Antioxidant Endogenous Defense in a Human Model of Physical Stress

The present work has used controlled conditions to study how physical activity and stress affect oxidant and anti-oxidant systems in a human model. Stress test consisting of one hour exercise at a cycloergometer with intensity over the 75% of the maximal cardiac frequency was followed by non-significant changes of malonyldialdehyde, assayed as a marker of lipid peroxydation, and by an increase of erythrocyte catalase and plasma and erythrocyte glutathione peroxidase after the test. These findings suggest that antioxidant response is broadly versatile and adaptable, and that physical activity may prevent extended cellular damage with consequent flogosis. Hence, controlled physical exercise may contribute to protect target organs, including cardiovascular systems, against oxidative stress.

[1]  D. Tomassoni,et al.  Leucocyte Subset Redistribution in a Human Model of Physical Stress , 2008, Clinical and experimental hypertension.

[2]  M. Freeman,et al.  Psychological Stress Compromises CD8+ T Cell Control of Latent Herpes Simplex Virus Type 1 Infections1 , 2007, The Journal of Immunology.

[3]  R. Arora,et al.  Cardiovascular manifestations of posttraumatic stress disorder. , 2007, Journal of the National Medical Association.

[4]  H. Çelik,et al.  Increased lymphocyte deoxyribonucleic acid damage in patients with cardiac syndrome X. , 2007, Mutation research.

[5]  G. Biolo,et al.  Relation between the plasma levels of LDL-cholesterol and the expression of the early marker of inflammation long pentraxin PTX3 and the stress response gene p66(ShcA) in pacemaker-implanted patients , 2007, Clinical and Experimental Medicine.

[6]  A. Sureda,et al.  Relation between oxidative stress markers and antioxidant endogenous defences during exhaustive exercise , 2005, Free radical research.

[7]  G. Fernandes.  Immunological stress in rats induces bodily alterations in saline-treated conspecifics , 2000, Physiology & Behavior.

[8]  M. Fleshner.  Exercise and Neuroendocrine Regulation of Antibody Production: Protective Effect of Physical Activity on Stress-InducedSuppression of the Specific Antibody Response , 2000, International journal of sports medicine.

[9]  S. Powers,et al.  Exercise training-induced alterations in skeletal muscle antioxidant capacity: a brief review. , 1999, Medicine and science in sports and exercise.

[10]  C. Sen,et al.  Physical Exercise and Antioxidant Defenses in the Heart a , 1999, Annals of the New York Academy of Sciences.

[11]  A. Donnelly,et al.  Elevated serum antioxidant capacity and plasma malondialdehyde concentration in response to a simulated half-marathon run. , 1998, Medicine and science in sports and exercise.

[12]  J. Davis,et al.  Effects of mode and carbohydrate on the granulocyte and monocyte response to intensive, prolonged exercise. , 1998, Journal of applied physiology.

[13]  D. Baldwin,et al.  The Effects of Voluntary Exercise and Immobilization on Humoral Immunity and Endocrine Responses in Rats , 1997, Physiology & Behavior.

[14]  S. Nakaji,et al.  Capacity of circulating neutrophils to produce reactive oxygen species after exhaustive exercise. , 1996, Journal of applied physiology.

[15]  C. Leeuwenburgh,et al.  Alteration of glutathione and antioxidant status with exercise in unfed and refed rats. , 1996, The Journal of nutrition.

[16]  D. Pyne,et al.  Moderate exercise triggers both priming and activation of neutrophil subpopulations. , 1996, The American journal of physiology.

[17]  D. Baldwin,et al.  Impact of differential housing on humoral immunity following exposure to an acute stressor in rats , 1995, Physiology & Behavior.

[18]  L. Ji.  Exercise and Oxidative Stress: Role of the Cellular Antioxidant Systems , 1995, Exercise and sport sciences reviews.

[19]  L Hoffman-Goetz,et al.  Exercise and the immune system: a model of the stress response? , 1994, Immunology today.

[20]  I. Young,et al.  Measurement of Malondialdehyde in Plasma by High Performance Liquid Chromatography with Fluorimetric Detection , 1991, Annals of clinical biochemistry.

[21]  D. Keast,et al.  Exercise and the Immune Response , 1988, Sports medicine.

[22]  B. Halliwell,et al.  Free radicals in biology and medicine , 1985 .

[23]  D. Costill,et al.  Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. , 1974, Journal of applied physiology.

[24]  H. Selye.  A Syndrome produced by Diverse Nocuous Agents , 1936, Nature.

[25]  G. Page,et al.  Named Series: Twenty years of Brain, Behavior, and Immunity Stress, NK cells, and cancer: Still a promissory note , 2007 .

[26]  M. Gleeson,et al.  The T cell and NK cell immune response to exercise. , 2005, Annals of transplantation.

[27]  M. Maynar,et al.  Stimulation of the phagocytic function of neutrophils in sedentary men after acute moderate exercise , 2004, European Journal of Applied Physiology and Occupational Physiology.

[28]  R. Shephard,et al.  Physical exercise as a human model of limited inflammatory response. , 1998, Canadian journal of physiology and pharmacology.

[29]  A. Baum,et al.  Stress and genetic testing for disease risk. , 1997, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[30]  K. Madden,et al.  Experimental basis for neural-immune interactions. , 1995, Physiological reviews.

[31]  P. Clarkson,et al.  Antioxidants and physical performance. , 1995, Critical reviews in food science and nutrition.

[32]  D. Janero,et al.  Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. , 1990, Free radical biology & medicine.