Beyond intravascular imaging: quantitative ultrasonic tissue characterization of vascular pathology

The ultimate goal of this work is to relate intravascular ultrasound imaging to quantitative ultrasonic tissue characterization. Vascular disease is responsible for the majority of deaths in the United States from coronary artery and peripheral vascular disease, stroke, and arterial dissection or rupture. The ultimate biological behavior of atherosclerotic lesions depends not only on their extent of luminal narrowing but also on their biophysical composition and material. Properties. Ultrasonic tissue characterization methods may be useful for quantitative delineation of the biophysical composition and organization of normal and pathological vascular tissue. Expansion of the diagnostic capabilities of intravascular imaging to enable quantitative tissue characterization will facilitate its widespread clinical application

[1]  R D Kamm,et al.  Effects of fibrous cap thickness on peak circumferential stress in model atherosclerotic vessels. , 1992, Circulation research.

[2]  C T Lancée,et al.  Arterial wall characteristics determined by intravascular ultrasound imaging: an in vitro study. , 1989, Journal of the American College of Cardiology.

[3]  S. Glagov,et al.  Transmural Organization of the Arterial Media: The Lamellar Unit Revisited , 1985, Arteriosclerosis.

[4]  N Bom,et al.  Intra-arterial ultrasonic imaging for recanalization by spark erosion. , 1988, Ultrasound in medicine & biology.

[5]  J W Hunt,et al.  In vitro high resolution intravascular imaging in muscular and elastic arteries. , 1992, Journal of the American College of Cardiology.

[6]  G. V. R. Born,et al.  INFLUENCE OF PLAQUE CONFIGURATION AND STRESS DISTRIBUTION ON FISSURING OF CORONARY ATHEROSCLEROTIC PLAQUES , 1989, The Lancet.

[7]  A. Daugherty,et al.  Quantitative ultrasonic characterization of lesion composition and remodeling in atherosclerotic rabbit aorta. , 1993, Arteriosclerosis and thrombosis : a journal of vascular biology.

[8]  L Landini,et al.  Time domain echo pattern evaluations from normal and atherosclerotic arterial walls: a study in vitro. , 1988, Circulation.

[9]  J. G. Miller,et al.  Quantitative ultrasonic characterization of the nature of atherosclerotic plaques in human aorta. , 1987, Circulation research.

[10]  Frederick J. Schoen,et al.  Prediction of mechanical properties of human atherosclerotic tissue by high-frequency intravascular ultrasound imaging. An in vitro study. , 1992 .

[11]  Luigi Landini,et al.  Different degrees of atherosclerosis detected by backscattered ultrasound: An in vitro study on fixed human aortic walls , 1983, Journal of clinical ultrasound : JCU.

[12]  M J Davies,et al.  Plaque fissuring--the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina. , 1985, British heart journal.

[13]  W Rutsch,et al.  A comparison of balloon-expandable-stent implantation with balloon angioplasty in patients with coronary artery disease. Benestent Study Group. , 1994, The New England journal of medicine.

[14]  J. Hodgson,et al.  Evidence that selective endothelial dysfunction may occur in the absence of angiographic or ultrasound atherosclerosis in patients with risk factors for atherosclerosis. , 1994, Journal of the American College of Cardiology.

[15]  A J Tajik,et al.  Intravascular ultrasound imaging: in vitro validation and pathologic correlation. , 1990, Journal of the American College of Cardiology.

[16]  J. G. Miller,et al.  Identification of human myocardial infarction in vitro based on the frequency dependence of ultrasonic backscatter. , 1992, The Journal of the Acoustical Society of America.

[17]  J. Griffith,et al.  Intravascular ultrasound cross-sectional arterial imaging before and after balloon angioplasty in vitro. , 1989, Circulation.

[18]  M. Leon,et al.  Impact of preintervention intravascular ultrasound imaging on transcatheter treatment strategies in coronary artery disease. , 1994, The American journal of cardiology.

[19]  P. Fitzgerald,et al.  Intravascular ultrasound imaging of blood: the effect of hematocrit and flow on backscatter. , 1992, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[20]  Fausto J. Pinto,et al.  Intravascular ultrasound imaging of coronary arteries. Is three layers the norm , 1991 .

[21]  F J Schoen,et al.  Prediction of mechanical properties of human atherosclerotic tissue by high-frequency intravascular ultrasound imaging. An in vitro study. , 1992, Arteriosclerosis and thrombosis : a journal of vascular biology.

[22]  J W Hunt,et al.  Measurement of the ultrasonic properties of vascular tissues and blood from 35-65 MHz. , 1991, Ultrasound in medicine & biology.

[23]  J. Saffitz,et al.  Quantification of intimal and medial thickness of human coronary arteries by acoustic microscopy , 1990 .

[24]  D. M. Abouelnasr,et al.  Resolution limitations in intravascular ultrasound imaging. , 1993, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[25]  P. Fitzgerald,et al.  Assessment of coronary conductance and resistance vessel reactivity in response to nitroglycerin, ergonovine and adenosine: in vivo studies with simultaneous intravascular two-dimensional and Doppler ultrasound. , 1993, Journal of the American College of Cardiology.

[26]  J. G. Miller,et al.  Quantification of atherosclerotic plaque composition in cholesterol-fed rabbits with 50-MHz acoustic microscopy. , 1992, Arteriosclerosis and thrombosis : a journal of vascular biology.

[27]  R. Kerber,et al.  Coronary arterial remodeling studied by high-frequency epicardial echocardiography: an early compensatory mechanism in patients with obstructive coronary atherosclerosis. , 1991, Journal of the American College of Cardiology.

[28]  D. M. Abouelnasr,et al.  Resolution limitations in intravascular ultrasound imaging , 1991, IEEE 1991 Ultrasonics Symposium,.

[29]  N G Pandian,et al.  Ultrasound angioscopy: real-time, two-dimensional, intraluminal ultrasound imaging of blood vessels. , 1988, The American journal of cardiology.

[30]  P. Fitzgerald,et al.  Mechanisms and outcomes of angioplasty and atherectomy assessed by intravascular ultrasound imaging , 1993, Journal of clinical ultrasound : JCU.