ZBP1-MLKL necroptotic signaling potentiates radiation-induced antitumor immunity via intratumoral STING pathway activation

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[1]  J. Galon,et al.  The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy , 2020, Nature Reviews Cancer.

[2]  L. Galluzzi,et al.  Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy , 2020, Nature Immunology.

[3]  Lingling Wu,et al.  cGAS-STING–mediated DNA sensing maintains CD8+ T cell stemness and promotes antitumor T cell therapy , 2020, Science Translational Medicine.

[4]  K. Rogers,et al.  MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis , 2020, Nature Communications.

[5]  yang-xin fu,et al.  Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling , 2020, Nature Immunology.

[6]  Jiahuai Han,et al.  Gut stem cell necroptosis by genome instability triggers bowel inflammation , 2020, Nature.

[7]  A. Melcher,et al.  Inflammatory microenvironment remodelling by tumour cells after radiotherapy , 2020, Nature Reviews Cancer.

[8]  David F. Boyd,et al.  Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis , 2020, Cell.

[9]  M. Pasparakis,et al.  Z-nucleic acid sensing triggers ZBP1-dependent necroptosis and inflammation , 2020, Nature.

[10]  R. Fisher,et al.  Head and Neck Squamous Cell Carcinoma , 2020, Definitions.

[11]  G. Sundar,et al.  Prostate Adenocarcinoma , 2020, Definitions.

[12]  L. Galluzzi,et al.  Immunological impact of cell death signaling driven by radiation on the tumor microenvironment , 2019, Nature Immunology.

[13]  Rohit Reja,et al.  Activity of caspase-8 determines plasticity between cell death pathways , 2019, Nature.

[14]  R. Medzhitov,et al.  Harnessing innate immunity in cancer therapy , 2019, Nature.

[15]  I. Melero,et al.  Dendritic cells in cancer immunology and immunotherapy , 2019, Nature Reviews Immunology.

[16]  Nancy R. Zhang,et al.  Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade , 2019, Cell.

[17]  D. Baker,et al.  Intratumoral activation of the necroptotic pathway components RIPK1 and RIPK3 potentiates antitumor immunity , 2019, Science Immunology.

[18]  Zhijian J. Chen,et al.  cGAS in action: Expanding roles in immunity and inflammation , 2019, Science.

[19]  Joshua M. Korn,et al.  Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss , 2018, Nature Medicine.

[20]  T. Luedde,et al.  Necroptosis microenvironment directs lineage commitment in liver cancer , 2018, Nature.

[21]  R. Weichselbaum,et al.  Non‐canonical NF‐&kgr;B Antagonizes STING Sensor‐Mediated DNA Sensing in Radiotherapy , 2018, Immunity.

[22]  Zhijian J. Chen,et al.  The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer , 2018, The Journal of experimental medicine.

[23]  Chuan-Qi Zhong,et al.  RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis , 2018, Nature Cell Biology.

[24]  W. Schulz,et al.  Urothelial Carcinoma , 2018, Methods in Molecular Biology.

[25]  R. Weichselbaum,et al.  Host STING-dependent MDSC mobilization drives extrinsic radiation resistance , 2017, Nature Communications.

[26]  K. Kaestner,et al.  Cytoplasmic chromatin triggers inflammation in senescence and cancer , 2017, Nature.

[27]  H. Leonhardt,et al.  cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders , 2017, Nature.

[28]  Martin A. M. Reijns,et al.  cGAS surveillance of micronuclei links genome instability to innate immunity , 2017, Nature.

[29]  Se-Jin Yoon,et al.  MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation , 2017, Immunity.

[30]  Dennis E Discher,et al.  Mitotic progression following DNA damage enables pattern recognition within micronuclei , 2017, Nature.

[31]  D. Green,et al.  ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences , 2017, Cell.

[32]  Daniel S. Chertow,et al.  Necroptosis: Mechanisms and Relevance to Disease , 2017 .

[33]  L. Zitvogel,et al.  Immunogenic cell death in cancer and infectious disease , 2016, Nature Reviews Immunology.

[34]  G. Coukos,et al.  Radiotherapy combination opportunities leveraging immunity for the next oncology practice , 2017, CA: a cancer journal for clinicians.

[35]  David F. Boyd,et al.  DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death. , 2016, Cell host & microbe.

[36]  Sarah I. Alothman,et al.  The Necrosome Promotes Pancreas Oncogenesis via CXCL1 and Mincle Induced Immune Suppression , 2016, Nature.

[37]  D. Green,et al.  RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8+ T cells , 2015, Science.

[38]  P. Vandenabeele,et al.  Necroptosis and its role in inflammation , 2015, Nature.

[39]  R. Means,et al.  Mitochondrial DNA Stress Primes the Antiviral Innate Immune Response , 2014, Nature.

[40]  R. Weichselbaum,et al.  STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors. , 2014, Immunity.

[41]  M. Delorenzi,et al.  Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy , 2014, Nature Medicine.

[42]  Zhijian J. Chen,et al.  Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway , 2013, Science.

[43]  E. Crawford,et al.  Caspase substrates and cellular remodeling. , 2011, Annual review of biochemistry.

[44]  Sherif A El-Nashar,et al.  Uterine carcinosarcoma. , 2011, Clinical obstetrics and gynecology.

[45]  H. Kantarjian,et al.  Acute myeloid leukemia , 2018, Methods in Molecular Biology.