Glucose biosensor based on multisegment nanowires exhibiting reversible magnetic control.

We describe the amperometric detection of glucose using oriented nanowires with magnetic switching of the bioelectrochemical process. The fabrication process of the nanowires was prepared through controlled nucleation and growth during a stepwise electrochemical deposition, and it was characterized using scanning electron microscopy. Cyclic voltammetry and amperometry were used to study the magnetoswitchable property; this control was accomplished by changing the surface orientation of nanowires. Under the optimal condition, the amperometric response was also linear up to a glucose concentration of 0.1-16.0 mmol L(-1) with a sensitivity of 81 μA mM(-1). The detection limit was estimated for 4.8×10(-8) mol L(-1), defined from a signal/noise ratio of 3. It also exhibits good reproducibility and high selectivity with insignificant interference from ascorbic acid, acetoaminophen, and uric acid. The resulting biosensor was applied to detect the blood sugar in human serum samples without any pretreatment, and the results were comparatively in agreement with the clinical assay.

[1]  Jiaoqiang Zhang,et al.  Ni(II)–quercetin complex modified multiwall carbon nanotube ionic liquid paste electrode and its electrocatalytic activity toward the oxidation of glucose , 2009 .

[2]  M. Wooten,et al.  On the direct electron transfer, sensing, and enzyme activity in the glucose oxidase/carbon nanotubes system. , 2014, Analytical chemistry.

[3]  Ashok Mulchandani,et al.  Nanowire‐Based Electrochemical Biosensors , 2006 .

[4]  Yixuan Chen,et al.  Precisely Defined Heterogeneous Conducting Polymer Nanowire Arrays – Fabrication and Chemical Sensing Applications , 2009 .

[5]  Saroja Mantha,et al.  Renewable nanocomposite layer-by-layer assembled catalytic interfaces for biosensing applications. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[6]  Masato Saito,et al.  Nanomaterial-based electrochemical biosensors for medical applications , 2008 .

[7]  J. Luong,et al.  Direct electrochemistry of horseradish peroxidase immobilized on a monolayer modified nanowire array electrode. , 2010, Biosensors & bioelectronics.

[8]  Xuemei Wang,et al.  ZnO/Cu nanocomposite: a platform for direct electrochemistry of enzymes and biosensing applications. , 2012, Langmuir : the ACS journal of surfaces and colloids.

[9]  M. Cabral,et al.  Nanogravimetric study of lead underpotential deposition on selenium thin films as a semiconductor alloy formation procedure , 2012 .

[10]  E. Wang,et al.  Gold nanowire assembling architecture for H2O2 electrochemical sensor. , 2009, Talanta.

[11]  Joseph Wang,et al.  "Nanofingers" based on binary gold-polypyrrole nanowires. , 2008, Small.

[12]  Joseph Wang.  Biomolecule-functionalized nanowires: from nanosensors to nanocarriers. , 2009, Chemphyschem : a European journal of chemical physics and physical chemistry.

[13]  S. Minko,et al.  Plasmonic nanobiosensor with chain reaction amplification mechanism. , 2014, Chemistry.

[14]  Joseph Wang.  Nanomaterial-based electrochemical biosensors. , 2005, The Analyst.

[15]  Angelo Visconti,et al.  Advances in biosensor development based on integrating nanotechnology and applied to food-allergen management , 2013 .

[16]  Federica Valentini,et al.  Magnetic tuning of the electrochemical reactivity through controlled surface orientation of catalytic nanowires. , 2006, Journal of the American Chemical Society.

[17]  B. Jena,et al.  Electrochemical biosensor based on integrated assembly of dehydrogenase enzymes and gold nanoparticles. , 2006, Analytical chemistry.

[18]  Peixiang Cai,et al.  A sensitive nonenzymatic glucose sensor in alkaline media with a copper nanocluster/multiwall carbon nanotube-modified glassy carbon electrode. , 2007, Analytical biochemistry.

[19]  A. Offenhäusser,et al.  Bioelectrochemical systems with oleylamine-stabilized gold nanostructures and horseradish peroxidase for hydrogen peroxide sensor. , 2014, Biosensors & bioelectronics.

[20]  Jinbo Zhu,et al.  Preparation of gold nanowires and its application in glucose biosensing , 2013 .

[21]  Shaojun Dong,et al.  Nanocomposite based on depositing platinum nanostructure onto carbon nanotubes through a one-pot, facile synthesis method for amperometric sensing. , 2009, Talanta.

[22]  Jun Yang,et al.  Shewanella oneidensis MR-1 bacterial nanowires exhibit p-type, tunable electronic behavior. , 2013, Nano letters.

[23]  S. Yoon,et al.  Experimental study of sensitivity enhancement in surface plasmon resonance biosensors by use of periodic metallic nanowires. , 2007, Optics letters.

[24]  Long Lin,et al.  Self-powered magnetic sensor based on a triboelectric nanogenerator. , 2012, ACS nano.

[25]  Joseph Wang,et al.  Adaptive orientation of multifunctional nanowires for magnetic control of bioelectrocatalytic processes. , 2007, Angewandte Chemie.

[26]  Hai-Long Wu,et al.  Nano nickel oxide modified non-enzymatic glucose sensors with enhanced sensitivity through an electrochemical process strategy at high potential. , 2011, Biosensors & bioelectronics.

[27]  Yue Zhang,et al.  Enzyme-coated single ZnO nanowire FET biosensor for detection of uric acid , 2013 .

[28]  M. Willander,et al.  Development of a disposable potentiometric antibody immobilized ZnO nanotubes based sensor for the detection of C-reactive protein , 2012 .

[29]  Mojtaba Shamsipur,et al.  Highly improved electrooxidation of glucose at a nickel(II) oxide/multi-walled carbon nanotube modified glassy carbon electrode. , 2010, Bioelectrochemistry.

[30]  Alberto Escarpa,et al.  Copper nanowires immobilized on the boards of microfluidic chips for the rapid and simultaneous diagnosis of galactosemia diseases in newborn urine samples. , 2013, Analytical chemistry.

[31]  C. Pundir,et al.  Construction and application of an amperometric uric acid biosensor based on covalent immobilization of uricase on iron oxide nanoparticles/chitosan-g-polyaniline composite film electrodeposited on Pt electrode , 2014 .

[32]  Shouzhuo Yao,et al.  Amperometric glucose biosensor based on boron-doped carbon nanotubes modified electrode. , 2008, Talanta.