Carotid Plaque Hemorrhage on Magnetic Resonance Imaging Strongly Predicts Recurrent Ischemia and Stroke

There is a recognized need to improve selection of patients with carotid artery stenosis for carotid endarterectomy (CEA). We assessed the value of magnetic resonance imaging (MRI)‐defined carotid plaque hemorrhage (MRIPH) to predict recurrent ipsilateral cerebral ischemic events, and stroke in symptomatic carotid stenosis.

[1]  P J Gallagher,et al.  Histological Assessment of 526 Symptomatic Carotid Plaques in Relation to the Nature and Timing of Ischemic Symptoms: The Oxford Plaque Study , 2006, Circulation.

[2]  K. Iihara,et al.  ORIGINAL RESEARCH Association between Signal Hyperintensity on T1-Weighted MR Imaging of Carotid Plaques and Ipsilateral Ischemic Events , 2007 .

[3]  P. Rothwell,et al.  Histological Features of Symptomatic Carotid Plaques in Relation to Age and Smoking: The Oxford Plaque Study , 2010, Stroke.

[4]  J. Slattery,et al.  Equivalence of Measurements of Carotid Stenosis: A Comparison of Three Methods on 1001 Angiograms , 1994, Stroke.

[5]  C. Yuan,et al.  Discriminating Carotid Atherosclerotic Lesion Severity by Luminal Stenosis and Plaque Burden: A Comparison Utilizing High-Resolution Magnetic Resonance Imaging at 3.0 Tesla , 2011, Stroke.

[6]  C. Yuan,et al.  MR Carotid Plaque Imaging and Contrast-Enhanced MR Angiography Identifies Lesions Associated with Recent Ipsilateral Thromboembolic Symptoms: An In Vivo Study at 3T , 2010, American Journal of Neuroradiology.

[7]  G. Tomaselli,et al.  Letter by Tomaselli and Holmes regarding article, "2011 ASA/ACCF/AHA/AANN/AANS/ACR/CNS/SAIP/SCAI/SIR/SNIS/SVM/SVS guideline on the management of patients with extracranial carotid and vertebral artery disease". , 2012, Circulation.

[8]  M. Eliasziw,et al.  Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery , 2004, The Lancet.

[9]  Navneet Singh,et al.  Late stage complicated atheroma in low-grade stenotic carotid disease: MR imaging depiction--prevalence and risk factors. , 2011, Radiology.

[10]  Kazumichi Yoshida,et al.  Symptomatic low-grade carotid stenosis with intraplaque hemorrhage and expansive arterial remodeling is associated with a high relapse rate refractory to medical treatment. , 2012, Neurosurgery.

[11]  J. Halperin,et al.  2011 ASA/ACCF/AHA/AANN/AANS/ACR/ASNR/CNS/SAIP/SCAI/SIR/SNIS/SVM/SVS guideline on the management of patients with extracranial carotid and vertebral artery disease: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guideline , 2011, Journal of the American College of Cardiology.

[12]  Kazumichi Yoshida,et al.  Association Between Carotid Atherosclerosis Plaque With High Signal Intensity on T1-Weighted Imaging and Subsequent Ipsilateral Ischemic Events , 2011, Neurosurgery.

[13]  Dorothee P Auer,et al.  Carotid intraplaque hemorrhage detected by magnetic resonance imaging predicts embolization during carotid endarterectomy. , 2007, Journal of vascular surgery.

[14]  Chun Yuan,et al.  Presence of Intraplaque Hemorrhage Stimulates Progression of Carotid Atherosclerotic Plaques: A High-Resolution Magnetic Resonance Imaging Study , 2005, Circulation.

[15]  J. Bland,et al.  Restenosis after carotid angioplasty, stenting, or endarterectomy in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS). , 2005, Stroke.

[16]  Sean Symons,et al.  In vivo 3D high-spatial-resolution MR imaging of intraplaque hemorrhage. , 2008, Radiology.

[17]  Wouter Peeters,et al.  Composition of Carotid Atherosclerotic Plaque Is Associated With Cardiovascular Outcome: A Prognostic Study , 2010, Circulation.

[18]  A. Naylor,et al.  What is the current status of invasive treatment of extracranial carotid artery disease? , 2011, Stroke.

[19]  Chun Yuan,et al.  Association Between Carotid Plaque Characteristics and Subsequent Ischemic Cerebrovascular Events: A Prospective Assessment With MRI—Initial Results , 2006, Stroke.

[20]  D. Calvet,et al.  Relationships Between Recent Intraplaque Hemorrhage and Stroke Risk Factors in Patients With Carotid Stenosis: The HIRISC Study , 2012, Arteriosclerosis, thrombosis, and vascular biology.

[21]  J. Gillard,et al.  In vivo MRI-based 3D mechanical stress-strain profiles of carotid plaques with juxtaluminal plaque haemorrhage: an exploratory study for the mechanism of subsequent cerebrovascular events. , 2011, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[22]  Dorothee P Auer,et al.  Brain white matter hyperintensities are associated with carotid intraplaque hemorrhage. , 2008, Radiology.

[23]  E. Falk.  Morphologic features of unstable atherothrombotic plaques underlying acute coronary syndromes. , 1989, The American journal of cardiology.

[24]  Alfons G H Kessels,et al.  In vivo detection of hemorrhage in human atherosclerotic plaques with magnetic resonance imaging , 2004, Journal of magnetic resonance imaging : JMRI.

[25]  Dorothee P Auer,et al.  Carotid Intraplaque Hemorrhage Predicts Recurrent Symptoms in Patients With High-Grade Carotid Stenosis , 2007, Stroke.

[26]  Renu Virmani,et al.  Intraplaque hemorrhage and progression of coronary atheroma. , 2003, The New England journal of medicine.

[27]  J. Gladman,et al.  Plaque hemorrhage is a marker of thromboembolic activity in patients with symptomatic carotid disease. , 2011, Radiology.

[28]  R. Detrano,et al.  Carotid vulnerable lesions are related to accelerated recurrence for cerebral infarction magnetic resonance imaging study. , 2006, Academic radiology.

[29]  P. Rothwell,et al.  Population-based study of delays in carotid imaging and surgery and the risk of recurrent stroke , 2005, Neurology.

[30]  C. Yuan,et al.  Images in cardiovascular medicine. Serial high-spatial-resolution, multisequence magnetic resonance imaging studies identify fibrous cap rupture and penetrating ulcer into carotid atherosclerotic plaque. , 2006, Circulation.

[31]  Anne L. Martel,et al.  Characterization of Complicated Carotid Plaque With Magnetic Resonance Direct Thrombus Imaging in Patients With Cerebral Ischemia , 2003, Circulation.

[32]  Chun Yuan,et al.  Hemorrhage in the Atherosclerotic Carotid Plaque: A High-Resolution MRI Study , 2004, Stroke.

[33]  Anne L. Martel,et al.  Prevalence of Complicated Carotid Atheroma as Detected by Magnetic Resonance Direct Thrombus Imaging in Patients With Suspected Carotid Artery Stenosis and Previous Acute Cerebral Ischemia , 2003, Circulation.

[34]  M. E. Kooi,et al.  Carotid Plaques in Transient Ischemic Attack and Stroke Patients: One-Year Follow-up Study by Magnetic Resonance Imaging , 2010, Investigative radiology.

[35]  S. Gutnikov,et al.  Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison , 2007, The Lancet.

[36]  N. Laird,et al.  Meta-analysis in clinical trials. , 1986, Controlled clinical trials.

[37]  J. Halperin,et al.  2011 ASA/ACCF/AHA/AANN/AANS/ACR/ASNR/CNS/SAIP/SCAI/SIR/SNIS/SVM/SVS guideline on the management of patients with extracranial carotid and vertebral artery disease: executive summary. , 2011, Stroke.

[38]  Michael D Hill,et al.  Stenting versus endarterectomy for treatment of carotid-artery stenosis. , 2010, The New England journal of medicine.

[39]  N. Altaf,et al.  Magnetic resonance detected carotid plaque hemorrhage is associated with inflammatory features in symptomatic carotid plaques. , 2013, Annals of vascular surgery.

[40]  C. Yuan,et al.  Quantitative Evaluation of Carotid Plaque Composition by In Vivo MRI , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[41]  N. Altaf,et al.  Lower Prevalence of Carotid Plaque Hemorrhage in Women, and Its Mediator Effect on Sex Differences in Recurrent Cerebrovascular Events , 2012, PloS one.

[42]  M. Eliasziw,et al.  Analysis of pooled data from the randomised controlled trials of endarterectomy for symptomatic carotid stenosis , 2003, The Lancet.

[43]  John P. Mugler,et al.  Magnetic Resonance Imaging of Carotid Atherosclerotic Plaque in Clinically Suspected Acute Transient Ischemic Attack and Acute Ischemic Stroke , 2010, Circulation.

[44]  H. Markus,et al.  Asymptomatic Embolization Detected by Doppler Ultrasound Predicts Stroke Risk in Symptomatic Carotid Artery Stenosis , 2005, Stroke.

[45]  D. Gladstone,et al.  Moderate carotid artery stenosis: MR imaging-depicted intraplaque hemorrhage predicts risk of cerebrovascular ischemic events in asymptomatic men. , 2009, Radiology.

[46]  Dorothee Auer,et al.  Detection of intraplaque hemorrhage by magnetic resonance imaging in symptomatic patients with mild to moderate carotid stenosis predicts recurrent neurological events. , 2008, Journal of vascular surgery.

[47]  Gary Friday,et al.  2011 ASA/ACCF/AHA/AANN/AANS/ACR/ASNR/CNS/SAIP/SCAI/SIR/SNIS/SVM/SVS guideline on the management of patients with extracranial carotid and vertebral artery disease. , 2011, Stroke.

[48]  H. Markus,et al.  Doppler Embolic Signals in Cerebrovascular Disease and Prediction of Stroke Risk: A Systematic Review and Meta-Analysis , 2009, Stroke.

[49]  C. Yuan,et al.  Arterial remodeling in [corrected] subclinical carotid artery disease. , 2009, JACC. Cardiovascular imaging.

[50]  A. Buchan,et al.  Early risk of stroke after a transient ischemic attack in patients with internal carotid artery disease , 2004, Canadian Medical Association Journal.