Large‐scale DNA microarray analysis of atopic skin lesions shows overexpression of an epidermal differentiation gene cluster in the alternative pathway and lack of protective gene expression in the cornified envelope

Background  Atopic dermatitis (AD)‐specific genes have not yet been clarified.

[1]  Tomas Ganz,et al.  Endogenous antimicrobial peptides and skin infections in atopic dermatitis. , 2002, The New England journal of medicine.

[2]  G. Abecasis,et al.  Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci , 2001, Nature Genetics.

[3]  Claus W Heizmann,et al.  S100 proteins: structure, functions and pathology. , 2002, Frontiers in bioscience : a journal and virtual library.

[4]  A. Ishida-Yamamoto,et al.  Elafin, a secretory protein, is cross-linked into the cornified cell envelopes from the inside of psoriatic keratinocytes. , 2002, The Journal of investigative dermatology.

[5]  M. Jackson,et al.  Gene expression profiles of laser-captured adjacent neuronal subtypes , 1999, Nature Medicine.

[6]  A. Bowcock,et al.  Insights into psoriasis and other inflammatory diseases from large-scale gene expression studies. , 2001, Human molecular genetics.

[7]  J. Celis,et al.  Identification of proteins that are abnormally regulated in differentiated cultured human keratinocytes , 1995, Electrophoresis.

[8]  R. Hay,et al.  The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis. III. Independent hospital validation , 1994, The British journal of dermatology.

[9]  P. Steinert,et al.  The Proteins Elafin, Filaggrin, Keratin Intermediate Filaments, Loricrin, and Small Proline-rich Proteins 1 and 2 Are Isodipeptide Cross-linked Components of the Human Epidermal Cornified Cell Envelope (*) , 1995, The Journal of Biological Chemistry.

[10]  E. Fuchs,et al.  Epidermal differentiation: the bare essentials , 1990, The Journal of cell biology.

[11]  G. Darmstadt,et al.  Keratinocyte Expression of Human β Defensin 2 following Bacterial Infection: Role in Cutaneous Host Defense , 2003, Clinical Diagnostic Laboratory Immunology.

[12]  R. Pfundt,et al.  Transcriptional regulation of the elafin gene in human keratinocytes. , 2003, The Journal of investigative dermatology.

[13]  C. Murray Tumour dormancy: not so sleepy after all , 1995, Nature Medicine.

[14]  J. Travers,et al.  Distinct patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis: a gene microarray analysis. , 2003, The Journal of allergy and clinical immunology.