1 DIRECT PEPTIDE INTERACTION WITH SURFACE GLYCOSAMINOGLYCANS CONTRIBUTE TO THE CELL PENETRATION OF MAUROCALCINE

DIRECT PEPTIDE INTERACTION WITH SURFACE GLYCOSAMINOGLYCANS CONTRIBUTE TO THE CELL PENETRATION OF MAUROCALCINE Narendra Ram, Sonia Aroui, Emilie Jaumain, Hicham Bichraoui, Rémy Sadoul, Kamel Mabrouk, Michel Ronjat, Hugues Lortat-Jacob & Michel De Waard INSERM U836, Grenoble Institute of Neurosciences, Research group 3, Calcium Channels, Functions and Pathologies laboratory, 38042 Grenoble Cedex 9, Université Joseph Fourier, France, INSERM U836, Grenoble Institute of Neurosciences, Research group 2, Neurodégénérescence et Plasticité, 38042 Grenoble Cedex 9, Université Joseph Fourier, France , Université Aix-Marseille 1, 2 & 3, CNRS-UMR 6517, Chimie, Biologie et Radicaux Libres, 15521 Avenue Esc. Normandie Niemen, 13397 Marseille Cedex 20, France, Institut de Biologie Structurale, UMR 5075 CEA/CNRS/Université Joseph Fourier, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France. Running head: Maurocalcine interacts with glycosaminoglycans. Address correspondence to: Dr. Michel De Waard, Tel.: (33) 4 56 52 05 63, E-mail: michel.dewaard@ujf-grenoble.fr