Near-infrared persistent luminescence hollow mesoporous nanospheres for drug delivery and in vivo renewable imaging.

The design and fabrication of trackable drug carriers is of great importance for tracking the route of drug delivery in vivo. Here, we report novel stick-shell structure, near-infrared (NIR) persistent luminescence hollow mesoporous (ZnGa2O4:Cr3+@HMS) nanospheres. Due to the hollow mesoporous SiO2 skeleton structure, the prepared nanospheres possess a high Brunauer-Emmett-Teller (BET) surface area of 514 m2 g-1 and a pore volume of 1.16 cm3 g-1, which make these nanospheres ideal drug carriers for drug loading and sustained release. In addition, these nanospheres exhibit strong NIR emission at 696 nm, and their NIR persistent luminescence can persist for more than three hours after excitation. Thus, we can realize autofluorescence-free and long-term tracking of the transport routes of drug carriers by using the exceptional properties of NIR persistent luminescence of nanospheres. More importantly, we found that the NIR persistent luminescence of ZnGa2O4:Cr3+@HMS nanospheres can be repeatedly excited by a 655 nm LED lamp. Thus, the drug transport route can be tracked for an extended time with high sensitivity in deep tissue via the method of in situ repeatable excitation. Our results indicate that the ZnGa2O4:Cr3+@HMS nanospheres combine the advantages of high drug storage capacity and excellent NIR persistent luminescence, and they show potential for application as trackable drug carriers.

[1]  Xia Sun,et al.  One-step synthesis of amino-functionalized ultrasmall near infrared-emitting persistent luminescent nanoparticles for in vitro and in vivo bioimaging. , 2016, Nanoscale.

[2]  B. Viana,et al.  ZnGa2O4:Cr3+: a new red long-lasting phosphor with high brightness. , 2011, Optics express.

[3]  Emmanuel P. Giannelis,et al.  Facile and Scalable Synthesis of Monodispersed Spherical Capsules with a Mesoporous Shell , 2010 .

[4]  Q. Zhang,et al.  Mesoporous nanoparticles Gd2O3@mSiO2/ZnGa2O4:Cr3+,Bi3+ as multifunctional probes for bioimaging. , 2016, Journal of materials chemistry. B.

[5]  Feng Liu,et al.  Photostimulated near-infrared persistent luminescence as a new optical read-out from Cr3+-doped LiGa5O8 , 2013, Scientific Reports.

[6]  N. Zheng,et al.  Self-templating synthesis of hollow mesoporous silica and their applications in catalysis and drug delivery. , 2013, Nanoscale.

[7]  Didier Gourier,et al.  The in vivo activation of persistent nanophosphors for optical imaging of vascularization, tumours and grafted cells. , 2014, Nature materials.

[8]  Jun Lin,et al.  Functionalized mesoporous silica materials for controlled drug delivery. , 2012, Chemical Society reviews.

[9]  Taeghwan Hyeon,et al.  Multifunctional uniform nanoparticles composed of a magnetite nanocrystal core and a mesoporous silica shell for magnetic resonance and fluorescence imaging and for drug delivery. , 2008, Angewandte Chemie.

[10]  Hong-Lee Park,et al.  Optical and structural properties of nanosized ZnGa2O4:Cr3+ phosphor , 2004 .

[11]  Junpeng Shi,et al.  Multifunctional near infrared-emitting long-persistence luminescent nanoprobes for drug delivery and targeted tumor imaging. , 2015, Biomaterials.

[12]  Yan Hu,et al.  Intracellular redox-activated anticancer drug delivery by functionalized hollow mesoporous silica nanoreservoirs with tumor specificity. , 2014, Biomaterials.

[13]  C. Yeh,et al.  Shell-by-shell synthesis of multi-shelled mesoporous silica nanospheres for optical imaging and drug delivery. , 2011, Biomaterials.

[14]  Yu Chen,et al.  Core/shell structured hollow mesoporous nanocapsules: a potential platform for simultaneous cell imaging and anticancer drug delivery. , 2010, ACS nano.

[15]  Meng Sun,et al.  Persistent luminescent nanoparticles for super-long time in vivo and in situ imaging with repeatable excitation , 2014 .

[16]  Jun Lin,et al.  Lutecium fluoride hollow mesoporous spheres with enhanced up-conversion luminescent bioimaging and light-triggered drug release by gold nanocrystals. , 2014, ACS applied materials & interfaces.

[17]  M. C. Mancini,et al.  Bioimaging: second window for in vivo imaging. , 2009, Nature nanotechnology.

[18]  Junpeng Shi,et al.  Magnetic, long persistent luminescent and mesoporous nanoparticles as trackable transport drug carriers. , 2015, Journal of materials chemistry. B.

[19]  Qiang Zhao,et al.  Functional near infrared-emitting Cr3+/Pr3+ co-doped zinc gallogermanate persistent luminescent nanoparticles with superlong afterglow for in vivo targeted bioimaging. , 2013, Journal of the American Chemical Society.

[20]  Didier Gourier,et al.  Nanoprobes with near-infrared persistent luminescence for in vivo imaging , 2007, Proceedings of the National Academy of Sciences.

[21]  Dongmei Yang,et al.  Hollow structured upconversion luminescent NaYF₄:Yb³⁺, Er³⁺ nanospheres for cell imaging and targeted anti-cancer drug delivery. , 2013, Biomaterials.

[22]  Feng Liu,et al.  Photostimulable Near-Infrared Persistent Luminescent Nanoprobes for Ultrasensitive and Longitudinal Deep-Tissue Bio-Imaging , 2014, Theranostics.

[23]  Didier Gourier,et al.  Storage of Visible Light for Long-Lasting Phosphorescence in Chromium-Doped Zinc Gallate , 2014 .

[24]  F. Lin,et al.  Hollow mesoporous hydroxyapatite nanoparticles (hmHANPs) with enhanced drug loading and pH-responsive release properties for intracellular drug delivery. , 2013, Journal of materials chemistry. B.

[25]  Zhengwei Pan,et al.  Sunlight-activated long-persistent luminescence in the near-infrared from Cr(3+)-doped zinc gallogermanates. , 2011, Nature materials.

[26]  Linlin Li,et al.  Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery , 2012, Advanced materials.

[27]  B. Bal,et al.  Hollow hydroxyapatite microspheres: a novel bioactive and osteoconductive carrier for controlled release of bone morphogenetic protein-2 in bone regeneration. , 2013, Acta biomaterialia.

[28]  Yang Li,et al.  Long persistent phosphors--from fundamentals to applications. , 2016, Chemical Society reviews.

[29]  M. Vallet‐Regí,et al.  A New Property of MCM-41: Drug Delivery System , 2001 .

[30]  Jinlong Zhang,et al.  Superbright multifluorescent core-shell mesoporous nanospheres as trackable transport carrier for drug. , 2011, ACS nano.