Dual-pulse nonlinear photoacoustic technique: a practical investigation.

The dual-pulse nonlinear photoacoustic technique is a recently developed technology based on temperature dependence of the Grüneisen parameter and involves consecutive excitations of biological tissue using two laser pulses with a short time delay. Here we review the principle of the technique and give a discussion about its technical aspects, including selection and combination of excitation laser wavelengths, determination of laser fluence, estimation of thermal relaxation function and probability of photoablation or cavitation. Comparisons between the dual-pulse technique and conventional photoacoustics as well as thermal photoacoustics are also presented. These investigations are supported by experimental results and will give a practical reference and guide for further developments of the technique.

[1]  S. Jacques.  Optical properties of biological tissues: a review , 2013, Physics in medicine and biology.

[2]  Martin Frenz,et al.  Photoacoustic waves excited in liquids by fiber-transmitted laser pulses , 1998 .

[3]  Shai Ashkenazi,et al.  Photoacoustic lifetime imaging of dissolved oxygen using methylene blue. , 2010, Journal of biomedical optics.

[4]  Puxiang Lai,et al.  Photoacoustically guided wavefront shaping for enhanced optical focusing in scattering media , 2014, Nature Photonics.

[5]  Lihong V. Wang,et al.  Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain , 2003, Nature Biotechnology.

[6]  Zhixing Xie,et al.  Laser-scanning optical-resolution photoacoustic microscopy. , 2009, Optics letters.

[7]  Lihong V. Wang,et al.  Grueneisen relaxation photoacoustic microscopy. , 2014, Physical review letters.

[8]  Chao Tian,et al.  Imaging and sensing based on dual-pulse nonlinear photoacoustic contrast: a preliminary study on fatty liver , 2015, Photonics West - Biomedical Optics.

[9]  Stanislav Emelianov,et al.  Sensitivity enhanced nanothermal sensors for photoacoustic temperature mapping , 2013, Journal of biophotonics.

[10]  Frank K. Tittel,et al.  Mechanism of laser ablation for aqueous media irradiated under confined‐stress conditions , 1995 .

[11]  Lihong V. Wang,et al.  Photoacoustic imaging in biomedicine , 2006 .

[12]  Erich Reichel,et al.  Study of different ablation models by use of high-speed-sampling photography , 1992, Photonics West - Lasers and Applications in Science and Engineering.

[13]  Steven L. Jacques,et al.  Laser-flash photography of laser-induced spallation in liquid media , 1992, Photonics West - Lasers and Applications in Science and Engineering.

[14]  Stanislav Emelianov,et al.  Intravascular Photoacoustics for Image-Guidance and Temperature Monitoring During Plasmonic Photothermal Therapy of Atherosclerotic Plaques: A Feasibility Study , 2013, Theranostics.

[15]  G. Paltauf,et al.  Microcavity dynamics during laser-induced spallation of liquids and gels , 1996 .

[16]  Vladimir P Zharov,et al.  Photothermal nanotherapeutics and nanodiagnostics for selective killing of bacteria targeted with gold nanoparticles. , 2006, Biophysical journal.

[17]  Pai-Chi Li,et al.  Photoacoustic temperature measurements for monitoring of thermal therapy , 2009, BiOS.

[18]  S. Emelianov,et al.  Photoacoustic imaging and temperature measurement for photothermal cancer therapy. , 2008, Journal of biomedical optics.

[19]  Lihong V. Wang.  Multiscale photoacoustic microscopy and computed tomography. , 2009, Nature photonics.

[20]  Junjie Yao,et al.  Absolute photoacoustic thermometry in deep tissue. , 2013, Optics letters.

[21]  Kirill V. Larin,et al.  Real-time optoacoustic monitoring of temperature in tissues , 2005 .

[22]  V. A. D. Grosso,et al.  Speed of Sound in Pure Water , 1972 .

[23]  Lihong V Wang,et al.  Photoacoustic tomography and sensing in biomedicine , 2009, Physics in medicine and biology.