Retinal Vessel Segmentation in Fundoscopic Images with Generative Adversarial Networks

Retinal vessel segmentation is an indispensable step for automatic detection of retinal diseases with fundoscopic images. Though many approaches have been proposed, existing methods tend to miss fine vessels or allow false positives at terminal branches. Let alone under-segmentation, over-segmentation is also problematic when quantitative studies need to measure the precise width of vessels. In this paper, we present a method that generates the precise map of retinal vessels using generative adversarial training. Our methods achieve dice coefficient of 0.829 on DRIVE dataset and 0.834 on STARE dataset which is the state-of-the-art performance on both datasets.

[1]  Alexei A. Efros,et al.  Image-to-Image Translation with Conditional Adversarial Networks , 2016, 2017 IEEE Conference on Computer Vision and Pattern Recognition (CVPR).

[2]  Soumith Chintala,et al.  Unsupervised Representation Learning with Deep Convolutional Generative Adversarial Networks , 2015, ICLR.

[3]  Victor S. Lempitsky,et al.  N4-Fields: Neural Network Nearest Neighbor Fields for Image Transforms , 2014, ArXiv.

[4]  Sven Loncaric,et al.  Retinal Vessel Segmentation using Deep Neural Networks , 2015, VISAPP.

[5]  Roberto Marcondes Cesar Junior,et al.  Retinal vessel segmentation using the 2-D Gabor wavelet and supervised classification , 2005, IEEE Transactions on Medical Imaging.

[6]  Yoshua Bengio,et al.  Generative Adversarial Nets , 2014, NIPS.

[7]  Luc Van Gool,et al.  Deep Retinal Image Understanding , 2016, MICCAI.

[8]  Elisa Ricci,et al.  Retinal Blood Vessel Segmentation Using Line Operators and Support Vector Classification , 2007, IEEE Transactions on Medical Imaging.

[9]  Simon Osindero,et al.  Conditional Generative Adversarial Nets , 2014, ArXiv.

[10]  Kotagiri Ramamohanarao,et al.  An effective retinal blood vessel segmentation method using multi-scale line detection , 2013, Pattern Recognit..

[11]  Lei Zhang,et al.  Retinal vessel extraction by matched filter with first-order derivative of Gaussian , 2010, Comput. Biol. Medicine.

[12]  Jian Sun,et al.  Deep Residual Learning for Image Recognition , 2015, 2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR).

[13]  Stephen Lin,et al.  DeepVessel: Retinal Vessel Segmentation via Deep Learning and Conditional Random Field , 2016, MICCAI.

[14]  Thomas Brox,et al.  U-Net: Convolutional Networks for Biomedical Image Segmentation , 2015, MICCAI.

[15]  N. Otsu A threshold selection method from gray level histograms , 1979 .

[16]  Vincent Lepetit,et al.  Supervised Feature Learning for Curvilinear Structure Segmentation , 2013, MICCAI.