Genetic Environment of Acquired blaACC-1 β-Lactamase Gene in Enterobacteriaceae Isolates

ABSTRACT We studied the genetic organization of blaACC-1 in 14 isolates of Enterobacteriaceae from France, Tunisia, and Germany. In a common ancestor, ISEcp1 was likely involved in the mobilization of this gene from the Hafnia alvei chromosome to a plasmid. Other genetic events involving insertion sequences (particularly IS26), transposons (particularly Tn1696), or sulI-type integrons have occurred, leading to complex genetic environments.

[1]  G. Arlet,et al.  Emergence of DHA-1-Producing Klebsiella spp. in the Parisian Region: Genetic Organization of the ampC and ampR Genes Originating from Morganella morganii , 2006, Antimicrobial Agents and Chemotherapy.

[2]  E. Bingen,et al.  In Vivo Transfer of Plasmid-Encoded ACC-1 AmpC from Klebsiella pneumoniae to Escherichia coli in an Infant and Selection of Impermeability to Imipenem in K. pneumoniae , 2005, Antimicrobial Agents and Chemotherapy.

[3]  F. Aarestrup,et al.  beta-Lactamases among extended-spectrum beta-lactamase (ESBL)-resistant Salmonella from poultry, poultry products and human patients in The Netherlands. , 2005, The Journal of antimicrobial chemotherapy.

[4]  J. Gaillard,et al.  Spread of a Klebsiella pneumoniae Strain Producing a Plasmid- Mediated ACC-1 AmpC β-Lactamase in a Teaching Hospital Admitting Disabled Patients , 2005, Antimicrobial Agents and Chemotherapy.

[5]  M. Giménez,et al.  Escherichia coli Producing an ACC-1 Class C β-Lactamase Isolated in Barcelona, Spain , 2005, Antimicrobial Agents and Chemotherapy.

[6]  P. Nordmann,et al.  Insertion Sequence ISEcp1B Is Involved in Expression and Mobilization of a blaCTX-M β-Lactamase Gene , 2003, Antimicrobial Agents and Chemotherapy.

[7]  G. Arlet,et al.  Molecular Epidemiology and Characterization of Plasmid-Encoded β-Lactamases Produced by Tunisian Clinical Isolates of Salmonella enterica Serotype Mbandaka Resistant to Broad-Spectrum Cephalosporins , 2003, Journal of Clinical Microbiology.

[8]  P. Courvalin,et al.  ColE1-Like Plasmid pIP843 of Klebsiella pneumoniae Encoding Extended-Spectrum β-Lactamase CTX-M-17 , 2002, Antimicrobial Agents and Chemotherapy.

[9]  George A. Jacoby,et al.  Plasmid-Determined AmpC-Type β-Lactamases , 2002, Antimicrobial Agents and Chemotherapy.

[10]  G. Arlet,et al.  Mise en évidence de la céphalosporinase plasmidique ACC-1 dans différentes entérobactéries (Klebsiella pneumoniae, Proteus mirabilis, Salmonella) isolées dans un hôpital tunisien (Sfax 1997–2000) , 2002 .

[11]  A. Philippon,et al.  [Identification of plasmid-encoded cephalosporinase ACC-1 among various enterobacteria (Klebsiella pneumoniae, Proteus mirabilis, Salmonella) isolated from a Tunisian hospital (Sfax 997-2000)]. , 2002, Pathologie-biologie.

[12]  J. Herrmann,et al.  Plasmid-Mediated Rifampin Resistance Encoded by anarr-2-Like Gene Cassette in Klebsiella pneumoniae Producing an ACC-1 Class C β-Lactamase , 2001, Antimicrobial Agents and Chemotherapy.

[13]  P. Nordmann,et al.  Characterization of In53, a Class 1 Plasmid- and Composite Transposon-Located Integron of Escherichia coli Which Carries an Unusual Array of Gene Cassettes , 2001, Journal of bacteriology.

[14]  Amersham Pharmacia Biotech.  Plasmid-Mediated Rifampin Resistance Encoded by an arr-2-Like Gene Cassette in Klebsiella pneumoniae Producing an ACC-1 Class C -Lactamase , 2001 .

[15]  P. Nordmann,et al.  Plasmid-Mediated Cephalosporinase ACC-1 in Clinical Isolates of Proteus mirabilis and Escherichia coli , 2000, European Journal of Clinical Microbiology and Infectious Diseases.

[16]  J. Herrmann,et al.  Outbreak of Klebsiella pneumoniae producing transferable AmpC-type beta-lactamase (ACC-1) originating from Hafnia alvei. , 2000, FEMS microbiology letters.

[17]  U. Ullmann,et al.  A Novel Type of AmpC β-Lactamase, ACC-1, Produced by a Klebsiella pneumoniae Strain Causing Nosocomial Pneumonia , 1999, Antimicrobial Agents and Chemotherapy.

[18]  J. Lucet,et al.  Clinical and bacteriologic epidemiology of extended-spectrum β-lactamase-producing strains of Klebsiella pneumoniae in a medical intensive care unit , 1998 .

[19]  D H Persing,et al.  Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing , 1995, Journal of clinical microbiology.