Against all odds: anti-IgE for intrinsic asthma?

For many years, pathogenetic concepts and the results of clinical trials supported the view that anti-IgE treatment is specifically effective in allergic asthma. However, there is now growing clinical and mechanistic evidence suggesting that treatment with the anti-IgE antibody omalizumab can be effective in patients with intrinsic asthma. Therefore, large and well-controlled clinical trials with anti-IgE are urgently warranted in patients with intrinsic asthma. In addition, there is a need to find new biomarkers which can identify patients with asthma who respond to anti-IgE treatment.

[1]  M. Humbert,et al.  A proof-of-concept, randomized, controlled trial of omalizumab in patients with severe, difficult-to-control, nonatopic asthma. , 2013, Chest.

[2]  W. Busse,et al.  Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study. , 2013, American journal of respiratory and critical care medicine.

[3]  C. Picado,et al.  Effects of Omalizumab in Non-Atopic Asthma: Results from a Spanish Multicenter Registry , 2013, The Journal of asthma : official journal of the Association for the Care of Asthma.

[4]  J. Virchow,et al.  Plasmacytoid dendritic cells in allergic asthma and the role of inhaled corticosteroid treatment , 2013, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[5]  A. Pritchard,et al.  The plasmacytoid dendritic cell: at the cross-roads in asthma , 2013, European Respiratory Journal.

[6]  J. Benichou,et al.  Does omalizumab make a difference to the real-life treatment of asthma exacerbations?: Results from a large cohort of patients with severe uncontrolled asthma. , 2013, Chest.

[7]  I. Pavord,et al.  Omalizumab: NICE to USE you, to LOSE you NICE , 2012, Thorax.

[8]  E. Gelfand.  Intravenous immune globulin in autoimmune and inflammatory diseases. , 2012, The New England journal of medicine.

[9]  Christopher E Brightling,et al.  The relationship between clinical outcomes and medication adherence in difficult-to-control asthma , 2012, Thorax.

[10]  C. Bachert,et al.  Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma. , 2012, The Journal of allergy and clinical immunology.

[11]  D. Renard,et al.  Omalizumab decreases IgE production in patients with allergic (IgE-mediated) asthma; PKPD analysis of a biomarker, total IgE. , 2011, British journal of clinical pharmacology.

[12]  C. Pilette,et al.  Presence in sputum of functional dust mite-specific IgE antibodies in intrinsic asthma. , 2011, American journal of respiratory and critical care medicine.

[13]  A. Simonazzi,et al.  Long-term benefits of omalizumab in a patient with severe non-allergic asthma , 2011, Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology.

[14]  M. Humbert,et al.  Omalizumab-induced decrease of FcξRI expression in patients with severe allergic asthma. , 2010, Respiratory medicine.

[15]  L. Fabbri,et al.  Nonatopic children with multitrigger wheezing have airway pathology comparable to atopic asthma. , 2008, American journal of respiratory and critical care medicine.

[16]  J. Schroeder,et al.  Human blood dendritic cells from allergic subjects have impaired capacity to produce interferon‐α via toll‐like receptor 9 , 2008, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[17]  J. Virchow.  Chapter 89. Intrinsic Asthma , 2008 .

[18]  W. Luttmann,et al.  Airway dendritic cell phenotypes in inflammatory diseases of the human lung , 2007, European Respiratory Journal.

[19]  W. Luttmann,et al.  Dendritic cell subsets in human bronchoalveolar lavage fluid after segmental allergen challenge , 2006, Thorax.

[20]  J. Schroeder,et al.  TLR9- and FcεRI-Mediated Responses Oppose One Another in Plasmacytoid Dendritic Cells by Down-Regulating Receptor Expression1 , 2005, The Journal of Immunology.

[21]  J. Bousquet,et al.  The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation. , 2005, The Journal of allergy and clinical immunology.

[22]  S. Durham,et al.  Local expression of ϵ germline gene transcripts and RNA for the ϵ heavy chain of IgE in the bronchial mucosa in atopic and nonatopic asthma , 2001 .

[23]  M. Humbert,et al.  Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4), and C-C chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (Intrinsic) asthmatics. , 1999, Journal of immunology.

[24]  S. Durham,et al.  Membrane-bound and soluble alpha IL-5 receptor mRNA in the bronchial mucosa of atopic and nonatopic asthmatics. , 1997, American journal of respiratory and critical care medicine.

[25]  S. Durham,et al.  IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity. , 1996, American journal of respiratory and critical care medicine.

[26]  S. Durham,et al.  High-affinity IgE receptor (FcepsilonRI)-bearing cells in bronchial biopsies from atopic and nonatopic asthma. , 1996, American journal of respiratory and critical care medicine.

[27]  J. Virchow,et al.  Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. , 1992, The American review of respiratory disease.

[28]  F. M. Rackemann.  A CLINICAL STUDY OF ONE HUNDRED AND FIFTY CASES OF BRONCHIAL ASTHMA , 1918 .

[29]  Y. Gon,et al.  Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma , 2013 .

[30]  D. Postma,et al.  Beneficial effects of treatment with anti-IgE antibodies (Omalizumab) in a patient with severe asthma and negative skin-prick test results. , 2011, Chest.

[31]  Alexander Rokitansky,et al.  Thorax , 2009, Pediatric Surgery Digest.

[32]  S. Durham,et al.  Local expression of epsilon germline gene transcripts and RNA for the epsilon heavy chain of IgE in the bronchial mucosa in atopic and nonatopic asthma. , 2001, The Journal of allergy and clinical immunology.

[33]  C. E. Kossmann.  Intrinsic asthma. , 1976, Journal of the Tennessee Medical Association.