WHO 2022 classification of penile and scrotal cancers: updates and evolution

Squamous cell carcinoma (SCC) is the most common malignant tumour of the penis. The 2022 WHO classification reinforces the 2016 classification and subclassifies precursor lesions and tumours into human papillomavirus (HPV)‐associated and HPV‐independent types.

[1]  J. Epstein,et al.  Pathological characterization and clinical outcome of penile intraepithelial neoplasia variants: a North American series , 2022, Modern Pathology.

[2]  G. Guimarães,et al.  A comparative study of AJCC and the modified staging system in pT2/pT3 penile squamous cell carcinoma – a validation on an external data set , 2021, Histopathology.

[3]  A. Cubilla,et al.  What is New in the Pathologic Staging of Penile Carcinoma in the 8th Edition of AJCC TNM Model: Rationale for Changes With Practical Stage-by-stage Category Diagnostic Considerations. , 2021, Advances in anatomic pathology.

[4]  P. Nyirády Penile cancer , 2021, Nature Reviews Disease Primers.

[5]  F. Montorsi,et al.  Association Between Human Papillomavirus Infection and Outcome of Perioperative Nodal Radiotherapy for Penile Carcinoma. , 2020, European urology oncology.

[6]  A. Cubilla,et al.  Evolving insights into penile cancer pathology and the eighth edition of the AJCC TNM staging system. , 2020, Urologic oncology.

[7]  C. Bunker,et al.  The management of penile intraepithelial neoplasia (PeIN): clinical and histological features and treatment of 345 patients and a review of the literature , 2020, The Journal of dermatological treatment.

[8]  D. Grignon,et al.  Report From the International Society of Urological Pathology (ISUP) Consultation Conference on Molecular Pathology of Urogenital Cancers V: Recommendations on the Use of Immunohistochemical and Molecular Biomarkers in Penile Cancer. , 2020, The American journal of surgical pathology.

[9]  B. Breyer,et al.  Pathophysiology, Clinical Manifestations, and Treatment of Lichen Sclerosus: a systematic review. , 2020, Urology.

[10]  S. Rais-Bahrami,et al.  Morphology, p16, HPV, and outcomes in squamous cell carcinoma of the penis: a multi-institutional study. , 2019, Human pathology.

[11]  S. Menon,et al.  Histopathological risk scoring system as a tool for predicting lymph nodal metastasis in penile squamous cell carcinoma. , 2019, Pathology.

[12]  A. Cubilla,et al.  Pathology of Invasive and Intraepithelial Penile Neoplasia. , 2019, European urology focus.

[13]  T. Masterson,et al.  Penile cancer epidemiology and risk factors: a contemporary review , 2019, Current opinion in urology.

[14]  Å. Svensson,et al.  Risk Factors for Penile Intraepithelial Neoplasia: A Population-based Register Study in Sweden, 2000-2012. , 2019, Acta dermato-venereologica.

[15]  D. Berney,et al.  The World Health Organisation 2016 classification of penile carcinomas: a review and update from the International Society of Urological Pathology expert‐driven recommendations , 2018, Histopathology.

[16]  M. Amin,et al.  Updates in the Eighth Edition of the Tumor-Node-Metastasis Staging Classification for Urologic Cancers. , 2018, European Urology.

[17]  A. Giuliano,et al.  The relationship between HPV status and chemoradiotherapy in the locoregional control of penile cancer , 2018, World Journal of Urology.

[18]  H. García-Perdomo,et al.  Incidence of penile cancer worldwide: systematic review and meta-analysis , 2017, Revista panamericana de salud publica = Pan American journal of public health.

[19]  E. Winter,et al.  HPV-negative penile squamous cell carcinoma: disruptive mutations in the TP53 gene are common , 2017, Modern Pathology.

[20]  N. Muñoz,et al.  Medullary Carcinoma of the Penis: A Distinctive HPV-related Neoplasm A Report of 12 Cases , 2017, The American journal of surgical pathology.

[21]  B. Longley,et al.  Primary cutaneous adenosquamous carcinoma of the penis: the first characterization of HPV status in this rare and diagnostically challenging entity with review of glandular carcinomas of the penis , 2016, Journal of cutaneous pathology.

[22]  D. Ye,et al.  Preneoplastic and Primary Scrotal Cancer: Updates on Pathogenesis and Diagnostic Evaluation. , 2016, The Urologic clinics of North America.

[23]  E. Velazquez,et al.  Clear Cell Carcinoma of the Penis: An HPV-related Variant of Squamous Cell Carcinoma A Report of 3 Cases , 2016, The American journal of surgical pathology.

[24]  P. Humphrey,et al.  The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours. , 2016, European urology.

[25]  Y. Kong,et al.  Primary invasive extramammary Paget disease on penoscrotum: a clinicopathological analysis of 41 cases. , 2016, Human pathology.

[26]  C. Lezcano,et al.  HPV- and non-HPV-related subtypes of penile squamous cell carcinoma (SCC): Morphological features and differential diagnosis according to the new WHO classification (2015). , 2015, Seminars in diagnostic pathology.

[27]  A. Schrader,et al.  The role of histologic subtype, p16INK4a expression, and presence of human papillomavirus DNA in penile squamous cell carcinoma , 2015, BMC Cancer.

[28]  Maria Helena Tavares Vilela,et al.  Mucoepidermoid carcinoma of the penis: Case report and literature review. , 2015, Canadian Urological Association journal = Journal de l'Association des urologues du Canada.

[29]  B. Dai,et al.  Primary invasive carcinoma associated with penoscrotal extramammary Paget's disease: a clinicopathological analysis of 56 cases , 2015, BJU international.

[30]  J. Kelly,et al.  Penile cancer can be prevented or treated pre-emptively , 2013, BMJ : British Medical Journal.

[31]  K. Delman,et al.  Scrotal cancer survival is influenced by histology: a SEER study , 2013, World Journal of Urology.

[32]  G. Netto,et al.  Distribution and characterization of subtypes of penile intraepithelial neoplasia and their association with invasive carcinomas: a pathological study of 139 lesions in 121 patients. , 2012, Human pathology.

[33]  A. Cubilla,et al.  Advances in the pathology of penile carcinomas. , 2012, Human pathology.

[34]  E. Velazquez,et al.  Histologic classification of penile intraepithelial neoplasia. , 2012, Seminars in diagnostic pathology.

[35]  M. Carneiro,et al.  The impact of cyclooxygenase-2 and vascular endothelial growth factor C immunoexpression on the prognosis of penile carcinoma. , 2012, The Journal of urology.

[36]  G. Netto,et al.  Distinctive Immunohistochemical Profile of Penile Intraepithelial Lesions: A Study of 74 Cases , 2011, The American journal of surgical pathology.

[37]  P. Tamboli,et al.  Warty–basaloid carcinoma: clinicopathological features of a distinctive penile neoplasm. Report of 45 cases , 2010, Modern Pathology.

[38]  T. Morgan,et al.  Primary scrotal cancer: disease characteristics and increasing incidence. , 2008, Urology.

[39]  E. Velazquez,et al.  Carcinoma Cuniculatum: A Distinctive Variant of Penile Squamous Cell Carcinoma: Report of 7 Cases , 2007, The American journal of surgical pathology.

[40]  E. Velazquez,et al.  Pseudohyperplastic Squamous Cell Carcinoma of the Penis Associated With Lichen Sclerosus. An Extremely Well-differentiated, Nonverruciform Neoplasm That Preferentially Affects the Foreskin and Is Frequently Misdiagnosed: A Report of 10 Cases of a Distinctive Clinicopathologic Entity , 2004, The American journal of surgical pathology.

[41]  R. Start AFIP Atlas of Tumor Pathology , 2000 .