Monitoring Editor

Transitions between the two phases of the cell growth cycle can account for the environmental stress response, the growth-rate response, and the cross-protection between slow growth and various types of stress factors. It is suggested that this mechanism is conserved across budding and fission yeast and normal human cells.

[1]  H BRICAIRE,et al.  Journal of Endocrinology , 1939, Nature.

[2]  R. E. Wilson,et al.  Fermentation Process Control, Population Dynamics of a Continuous Propagator for Microorganisms , 1954 .

[3]  L. Hartwell,et al.  Genetic Control of the Cell Division Cycle in Yeast: V. Genetic Analysis of cdc Mutants. , 1973, Genetics.

[4]  D. Lloyd,et al.  Respiratory Oscillations and Heat Evolution in Synchronously Dividing Cultures of the Fission Yeast Schizosaccharomyces pombe 972h , 1973 .

[5]  L. Hartwell,et al.  Three Additional Genes Required for Deoxyribonucleic Acid Synthesis in Saccharomyces cerevisiae , 1973, Journal of bacteriology.

[6]  L. Hartwell,et al.  Genetic control of the cell division cycle in yeast. , 1974, Science.

[7]  A. Wiemken,et al.  Amino Acid Pools and Metabolism During the Cell Division Cycle of Arginine-Grown Candida utilis , 1974, Journal of bacteriology.

[8]  P. Nurse,et al.  Novel cell cycle control of RNA synthesis in yeast , 1978, Nature.

[9]  P. Nurse,et al.  Altered patterns of ribonucleic acid synthesis during the cell cycle: a mechanism compensating for variation in gene concentration. , 1979, Journal of cell science.

[10]  P. Nurse,et al.  Analysis of the significance of a periodic, cell size-controlled doubling in rates of macromolecular synthesis for the control of balanced exponential growth of fission yeast cells. , 1979, Journal of cell science.

[11]  P. Nurse,et al.  Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast , 1981, Nature.

[12]  P. Nurse,et al.  Functionally homologous cell cycle control genes in budding and fission yeast , 1982, Nature.

[13]  R. Mitchel,et al.  Heat-shock induction of ionizing radiation resistance in Saccharomyces cerevisiae, and correlation with stationary growth phase. , 1982, Radiation research.

[14]  R. Mitchel,et al.  Heat-shock induction of ultraviolet light resistance in Saccharomyces cerevisiae. , 1983, Radiation research.

[15]  S. Reed,et al.  The role of p34 kinases in the G1 to S-phase transition. , 1992, Annual review of cell biology.

[16]  Bruce Futcher,et al.  Stress resistance of yeast cells is largely independent of cell cycle phase , 1993, Yeast.

[17]  B Hamilton,et al.  Nuclear localization of the C2H2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity. , 1998, Genes & development.

[18]  Michael Ruogu Zhang,et al.  Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization. , 1998, Molecular biology of the cell.

[19]  Chi-Yung Lai,et al.  Heat stress-induced life span extension in yeast. , 1998, Experimental cell research.

[20]  M. Ward,et al.  Yeast PKA represses Msn2p/Msn4p‐dependent gene expression to regulate growth, stress response and glycogen accumulation , 1998, The EMBO journal.

[21]  D. Botstein,et al.  Cluster analysis and display of genome-wide expression patterns. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[22]  Michael N. Hall,et al.  The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors , 1999, Nature.

[23]  Pier Paolo Pandolfi,et al.  The p66shc adaptor protein controls oxidative stress response and life span in mammals , 1999, Nature.

[24]  D. Botstein,et al.  Genomic expression programs in the response of yeast cells to environmental changes. , 2000, Molecular biology of the cell.

[25]  W. Liu,et al.  Cellular stress responses oscillate in synchronization with the ultradian oscillation of energy metabolism in the yeast Saccharomyces cerevisiae. , 2000, FEMS microbiology letters.

[26]  J. Cypser,et al.  Multiple stressors in Caenorhabditis elegans induce stress hormesis and extended longevity. , 2002, The journals of gerontology. Series A, Biological sciences and medical sciences.

[27]  C. Ball,et al.  Identification of genes periodically expressed in the human cell cycle and their expression in tumors. , 2002, Molecular biology of the cell.

[28]  Ingnyol Jin,et al.  Involvement of oxidative stress in the regulation of H(2)S production during ultradian metabolic oscillation of Saccharomyces cerevisiae. , 2003, FEMS microbiology letters.

[29]  A. Brazma,et al.  Global transcriptional responses of fission yeast to environmental stress. , 2003, Molecular biology of the cell.

[30]  Armin Fiechter,et al.  Changes in carbohydrate composition and trehalase-activity during the budding cycle of Saccharomyces cerevisiae , 2004, Archiv für Mikrobiologie.

[31]  D. Murray,et al.  A genomewide oscillation in transcription gates DNA replication and cell cycle. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[32]  P. Lio’,et al.  Periodic gene expression program of the fission yeast cell cycle , 2004, Nature Genetics.

[33]  M. Thattai,et al.  Stochastic Gene Expression in Fluctuating Environments , 2004, Genetics.

[34]  David Botstein,et al.  Nutritional homeostasis in batch and steady-state culture of yeast. , 2004, Molecular biology of the cell.

[35]  H. Meyenburg.  Energetics of the budding cycle of Saccharomyces cerevisiae during glucose limited aerobic growth , 2004, Archiv für Mikrobiologie.

[36]  David Botstein,et al.  GO: : TermFinder--open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes , 2004, Bioinform..

[37]  David Botstein,et al.  Diverse and specific gene expression responses to stresses in cultured human cells. , 2004, Molecular biology of the cell.

[38]  Adam P. Rosebrock,et al.  The Cell Cycle–Regulated Genes of Schizosaccharomyces pombe , 2005, PLoS biology.

[39]  A. Kudlicki,et al.  Logic of the Yeast Metabolic Cycle: Temporal Compartmentalization of Cellular Processes , 2005, Science.

[40]  L. Wong,et al.  Identification of cell cycle-regulated genes in fission yeast. , 2005, Molecular biology of the cell.

[41]  Matt Kaeberlein,et al.  Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients , 2005, Science.

[42]  Ole Winther,et al.  Growth-rate regulated genes have profound impact on interpretation of transcriptome profiling in Saccharomyces cerevisiae , 2006, Genome Biology.

[43]  Matt Kaeberlein,et al.  Extension of chronological life span in yeast by decreased TOR pathway signaling. , 2006, Genes & development.

[44]  R. Baumeister,et al.  Endocrine signaling in Caenorhabditis elegans controls stress response and longevity. , 2006, The Journal of endocrinology.

[45]  V. Loeschcke,et al.  Longevity and the stress response in Drosophila , 2007, Experimental Gerontology.

[46]  David Lloyd,et al.  A tuneable attractor underlies yeast respiratory dynamics , 2007, Biosyst..

[47]  Matthew J. Brauer,et al.  Coordination of growth rate, cell cycle, stress response, and metabolic activity in yeast. , 2008, Molecular biology of the cell.

[48]  Qi Zheng,et al.  GOEAST: a web-based software toolkit for Gene Ontology enrichment analysis , 2008, Nucleic Acids Res..

[49]  David Botstein,et al.  Influence of genotype and nutrition on survival and metabolism of starving yeast , 2008, Proceedings of the National Academy of Sciences.

[50]  Daniel J. Kvitek,et al.  Variations in Stress Sensitivity and Genomic Expression in Diverse S. cerevisiae Isolates , 2008, PLoS genetics.

[51]  Audrey P Gasch,et al.  Stress-activated genomic expression changes serve a preparative role for impending stress in yeast. , 2008, Molecular biology of the cell.

[52]  T. Finkel,et al.  Coordination of mitochondrial bioenergetics with G1 phase cell cycle progression , 2008, Cell cycle.

[53]  N. Slavov,et al.  Correlation signature of the macroscopic states of the gene regulatory network in cancer , 2009, Proceedings of the National Academy of Sciences.

[54]  L. Cantley,et al.  Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.

[55]  Matthew J. Brauer,et al.  Slow Growth Induces Heat-shock Resistance in Normal and Respiratory-deficient Yeast , 2022 .

[56]  Edoardo M. Airoldi,et al.  Predicting Cellular Growth from Gene Expression Signatures , 2009, PLoS Comput. Biol..

[57]  Badrinath Roysam,et al.  A hyperfused mitochondrial state achieved at G1–S regulates cyclin E buildup and entry into S phase , 2009, Proceedings of the National Academy of Sciences.

[58]  K. Shiozaki.  Nutrition-Minded Cell Cycle , 2009, Science Signaling.

[59]  Russell G. Jones,et al.  Tumor suppressors and cell metabolism: a recipe for cancer growth. , 2009, Genes & development.

[60]  David Botstein,et al.  Evaluating Gene Expression Dynamics Using Pairwise RNA FISH Data , 2010, PLoS Comput. Biol..

[61]  Mark A. McCormick,et al.  Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity , 2010, Proceedings of the National Academy of Sciences.

[62]  Saumyadipta Pyne,et al.  BAYESIAN META-ANALYSIS FOR IDENTIFYING PERIODICALLY EXPRESSED GENES IN FISSION YEAST CELL CYCLE , 2010, 1011.2104.

[63]  David Botstein,et al.  Metabolic cycling in single yeast cells from unsynchronized steady-state populations limited on glucose or phosphate , 2010, Proceedings of the National Academy of Sciences.

[64]  O. Pourquié,et al.  Spatiotemporal compartmentalization of key physiological processes during muscle precursor differentiation , 2010, Proceedings of the National Academy of Sciences.

[65]  B. Tu,et al.  Systems approaches for the study of metabolic cycles in yeast. , 2010, Current opinion in genetics & development.

[66]  Elizabeth L. Johnson,et al.  Quiescent Fibroblasts Exhibit High Metabolic Activity , 2010, PLoS biology.

[67]  D. Botstein,et al.  Universality, specificity and regulation of S. cerevisiae growth rate response in different carbon s , 2010 .

[68]  Kevin A. Janes,et al.  Identifying single-cell molecular programs by stochastic profiling , 2010, Nature Methods.

[69]  S. Moncada,et al.  Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes , 2010, Proceedings of the National Academy of Sciences.

[70]  J. Bähler,et al.  Meta-analysis of genome regulation and expression variability across hundreds of environmental and genetic perturbations in fission yeast. , 2010, Molecular bioSystems.

[71]  Nikolai Slavov,et al.  Inference of Sparse Networks with Unobserved Variables. Application to Gene Regulatory Networks , 2010, AISTATS.

[72]  A. Levine,et al.  The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes , 2010, Science.

[73]  D. Botstein,et al.  Metabolic cycling without cell division cycling in respiring yeast , 2011, Proceedings of the National Academy of Sciences.

[74]  Corey Nislow,et al.  Multiple Means to the Same End: The Genetic Basis of Acquired Stress Resistance in Yeast , 2011, PLoS genetics.

[75]  T. Mak,et al.  Regulation of cancer cell metabolism , 2011, Nature Reviews Cancer.

[76]  K. Stoeber,et al.  Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)-β-TrCP, sequentially regulate glycolysis during the cell cycle , 2011, Proceedings of the National Academy of Sciences.

[77]  D. Botstein,et al.  Coupling among growth rate response, metabolic cycle, and cell division cycle in yeast , 2011, Molecular biology of the cell.

[78]  Masaru Tomita,et al.  Redox regulation in respiring Saccharomyces cerevisiae. , 2011, Biochimica et biophysica acta.

[79]  Erin K O'Shea,et al.  Signal-dependent dynamics of transcription factor translocation controls gene expression , 2011, Nature Structural &Molecular Biology.