three-dimensional MRI volumetry. , 1999, Cerebral cortex.

[51]  W. Meier-Ruge,et al.  Age‐Related White Matter Atrophy in the Human Brain , 1992, Annals of the New York Academy of Sciences.

[52]  Manuel Desco,et al.  Influence of the normalization template on the outcome of statistical parametric mapping of PET scans , 2003, NeuroImage.

[53]  Marco Rovaris,et al.  Assessment of normal-appearing white and gray matter in patients with primary progressive multiple sclerosis: a diffusion-tensor magnetic resonance imaging study. , 2002, Archives of neurology.

[54]  K. Lim,et al.  Age‐related decline in brain white matter anisotropy measured with spatially corrected echo‐planar diffusion tensor imaging , 2000, Magnetic resonance in medicine.

[55]  C Thomsen,et al.  Increased self‐diffusion of brain water in normal aging , 1994, Journal of magnetic resonance imaging : JMRI.

[56]  R. DeTeresa,et al.  Neocortical cell counts in normal human adult aging , 1987, Annals of neurology.

[57]  Karl J. Friston,et al.  Cortical grey matter and benzodiazepine receptors in malformations of cortical development. A voxel-based comparison of structural and functional imaging data. , 1997, Brain : a journal of neurology.

[58]  J. Townsend,et al.  Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteers. , 2000, Radiology.