Adverse drug reactions in Germany: direct costs of internal medicine hospitalizations

German hospital reimbursement modalities changed as a result of the introduction of Diagnosis Related Groups (DRG) in 2004. Therefore, no data on the direct costs of adverse drug reactions (ADRs) resulting in admissions to departments of internal medicine are available. The objective was to quantify the ADR‐related economic burden (direct costs) of hospitalizations in internal medicine wards in Germany.

[1]  H. Beijer,et al.  Hospitalisations caused by adverse drug reactions (ADR): a meta-analysis of observational studies , 2002, Pharmacy World and Science.

[2]  J. Stausberg.  Die Kodierqualität in der stationären Versorgung , 2007, Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz.

[3]  J. Stausberg.  [Quality of coding in acute inpatient care]. , 2007, Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz.

[4]  T. Buclin,et al.  Rate, type, and cost of adverse drug reactions in emergency department admissions. , 2001, European journal of internal medicine.

[5]  L. Härmark,et al.  Pharmacovigilance: methods, recent developments and future perspectives , 2008, European Journal of Clinical Pharmacology.

[6]  P. Noyce,et al.  Hospital Admissions Associated with Adverse Drug Reactions: A Systematic Review of Prospective Observational Studies , 2008, The Annals of pharmacotherapy.

[7]  N. Moore,et al.  Frequency and cost of serious adverse drug reactions in a department of general medicine. , 1998, British journal of clinical pharmacology.

[8]  G. Schumock,et al.  Focusing on the preventability of adverse drug reactions. , 1992, Hospital pharmacy.

[9]  C. Marone,et al.  [Adverse internal medicine drug effects at hospital admission]. , 1999, Schweizerische medizinische Wochenschrift.

[10]  F. Haramburu,et al.  [Medical and socio-economical impact of drug-induced adverse reactions]. , 2005, Presse medicale.

[11]  R. Rodriguez-Monguio,et al.  Assessing the Economic Impact of Adverse Drug Effects , 2012, PharmacoEconomics.

[12]  M. Pirmohamed,et al.  Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients , 2004, BMJ : British Medical Journal.

[13]  M. Deutsch,et al.  Adverse drug reactions as a cause of hospital admissions: a 6-month experience in a single center in Greece. , 2008, European journal of internal medicine.

[14]  Tom Stargardt,et al.  Methods to determine reimbursement rates for diagnosis related groups (DRG): A comparison of nine European countries , 2006, Health care management science.

[15]  I. Edwards,et al.  Adverse drug reactions: definitions, diagnosis, and management , 2000, The Lancet.

[16]  P. Schneider,et al.  Preventability and severity assessment in reporting adverse drug reactions. , 1992, American journal of hospital pharmacy.

[17]  D. Schreiber,et al.  Drug-Related Emergency Department Visits in an Elderly Veteran Population , 2005, The Annals of pharmacotherapy.

[18]  L. Boothby,et al.  Analysis of adverse drug reactions for preventability , 2007, International journal of clinical practice.

[19]  Sebastian Schneeweiss,et al.  Admissions caused by adverse drug events to internal medicine and emergency departments in hospitals: a longitudinal population-based study , 2002, European Journal of Clinical Pharmacology.

[20]  J Hasford,et al.  Adverse drug reaction monitoring—cost and benefit considerations. Part II: cost and preventability of adverse drug reactions leading to hospital admission , 1997, Pharmacoepidemiology and drug safety.

[21]  Z. T. Grapes,et al.  Factors associated with preventable adverse drug reactions. , 1994, American journal of hospital pharmacy.

[22]  Sophie Gautier,et al.  The cost of adverse drug reactions , 2003, Expert opinion on pharmacotherapy.

[23]  Conséquences médicales et socio-économiques des effets indésirables médicamenteux , 2005 .

[24]  R R Miller,et al.  Detection and evaluation of adverse drug reactions. , 1972, JAMA.

[25]  Kay Brune,et al.  Lack of Awareness of Community-Acquired Adverse Drug Reactions Upon Hospital Admission , 2003, Drug safety.

[26]  Jonas Schreyögg,et al.  Cost accounting to determine prices: How well do prices reflect costs in the German DRG-system? , 2006, Health care management science.

[27]  N. Moore,et al.  Adverse drug reactions in a department of systemic diseases-oriented internal medicine: prevalence, incidence, direct costs and avoidability , 2000, European Journal of Clinical Pharmacology.

[28]  B J O'Brien,et al.  Analysis of uncertainty in health care cost-effectiveness studies: an introduction to statistical issues and methods , 2002, Statistical methods in medical research.

[29]  J Jouglard,et al.  [Imputation of the unexpected or toxic effects of drugs. Actualization of the method used in France]. , 1985, Therapie.