Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4

Background Human bronchial epithelial cells synthesize cyclooxygenase and 15‐lipoxygenase products, but the 5‐lipoxygenase (5‐LO) pathway that generates the leukotriene (LT) family of bronchoconstrictor and pro‐inflammatory mediators is thought to be restricted to leucocytes.

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