Role of pharmacokinetics in drug dosage adjustment. I. Pharmacologic effect kinetics and apparent volume of distribution of digoxin.

[1]  A. Redfors.  The effect of different digoxin doses on subjective symptoms and physical working capacity in patients with atrial fibrillation. , 2009, Acta Medica Scandinavica.

[2]  R. Jelliffe,et al.  A nomogram for digoxin therapy. , 1974, The American journal of medicine.

[3]  M. Gibaldi,et al.  Drug elimination and apparent volume of distribution in multicompartment systems. , 1972, Journal of pharmaceutical sciences.

[4]  M. Gibaldi,et al.  Drug distribution and renal failure. , 1972, The Journal of clinical pharmacology and new drugs.

[5]  C. Parker,et al.  Radioimmunoassay for digoxin. Technic and clinical application. , 1971, The American journal of medicine.

[6]  J. Doherty.  Digitalis serum levels: clinical use. , 1971, Annals of internal medicine.

[7]  M. Murphy,et al.  New information regarding digitalis metabolism. , 1971, Chest.

[8]  K. Taubert,et al.  Relationship of Plasma Digitoxin and Digoxin to Cardiac Response Following Intravenous Digitalization in Man , 1970, Circulation.

[9]  E. Haber,et al.  Digoxin intoxication: the relationship of clinical presentation to serum digoxin concentration. , 1970, The Journal of clinical investigation.

[10]  P. Binnion,et al.  The distribution of 3H-digoxin in normal and acutely hyperkalaemic dogs. , 1970, Cardiovascular research.

[11]  E. Haber,et al.  Determination of therapeutic and toxic serum digoxin concentrations by radioimmunoassay. , 1969, The New England journal of medicine.

[12]  R. Jelliffe.  Administration of digoxin. , 1969, Diseases of the chest.

[13]  M. Gibaldi,et al.  Relationship Between Drug Concentration in Plasma or Serum and Amount of Drug in the Body , 1969 .

[14]  S. Dutta,et al.  The uptake and binding of six radiolabeled cardiac glycosides by guinea-pig hearts and by isolated sarcoplasmic reticulum. , 1968, The Journal of pharmacology and experimental therapeutics.

[15]  R. Jelliffe.  An improved method of digoxin therapy. , 1968, Annals of internal medicine.

[16]  Doherty Je.  The Clinical Pharmacology of Digitalis Glycosides: A Review , 1968, The American journal of the medical sciences.

[17]  S. Kaihara,et al.  Studies with tritiated digoxin in renal failure and diabetes mellitus. , 1967, Japanese heart journal.

[18]  J. Doherty,et al.  Studies with Tritiated Digoxin in Anephric Human Subjects , 1967, Circulation.

[19]  A. Salel,et al.  The metabolism of tritiated digoxin in renal insufficiency in dogs and man. , 1966, The Journal of pharmacology and experimental therapeutics.

[20]  A. Weissler,et al.  Assay of digitalis glycosides in man , 1966 .

[21]  P. Ongley,et al.  The distribution and excretion of tritiated substances in experimental animals following the administration of digoxin-3H. , 1966, The Journal of laboratory and clinical medicine.

[22]  W. Nelp,et al.  RELATIONSHIP OF THE EXCRETION OF TRITIATED DIGOXIN TO RENAL FUNCTION , 1966, The American journal of the medical sciences.

[23]  A. Schott,et al.  Observations on Digitalis Intoxication—A Plea , 1964, Postgraduate medical journal.

[24]  J. Doherty,et al.  STUDIES WITH TRITIATED DIGOXIN IN RENAL FAILURE. , 1964, The American journal of medicine.

[25]  F. Marcus,et al.  THE METABOLISM OF DIGOXIN IN NORMAL SUBJECTS. , 1964, The Journal of pharmacology and experimental therapeutics.

[26]  J. Doherty,et al.  Studies with tritiated digoxin in human subjects after intravenous administration. , 1962, American heart journal.

[27]  F. Wasserman,et al.  Observations on digitalis intoxication. , 1961, Archives of internal medicine.

[28]  D. Harrison,et al.  The relation between myocardial 3 H-digoxin concentration and its hemodynamic effects. , 1972, The American journal of cardiology.

[29]  R. Kalaba,et al.  A computer program for digitalis dosage regimens , 1970 .

[30]  M. Rowland,et al.  Concept of a volume of distribution and possible errors in evaluation of this parameter. , 1968, Journal of pharmaceutical sciences.

[31]  M. Rowland,et al.  Shortcomings in pharmacokinetic analysis by conceiving the body to exhibit properties of a single compartment. , 1968, Journal of pharmaceutical sciences.

[32]  J. Doherty,et al.  The distribution and concentration of tritiated digoxin in human tissues. , 1967, Annals of internal medicine.

[33]  R. Jelliffe.  A mathematical analysis of digitalis kinetics in patients with normal and reduced renal function , 1967 .