Colorimetric logic gates for small molecules using split/integrated aptamers and unmodified gold nanoparticles.

Herein we report the "OR" and "AND" colorimetric logic gates for small molecules using split/integrated aptamers and unmodified gold nanoparticles, which generate visually observed outputs according to Boolean operations.

[1]  Dmitry M Kolpashchikov,et al.  Molecular logic gates connected through DNA four-way junctions. , 2010, Angewandte Chemie.

[2]  J. Szostak,et al.  In vitro selection of RNA molecules that bind specific ligands , 1990, Nature.

[3]  I. Willner,et al.  Logic gates and antisense DNA devices operating on a translator nucleic Acid scaffold. , 2009, ACS nano.

[4]  Genxi Li,et al.  Strategy to fabricate an electrochemical aptasensor: application to the assay of adenosine deaminase activity. , 2010, Analytical chemistry.

[5]  Chad A. Mirkin,et al.  One-Pot Colorimetric Differentiation of Polynucleotides with Single Base Imperfections Using Gold Nanoparticle Probes , 1998 .

[6]  Brian M. Frezza,et al.  Modular multi-level circuits from immobilized DNA-based logic gates. , 2007, Journal of the American Chemical Society.

[7]  Itamar Willner,et al.  Optical analysis of Hg2+ ions by oligonucleotide-gold-nanoparticle hybrids and DNA-based machines. , 2008, Angewandte Chemie.

[8]  Nicolas H Voelcker,et al.  Sequence-addressable DNA logic. , 2008, Small.

[9]  Tao Li,et al.  Potassium-lead-switched G-quadruplexes: a new class of DNA logic gates. , 2009, Journal of the American Chemical Society.

[10]  Milan N Stojanovic,et al.  Fluorescent Sensors Based on Aptamer Self-Assembly. , 2000, Journal of the American Chemical Society.

[11]  I. Willner,et al.  Multiplexed analysis of Hg2+ and Ag+ ions by nucleic acid functionalized CdSe/ZnS quantum dots and their use for logic gate operations. , 2009, Angewandte Chemie.

[12]  J. Macdonald,et al.  Deoxyribozyme-based ligase logic gates and their initial circuits. , 2005, Journal of the American Chemical Society.

[13]  Chunhai Fan,et al.  Adenosine detection by using gold nanoparticles and designed aptamer sequences. , 2009, The Analyst.

[14]  Darko Stefanovic,et al.  Deoxyribozyme-based logic gates. , 2002, Journal of the American Chemical Society.

[15]  L. Gold,et al.  Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. , 1990, Science.

[16]  Sai Bi,et al.  Colorimetric logic gates based on supramolecular DNAzyme structures. , 2010, Angewandte Chemie.

[17]  Chunli Bai,et al.  Signaling aptamer/protein binding by a molecular light switch complex. , 2004, Analytical chemistry.

[18]  Yan Du,et al.  Multifunctional label-free electrochemical biosensor based on an integrated aptamer. , 2008, Analytical chemistry.

[19]  Kazuo Tanaka,et al.  DNA logic gates. , 2004, Journal of the American Chemical Society.

[20]  Yi Lu,et al.  Label‐Free Colorimetric Detection of Lead Ions with a Nanomolar Detection Limit and Tunable Dynamic Range by using Gold Nanoparticles and DNAzyme , 2008 .

[21]  Byoung-Tak Zhang,et al.  The use of gold nanoparticle aggregation for DNA computing and logic-based biomolecular detection , 2008, Nanotechnology.

[22]  Kevin W Plaxco,et al.  High specificity, electrochemical sandwich assays based on single aptamer sequences and suitable for the direct detection of small-molecule targets in blood and other complex matrices. , 2009, Journal of the American Chemical Society.

[23]  G. Seelig,et al.  Enzyme-Free Nucleic Acid Logic Circuits , 2022 .

[24]  E. Wang,et al.  Simple and sensitive aptamer-based colorimetric sensing of protein using unmodified gold nanoparticle probes. , 2007, Chemical communications.

[25]  Wataru Yoshida,et al.  Photonic Boolean logic gates based on DNA aptamers. , 2007, Chemical communications.

[26]  N. Sugimoto,et al.  DNA logic gates based on structural polymorphism of telomere DNA molecules responding to chemical input signals. , 2006, Angewandte Chemie.

[27]  Yi Lu,et al.  Adenosine-dependent assembly of aptazyme-functionalized gold nanoparticles and its application as a colorimetric biosensor. , 2004, Analytical chemistry.

[28]  Yan Du,et al.  Aptamer-controlled biofuel cells in logic systems and used as self-powered and intelligent logic aptasensors. , 2010, Journal of the American Chemical Society.

[29]  Atsushi Ogawa,et al.  Easy design of logic gates based on aptazymes and noncrosslinking gold nanoparticle aggregation. , 2009, Chemical communications.

[30]  A. Saghatelian,et al.  DNA-based photonic logic gates: AND, NAND, and INHIBIT. , 2003, Journal of the American Chemical Society.

[31]  Xiaofang Hu,et al.  Unmodified gold nanoparticles as a colorimetric probe for potassium DNA aptamers. , 2006, Chemical communications.

[32]  J. Storhoff,et al.  Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanoparticles. , 1997, Science.

[33]  X. Liu,et al.  A Gold Nanoparticle‐Based Aptamer Target Binding Readout for ATP Assay , 2007 .

[34]  Yi Lu,et al.  A colorimetric lead biosensor using DNAzyme-directed assembly of gold nanoparticles. , 2003, Journal of the American Chemical Society.

[35]  Yingfu Li,et al.  Structure-switching signaling aptamers. , 2003, Journal of the American Chemical Society.

[36]  Genxi Li,et al.  Regulation of Thrombin Activity with a Bifunctional Aptamer and Hemin: Development of a New Anticoagulant and Antidote Pair , 2009, Chembiochem : a European journal of chemical biology.

[37]  Chunhai Fan,et al.  Visual cocaine detection with gold nanoparticles and rationally engineered aptamer structures. , 2008, Small.

[38]  Milan N Stojanovic,et al.  Aptamer-based colorimetric probe for cocaine. , 2002, Journal of the American Chemical Society.

[39]  Yi Lu,et al.  Smart Nanomaterials Responsive to Multiple Chemical Stimuli with Controllable Cooperativity , 2006 .

[40]  Yingfu Li,et al.  DNA aptamer folding on gold nanoparticles: from colloid chemistry to biosensors. , 2008, Journal of the American Chemical Society.

[41]  Kui Jiao,et al.  Colorimetric detection of mercury ion (Hg2+) based on DNA oligonucleotides and unmodified gold nanoparticles sensing system with a tunable detection range. , 2009, Biosensors & bioelectronics.

[42]  Huixiang Li,et al.  Label-free colorimetric detection of specific sequences in genomic DNA amplified by the polymerase chain reaction. , 2004, Journal of the American Chemical Society.

[43]  Juewen Liu,et al.  Fast colorimetric sensing of adenosine and cocaine based on a general sensor design involving aptamers and nanoparticles. , 2005, Angewandte Chemie.

[44]  Guo-Li Shen,et al.  Highly sensitive and selective bifunctional oligonucleotide probe for homogeneous parallel fluorescence detection of protein and nucleotide sequence. , 2011, Analytical chemistry.

[45]  Itamar Willner,et al.  Sensing of UO22+ and design of logic gates by the application of supramolecular constructs of ion-dependent DNAzymes. , 2009, Nano letters.

[46]  Chunhai Fan,et al.  Design of a gold nanoprobe for rapid and portable mercury detection with the naked eye. , 2008, Chemical communications.

[47]  Ming Zhou,et al.  Microfluidic electrochemical aptameric assay integrated on-chip: a potentially convenient sensing platform for the amplified and multiplex analysis of small molecules. , 2011, Analytical chemistry.

[48]  Huixiang Li,et al.  Colorimetric detection of DNA sequences based on electrostatic interactions with unmodified gold nanoparticles. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[49]  Chunhai Fan,et al.  Target-responsive structural switching for nucleic acid-based sensors. , 2010, Accounts of chemical research.

[50]  Yi Xiao,et al.  Label-free, dual-analyte electrochemical biosensors: a new class of molecular-electronic logic gates. , 2010, Journal of the American Chemical Society.

[51]  Chunhai Fan,et al.  Construction of molecular logic gates with a DNA-cleaving deoxyribozyme. , 2006, Angewandte Chemie.

[52]  Chad A Mirkin,et al.  Colorimetric detection of mercuric ion (Hg2+) in aqueous media using DNA-functionalized gold nanoparticles. , 2007, Angewandte Chemie.

[53]  Itamar Willner,et al.  Parallel Analysis of Two Analytes in Solutions or on Surfaces by Using a Bifunctional Aptamer: Applications for Biosensing and Logic Gate Operations , 2008, Chembiochem : a European journal of chemical biology.