Thoracic dual energy CT: acquisition protocols, current applications and future developments.

Thanks to a simultaneous acquisition at high and low kilovoltage, dual energy computed tomography (DECT) can achieve material-based decomposition (iodine, water, calcium, etc.) and reconstruct images at different energy levels (40 to 140keV). Post-processing uses this potential to maximise iodine detection, which elicits demonstrated added value for chest imaging in acute and chronic embolic diseases (increases the quality of the examination and identifies perfusion defects), follow-up of aortic endografts and detection of contrast uptake in oncology. In CT angiography, these unique features are taken advantage of to reduce the iodine load by more than half. This review article aims to set out the physical basis for the technology, the acquisition and post-processing protocols used, its proven advantages in chest pathologies, and to present future developments.

[1]  S. Schoenberg,et al.  Prognostic value of perfusion defect volume at dual energy CTA in patients with pulmonary embolism: correlation with CTA obstruction scores, CT parameters of right ventricular dysfunction and adverse clinical outcome. , 2012, European journal of radiology.

[2]  Marcel J W Greuter,et al.  Feasibility and accuracy of tissue characterization with dual source computed tomography. , 2012, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

[3]  Thomas Flohr,et al.  Lung perfusion with dual-energy multidetector-row CT (MDCT): feasibility for the evaluation of acute pulmonary embolism in 117 consecutive patients. , 2008, Academic radiology.

[4]  A. Gervaise,et al.  CT dose optimisation and reduction in osteoarticular disease. , 2013, Diagnostic and interventional imaging.

[5]  B. Krauss,et al.  Imaging of ventilation with dual-energy CT during breath hold after single vital-capacity inspiration of stable xenon. , 2012, Radiology.

[6]  J. Seo,et al.  Analysis of perfusion defects by causes other than acute pulmonary thromboembolism on contrast-enhanced dual-energy CT in consecutive 537 patients. , 2012, European journal of radiology.

[7]  M. Macari,et al.  Dual-energy computed tomography imaging of the aorta after endovascular repair of abdominal aortic aneurysm. , 2010, Seminars in ultrasound, CT, and MR.

[8]  K Nikolaou,et al.  Dual Energy CT lung perfusion imaging--correlation with SPECT/CT. , 2012, European journal of radiology.

[9]  C. Fink,et al.  Adenosine-stress dynamic real-time myocardial perfusion CT and adenosine-stress first-pass dual-energy myocardial perfusion CT for the assessment of acute chest pain: initial results. , 2012, European journal of radiology.

[10]  Konstantin Nikolaou,et al.  Dual energy CT for the assessment of lung perfusion--correlation to scintigraphy. , 2008, European journal of radiology.

[11]  S. Schoenberg,et al.  Cost-effectiveness of substituting dual-energy CT for SPECT in the assessment of myocardial perfusion for the workup of coronary artery disease. , 2012, European journal of radiology.

[12]  J. Goo,et al.  Dual-energy CT: clinical applications in various pulmonary diseases. , 2010, Radiographics : a review publication of the Radiological Society of North America, Inc.

[13]  J. Remy,et al.  Single- and dual-source chest CT protocols: Levels of radiation dose in routine clinical practice. , 2012, Diagnostic and interventional imaging.

[14]  C. Roy,et al.  How far can we reduce the iodine load at CT pulmonary angiography using dual-energy : a prospective study on 40 patients. , 2013 .

[15]  Xiaofeng Yang,et al.  Pulmonary enhancement imaging with dual energy CT for the detection of pulmonary embolism in a rabbit model: comparison to perfusion planar scintigraphy, SPECT and SPECT-CT modalities. , 2011, Academic radiology.

[16]  J. Seo,et al.  Clinical utility of dual-energy CT in the evaluation of solitary pulmonary nodules: initial experience. , 2008, Radiology.

[17]  D. Gopalan,et al.  Dual-energy CT pulmonary angiography: a novel technique for assessing acute and chronic pulmonary thromboembolism. , 2009, Clinical radiology.

[18]  K Nikolaou,et al.  Dual-Energy CT Angiography of the Lung in Patients with Suspected Pulmonary Embolism: Initial Results , 2008, RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin.

[19]  B. Krauss,et al.  Dual energy computed tomography of lung nodules: differentiation of iodine and calcium in artificial pulmonary nodules in vitro. , 2011, European journal of radiology.

[20]  G. Bastarrika,et al.  Low radiation and low-contrast dose pulmonary CT angiography: Comparison of 80 kVp/60 ml and 100 kVp/80 ml protocols. , 2012, Clinical radiology.

[21]  T. Flohr,et al.  Pulmonary imaging using dual-energy CT, a role of the assessment of iodine and air distribution. , 2011, European journal of radiology.

[22]  J. Remy,et al.  Krypton ventilation imaging using dual-energy CT in chronic obstructive pulmonary disease patients: initial experience. , 2012, Radiology.

[23]  Joon Beom Seo,et al.  Xenon ventilation CT with a dual-energy technique of dual-source CT: initial experience. , 2008, Radiology.

[24]  M. Körner,et al.  Imaging of acute pulmonary embolism using a dual energy CT system with rapid kVp switching: initial results. , 2012, European journal of radiology.

[25]  Dual-energy CT can evaluate both hilar and mediastinal lymph nodes and lesion vascularity with a single scan at 60 seconds after contrast medium injection. , 2012, Academic radiology.

[26]  J. Remy,et al.  Thoracic applications of dual-source CT technology. , 2008, European journal of radiology.

[27]  R. Nelson,et al.  Dual-energy multidetector CT: how does it work, what can it tell us, and when can we use it in abdominopelvic imaging? , 2010, Radiographics : a review publication of the Radiological Society of North America, Inc.

[28]  T. Vogl,et al.  Dual-energy CT for the assessment of chronic myocardial infarction in patients with chronic coronary artery disease: comparison with 3-T MRI. , 2010, AJR. American journal of roentgenology.

[29]  J. Leipsic,et al.  Reduced iodine load at CT pulmonary angiography with dual-energy monochromatic imaging: comparison with standard CT pulmonary angiography--a prospective randomized trial. , 2012, Radiology.

[30]  Jiang Hsieh,et al.  Quantitative myocardial perfusion imaging using rapid kVp switch dual-energy CT: preliminary experience. , 2011, Journal of cardiovascular computed tomography.

[31]  Thomas Frauenfelder,et al.  Diagnostic performance of dual-energy CT for the detection of traumatic bone marrow lesions in the ankle: comparison with MR imaging. , 2012, Radiology.

[32]  Ting-Yim Lee,et al.  Quantitative myocardial CT perfusion: a pictorial review and the current state of technology development. , 2011, Journal of cardiovascular computed tomography.

[33]  Greta Toncheva,et al.  Dual energy versus single energy MDCT: measurement of radiation dose using adult abdominal imaging protocols. , 2009, Academic radiology.

[34]  J. Remy,et al.  Dual-energy CT angiography of chronic thromboembolic disease: can it help recognize links between the severity of pulmonary arterial obstruction and perfusion defects? , 2011, European journal of radiology.

[35]  Richard H Cohan,et al.  Dual-energy CT with single- and dual-source scanners: current applications in evaluating the genitourinary tract. , 2012, Radiographics : a review publication of the Radiological Society of North America, Inc.

[36]  Tust Techasith,et al.  Stress myocardial CT perfusion: an update and future perspective. , 2011, JACC. Cardiovascular imaging.

[37]  Borut Marincek,et al.  Endoleaks after endovascular abdominal aortic aneurysm repair: detection with dual-energy dual-source CT. , 2008, Radiology.

[38]  M. Reiser,et al.  Dual-energy lung perfusion computed tomography: a novel pulmonary functional imaging method. , 2010, Seminars in ultrasound, CT, and MR.

[39]  C. Leidecker,et al.  Dual-energy MDCT: comparison of pulmonary artery enhancement on dedicated CT pulmonary angiography, routine and low contrast volume studies. , 2011, European journal of radiology.

[40]  B. Ko,et al.  CT stress myocardial perfusion imaging using multidetector CT--A review. , 2011, Journal of cardiovascular computed tomography.

[41]  J. Pruvo Diagnostic and interventional imaging. , 2012, Diagnostic and Interventional Imaging.

[42]  S. Achenbach,et al.  Myocardial viability by dual-energy delayed enhancement computed tomography. , 2011, JACC. Cardiovascular imaging.

[43]  Sang Joon Park,et al.  Chronic obstructive pulmonary disease: quantitative and visual ventilation pattern analysis at xenon ventilation CT performed by using a dual-energy technique. , 2010, Radiology.